A5063947761- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Misinformation and Its Impacts
- Opinion Dynamics and Social Influence
- Knowledge Management and Sharing
- Social Media and Politics
- Open Source Software Innovations
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Phytochemistry and Biological Activities
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Flavonoids in Medical Research
- Business Strategy and Innovation
- Technology and Security Systems
- Vitamin C and Antioxidants Research
- Expert finding and Q&A systems
- Cybersecurity and Cyber Warfare Studies
- Ultrasound in Clinical Applications
Center of Hubei Cooperative Innovation for Emissions Trading System
2025
Huazhong Agricultural University
2025
Guangdong Academy of Medical Sciences
2022-2024
Southern Medical University
2013-2024
Shantou University
2024
Shantou University Medical College
2024
VA Sepulveda Ambulatory Care Center
2024
University of California, Los Angeles
2024
Guangdong Provincial People's Hospital
2022-2024
Massachusetts Institute of Technology
1996-2024
BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine encoding prefusion-stabilized, membrane-anchored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length spike protein. highly efficacious against disease 2019 (Covid-19) and currently approved, conditionally or authorized for emergency use worldwide. At the time of initial authorization, data beyond months after vaccination were unavailable.In an ongoing, placebo-controlled, observer-blinded,...
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or pseudoviruses with sera 51 participants who received two three doses messenger RNA (mRNA)-based COVID-19 vaccine BNT162b2. After doses,...
ABSTRACT Background BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine encoding prefusion-stabilized, membrane-anchored SARS-CoV-2 full-length spike protein. highly efficacious against COVID-19 and currently authorized for emergency use or conditional approval worldwide. At the time of authorization, data beyond 2 months post-vaccination were unavailable. Methods In an ongoing, placebo-controlled, observer-blinded, multinational, pivotal efficacy study, 44,165...
Abstract The newly emerged Omicron SARS-CoV-2 has several distinct sublineages including BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge is being replaced by whereas BA.3 at a low prevalence this time. Here we report neutralization of BNT162b2-vaccinated sera (collected 1 month after dose 3) against three sublineages. To facilitate testing, have engineered complete or spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All neutralize USA-WA1/2020, BA.1-, BA.2-, BA.3-spike SARS-CoV-2s...
Abstract The BNT162b2 bivalent BA.4/5 COVID-19 vaccine has been authorized to mitigate due current Omicron and potentially future variants. New sublineages of SARS-CoV-2 continue emerge have acquired additional mutations, particularly in the spike protein, that may lead improved viral fitness immune evasion. present study characterized neutralization activities against new BA.4.6, BA.2.75.2, BQ.1.1, XBB.1 after a 4 th dose (following three doses BNT162b2) either original monovalent or...
Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original variant BA.1. Here, we report neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized BA.1-infected against "Deltacron" (XD). post-dose 3 neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, XD-spike SARS-CoV-2s with geometric mean titres (GMTs) 1335, 393, 298, 315, 216, 103, 301, respectively; thus, BA.4/5 spike showed highest...
Abstract Background In the post-pandemic era, a wide range of COVID-19 sequelae is growing health concern. However, risks digestive diseases in long COVID have not been comprehensively understood. To investigate long-term risk among patients. Methods this large-scale retrospective cohort study with up to 2.6 years follow-up (median follow-up: 0.7 years), group ( n = 112,311), contemporary comparison 359,671) and historical 370,979) predated outbreak were built using UK Biobank database. Each...
The SARS-CoV-2 Omicron variant and its sublineages show pronounced viral escape from neutralizing antibodies elicited by vaccination or prior infection owing to over 30-amino acid alterations within the spike (S) glycoprotein. Breakthrough of vaccinated individuals with BA.1 BA.2 is associated distinct patterns cross-neutralizing activity against variants concern (VOCs). In continuation our previous work, we characterized effect BA.4/BA.5 S glycoprotein exposure on antibody response upon...
