A5101660753- Bioactive Natural Diterpenoids Research
- Traditional and Medicinal Uses of Annonaceae
- Cancer-related molecular mechanisms research
- Autism Spectrum Disorder Research
- Marine Sponges and Natural Products
- Tryptophan and brain disorders
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Chemical Synthesis and Reactions
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Biological Activities
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Sulfur-Based Synthesis Techniques
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
Chongqing University
2024
Hunan Agricultural University
2024
First People's Hospital of Chongqing
2024
Guangzhou Medical University
2024
Guangzhou First People's Hospital
2024
South China University of Technology
2024
Nanjing University of Aeronautics and Astronautics
2023-2024
Wuhan Institute of Technology
2023
Huazhong University of Science and Technology
2019-2023
Southern Medical University
2014-2022
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The mechanisms underlying ASD are unclear. Astrocyte alterations noted in patients and animal models. However, whether astrocyte dysfunction causal or consequential to ASD-like phenotypes mice unresolved. Type 2 inositol 1,4,5-trisphosphate 6 receptors (IP3R2)-mediated Ca2+ release from intracellular stores results the activation of astrocytes. Mutations IP3R2 gene associated with ASD. Here, we show that both IP3R2-null...
Extracellular protein disulfide isomerase (PDI) is a promising target for thrombotic-related diseases. Four potent PDI inhibitors with unprecedented chemical architectures, piericones A–D (1–4), were isolated from Pieris japonica. Their structures elucidated by spectroscopic data analysis, methods, quantum 13C nuclear magnetic resonance DP4+ and electronic circular dichroism calculations, single-crystal X-ray diffraction analysis. Piericones A (1) B (2) nanomolar noncompetitive possessing an...
A novel triamino monoterpene indole alkaloid with an unprecedented skeleton, gelstriamine (1), four new alkaloids (2–5), and 12 known analogues (6–17) were isolated from Gelsemium elegans. The structures of 1–5 established using extensive spectroscopic techniques, NMR calculations iJ/dJ-DP4 2D C–H COSY ANNs analysis, ECD calculations, chemical methods, single crystal X-ray diffraction analysis. Gelstriamine (1) possesses 6/5/7/6/6/5 heterohexacyclic scaffold bearing a unique...
Comprehensive Summary Six highly oxygenated dimeric grayanane diterpenoids (1—6) including three new ones, bismollethers A—C (1—3), were isolated from the flowers of Rhododendron molle collected at Qichun, Hubei, China. The structures and relative configurations 1—6 determined by comprehensive spectroscopic data analysis 13 C NMR calculation with DP4+ analysis. absolute (1—3) birhodomollein B (5) indubitably assigned single‐crystal X‐ray diffraction analysis, revealing head‐to‐tail linking...
Thirteen new grayanane diterpenoids (1–13) and 15 known analogues (14–28) were isolated from a leaf extract of Pieris japonica. Their structures determined by spectrometric spectroscopic methods, including HRESIMS, NMR, IR, UV. The absolute configurations 1, 3, 7–9, 16 defined single-crystal X-ray diffraction analysis. 17-Hydroxygrayanotoxin XIX (1) represents the first example 17-hydroxygrayan-15(16)-ene diterpenoid. Diterpenoids 1–28 evaluated for their antinociceptive activities, 4, 9,...
<title>Abstract</title> NingXiang (NX) pig has been recognized as one of the most famous Chinese indigenous breeds due to its characteristics in high fertility and stress resistance. However, global intestinal gene expression profiling feature gut microorganisms NX piglets have not studied. Here, we compared microbiome transcriptome between Duroc × Landrace Large white (DLY) found enrichment several colonic <italic>Bacteroides, Prevotella</italic> <italic>Clostridium</italic> species than...
<title>Abstract</title> <bold>Background</bold> NingXiang (NX) pig has been characterized as one of the best Chinese indigenous breeds, with high fertility and disease resistance. However, its intestinal gene expression gut microbial characteristics have not studied. <bold>Results</bold> Here, we delineated compared profile microbiome transcriptome between NX Duroc × Landrace Large white (DLY) piglets by integrating metagenomic transcriptomic analyses. We found that abundance several colonic...
Oxalis xishuiensis , a new species of Oxalidaceae from Danxia landforms Xishui County, Guizhou, China, is described and illustrated. It morphologically similar to O. wulingensis by the two lateral leaflets arranged at about 180° angle oblong pink petals with lilac veins, but clearly differs latter almost as long wide, obliquely obcordate leaflets, shorter peduncles, longer capsule (1.2–1.5 cm vs. 0.5–0.7 cm) alveolate seeds.
NingXiang (NX) pig is one of Chinese indigenous breeds, with dominant characteristics in stress resistance. However, its gut microbial features and gene profiling have not been studied. Here, we compared the intestinal microbiome transcriptome between NX DLY piglets found high enrichment several colonic Bacteroides, Prevotella Clostridium species piglets. Further functional analyses revealed their predominant function methane, glycolysis gluconeogenesis metabolism. Our mRNA-sequencing data...