A5102002312- Catalysis for Biomass Conversion
- Osteoarthritis Treatment and Mechanisms
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Telomeres, Telomerase, and Senescence
- Birth, Development, and Health
- Mesoporous Materials and Catalysis
- Biofuel production and bioconversion
- Cytokine Signaling Pathways and Interactions
- Supercapacitor Materials and Fabrication
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- Hematopoietic Stem Cell Transplantation
- Periodontal Regeneration and Treatments
- Cardiovascular Issues in Pregnancy
- Protease and Inhibitor Mechanisms
- interferon and immune responses
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Advanced Computational Techniques and Applications
- Advanced Cellulose Research Studies
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Southern Medical University
2015-2025
Guangdong Academy of Medical Sciences
2025
Guangdong Provincial People's Hospital
2025
Jimei University
2023-2024
First Affiliated Hospital of Zhengzhou University
2024
Nanfang Hospital
2015-2023
Anhui Provincial Center for Disease Control and Prevention
2022-2023
Lanzhou University
2021-2022
Lanzhou University Second Hospital
2021-2022
Shanghai University of Traditional Chinese Medicine
2022
Whether sensory nerve can sense bone density or metabolic activity to control homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in nerves regulate formation inhibiting sympathetic through the central nervous system. osteoblasts increases when decreases as demonstrated osteoporotic animal models. Ablation of erodes skeletal integrity. Specifically, knockout EP4 gene cyclooxygenase-2 (COX2) significantly reduces volume...
The periosteum, a thin tissue that covers almost the entire bone surface, accounts for more than 80% of human mass and is essential regeneration. Its osteogenic regenerative abilities are well studied, but much unknown about periosteum. In this study, we found macrophage-lineage cells recruit periosteum-derived (PDCs) cortical formation. Knockout colony stimulating factor-1 eliminated resulted in loss PDCs with impaired periosteal Moreover, TRAP+ induced transcriptional expression periostin...
Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory and autoimmune conditions in children, have adverse effects on growing skeleton. GCs inhibit angiogenesis bone, but underlying mechanisms remain unclear. Here, we show that GC treatment young mice induces vascular endothelial cell senescence metaphysis long inhibition improves GC-impaired bone with coupled osteogenesis. We identify angiogenin (ANG), a ribonuclease pro-angiogenic activity, secreted...
Mesenchymal stem/progenitor cells (MSPCs) undergo rapid self-renewal and differentiation, contributing to fast skeletal growth during childhood puberty. It remains unclear whether these change their properties late puberty young adulthood, when bone accrual decelerate. Here we show that MSPCs in primary spongiosa of long mice at normal programmed senescence, characterized by loss nestin expression. MSPC senescence is epigenetically controlled the polycomb histone methyltransferase enhancer...
Mesenchymal stem cells (MSCs) participate in the repair/remodelling of many tissues, where MSCs commit to different lineages dependent on cues local microenvironment. Here we show that TGFβ-activated RhoA/ROCK signalling functions as a molecular switch regarding fate arterial after injury. differentiate into myofibroblasts when is turned on, endothelial off. The former pathophysiologic resulting intimal hyperplasia, whereas latter physiological leading repair. Further analysis revealed MSC...
Low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor for Wnt signaling and can be recruited by multiple growth factors/hormones to their receptors facilitating intracellular activation. The ligands that bind directly LRP6 have not been identified. Here, we report bioactive oxidized phospholipids (oxPLs) are native of LRP6, but the closely related LRP5. oxPLs products lipid oxidation involving in pathological conditions such as hyperlipidemia, atherosclerosis,...
Abnormal bone formation in subchondral resulting from uncoupled remodeling is considered a central feature osteoarthritis (OA) pathogenesis. H-type vessels can couple angiogenesis and osteogenesis. We previously revealed that elevated were correlated with OA focal adhesion kinase (FAK) MSCs critical for vessel osteoporosis. The aim of this study was to explore the correlation between pathogenesis through regulation using defactinib (an FAK inhibitor).In vivo: 3-month-old male C57BL/6J (WT)...
In the mammalian skeletal system, osteogenesis and angiogenesis are closely linked by type H vessels during bone regeneration repair. Our previous studies confirmed promotion of these processes copper-containing metal (CCM) in vitro vivo . However, whether how coupling participates CCM is unknown. this study, M2a macrophages but not M2c were shown to be immunoregulated CCM. A CCM, 316L−5Cu, was applied drilling hole injuries tibia C57/6 mice for comparison. We observed advanced formation...