Ultrasonic-assisted extraction (UAE) was developed to extract phenolic and flavonoid antioxidants from Clerodendrum cyrtophyllum Turcz leaves. The optimal experimental parameters for antioxidant C. leaves were measured using single-factor experimentation combined with response surface methodology (RSM). Total content (TPC) total (TFC) assays used quantify compounds. Next, radical scavenging capacity 2,2′-diphenyl-1-picrylhydrazyl (DPPH) 2,2′ -azino-bis(3-ethylbenzothiazoline-6-sulphonicacid)...
In response to intense pressure, technology companies have enacted policies combat misinformation
Abstract Porcine epidemic diarrhea virus (PEDV) is a highly infectious intestinal coronavirus that poses significant threat to the pig industry because of its strong virulence and propensity for mutation recombination. PEDV classified into three major genotypes based on spike (S) gene sequence: G1 (classical), G2 (variant), S-INDEL (characterized by nucleotide insertions/deletions in S gene). Both have been frequently detected China, whereas strain has rarely reported or isolated. In this...
Abstract A new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage, B.1.1.529, was recently detected in Botswana and South Africa is now circulating globally. Just two days after it first reported to the World Health Organization (WHO), this strain classified as a variant of concern (VOC) named Omicron. Omicron has an unusually large number mutations, including up 39 amino acid modifications spike (S) protein, raising concerns that its recognition by neutralizing antibodies...
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association PPIs with influenza is unexplored, while that pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use increases the risks these respiratory infections. current included 160,923 eligible participants at baseline who completed questionnaires on medication use, which histamine-2 receptor antagonist (H2RA), from UK Biobank. Cox proportional hazards regression and propensity...
Abstract We report the antibody neutralization against Omicron SARS-CoV-2 after 2 and 3 doses of BNT162b2 mRNA vaccine. Vaccinated individuals were serially tested for their wild-type (strain USA-WA1/2020) an engineered USA-WA1/2020 bearing spike glycoprotein. Plaque reduction results showed that at or 4 weeks post-dose-2, geometric mean titers (GMTs) 511 20 Omicron-spike viruses, respectively, suggesting two not sufficient to elicit robust Omicron; 1 month post-dose-3, GMTs increased 1342...
Abstract Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original variant BA.1. Here we report neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized BA.1-infected against “Deltacron” (XD). post-dose 3 neutralized USA-WA1/2020, BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, XD-spike SARS-CoV-2s with geometric mean titers (GMTs) 1335, 393, 298, 315, 216, 103, 301, respectively; thus, BA.4/5 spike showed highest...
Abstract Objectives To prospectively investigate the associations of habitual fish oil use with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospital admission, or mortality Corona Virus Disease-19 (COVID-19) in a large-scale cohort. Design Prospective population-based cohort study. Setting UK Biobank. Participants A total 110 440 participants aged 37 -73 years who completed questionnaire on supplement use, which included at baseline were enrolled between 2006 and...
Abstract The newly emerged Omicron SARS-CoV-2 has 3 distinct sublineages: BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge is being replaced by whereas BA.3 at a low prevalence this time. Here we report neutralization of BNT162b2-vaccinated sera (collected 1 month after dose 3) against three sublineages. To facilitate testing, engineered complete or spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All neutralized USA-WA1/2020, BA.1-, BA.2-, BA.3-spike SARS-CoV-2s with titers...
In response to intense pressure from policy makers and the public, technology companies have enacted a range of policies aimed at reducing spread misinformation online1-3. The enforcement these has, however, led being regularly accused political bias4-6. We argue that even under politically neutral anti-misinformation policies, such asymmetries in should be expected, as there is asymmetry sharing misinformation7-12. support this argument with an analysis Twitter data 9,000 active users...
Abstract The SARS-CoV-2 Omicron variant and its sublineages show pronounced viral escape from neutralizing antibodies elicited by vaccination or prior infection owing to over 30 amino acid alterations within the spike (S) glycoprotein. We others have recently reported that breakthrough of vaccinated individuals with BA.1 BA.2 are associated distinct patterns cross-neutralizing activity against variants concern (VOCs). mediated overall stronger cross-neutralization descendants (BA.2.12.1,...