To explore the association between perioperative SARS-CoV-2 infection and postoperative complications during breakout of Omicron epidemic wave. Observational retrospective cohort study. Multivariable logistic regression was performed to duration from surgery COVID-19 diagnosis likelihood complications. A general hospital in China. 7927 patients aged 18 years older who underwent surgical treatment 1 December 2022 28 February 2023. The outcome a composite adverse events that occurred within...
Current research suggests that chronic high-fat dietary intake can lead to bone loss in adults; however, the mechanism by which diets affect development of osteoporosis individuals is unclear. As are strongly associated with ferroptosis, whether ferroptosis mediates diet-induced was focus our current study. By dividing mice into a diet group, + inhibitor group and normal chow were given for 12 weeks. The 1 mg/kg Fer-1 per day intraperitoneally at start diet. Microscopic CT scans,...
Background: As an effective antitumor drug, doxorubicin (DOX) is primarily used to treat solid tumors and hematologic malignancies. However, increasing evidence has emerged indicating its cardiotoxicity, few solutions have been proposed counter this side effect. Higenamine (HG) a natural compound widely found in many Chinese herbs also serves as component healthcare products. Several studies demonstrated cardioprotective effect different models, but little known about the underlying...
Feminized 2-year-old eels were reared in freshwater at 26℃ until October, then the water temperature was gradually decreased to 16℃ December, and increased from February April. They received weekly injections of salmon pituitary extract (body weight, 15 or 30 mg/kg) induce sexual maturation September, The quality eggs obtained each season evaluated by resulting fertilization, hatching, 8-day sur- vival rates. High via high-dose most experimental groups. In injection groups, induced final...
Abstract Osteoarthritis (OA), a disease of the entire joint, is characterized by abnormal bone remodeling and coalescent degradation articular cartilage. We have previously found that elevated levels H‐type vessels in subchondral correlate with OA focal adhesion kinase (FAK) critical for vessel formation osteoporosis. However, potential role FAK remains unexplored. Here, we demonstrate p‐FAK level was dramatically following anterior cruciate ligament transection (ACLT) rats. Specific...
Senolytics are a class of drugs that selectively eliminate senescent cells and ameliorate senescence-associated disease. Studies have demonstrated the accumulation disc production secretory phenotype decrease number functional in degenerative tissue. It has been determined clearance cell by senolytics rejuvenates various types several human organs, including largest avascular structure, intervertebral (IVD). The microvasculature marrow space bony endplate (BEP) structural foundation nutrient...
Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak mass in adult offspring. Here we evaluated whether how PDE affects postnatal long growth mouse Pregnant mice were injected subcutaneously (1.2 mg/kg/day) every morning from gestational days (GD) 12-14. Femurs tibias 2-, 4-, 6-, 12-week-old female offspring harvested for histological, immunofluorescence, flow cytometric analysis, or microcomputed...
The occurrence of type 2 diabetes(T2D) increases with age. platelet-derived growth factor (PDGF) is one the key factors regulating β cell proliferation and function, but contribution PDGF signaling in cells aging senescence remains unexplored. Here, we showed that level both serum tissue PDGF-AA decreased age, was positively correlated function aging. decline partly due to number as well secretion osteoblast lineage bone tissue. Conditioned medium from induced insulinoma insulin vitro, while...
Background: Substantial evidence shows that crosstalk between cartilage and subchondral bone may play an important role in repair. Animal models have shown hydroxyapatite-grafted-chitosan implant (HA-g-CS) moderate-intensity exercise promote regeneration of osteochondral defects. However, no vivo studies demonstrated these two factors a synergistic activity to facilitate remodeling mice, thus supporting bone-cartilage Questions: This study was clarify whether HA-g-CS might effect on...
In this study, hydrothermal conversion of passion fruit husk powder (PFHP) into levulinic acid (LA) was achieved using SO3H-functionalized ionic liquids (ILs) as catalyst. The investigation focused on the impact IL types and reaction conditions (temperature, time, water quantity catalyst loading) LA yield. Among selected ILs, [C4SO3Hmim][HSO4] exhibited highest yield at 66.6%, under specific conditions: 4 h 180 °C temperature, 0.2 g PFHP, 1.5 IL, 6.0 deionized water. Remarkably, displayed...