A5101415794- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Computational Techniques and Applications
- Photoreceptor and optogenetics research
- 3D Printing in Biomedical Research
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- AI-based Problem Solving and Planning
- Liver Disease and Transplantation
- Advanced Database Systems and Queries
- Constraint Satisfaction and Optimization
- Metal complexes synthesis and properties
- Cellular transport and secretion
- Neurobiology and Insect Physiology Research
- Pericarditis and Cardiac Tamponade
- Systemic Lupus Erythematosus Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Energy Efficiency in Computing
- Cancer and Skin Lesions
- Vascular anomalies and interventions
- Kidney Stones and Urolithiasis Treatments
- Coronary Artery Anomalies
- Biological and pharmacological studies of plants
- Cardiac Arrhythmias and Treatments
- Comparative Animal Anatomy Studies
Guangzhou First People's Hospital
2024
South China University of Technology
2024
Guangzhou Medical University
2024
Brunswick (United States)
2022
Rutgers, The State University of New Jersey
2022
Affiliated Hospital of Southwest Medical University
2021
First Affiliated Hospital Zhejiang University
2015-2020
Xi'an Jiaotong University
2004-2020
Zhejiang University
2020
Massachusetts Institute of Technology
2014-2018
Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ) is a family palmitoyl acyltransferase that implicated in palmitoylation and regulated trafficking of diverse substrates function either at inhibitory or excitatory synapses. Of particular interest the γ2 subunit GABA A receptors, which required for targeting these receptors to Here, we report GODZ and, lesser extent, its close paralog sertoli cell gene with domain-β (SERZ-β) are main members enzymes able palmitoylate...
Machine learning has begun to play a central role in many applications. A multitude of these applications typically also involve datasets that are distributed across multiple computing devices/machines due either design constraints (e.g., multi-agent and Internet-of-Things systems) or computational/privacy reasons large-scale machine on smartphone data). Such often require the tasks be carried out decentralized fashion, which there is no server directly connected all nodes. In real-world...
Clustering of inhibitory γ-aminobutyric acidA (GABAA) and glycine receptors at synapses is thought to involve key interactions between the receptors, a "scaffolding" protein known as gephyrin RhoGEF collybistin. We report identification balanced chromosomal translocation in female patient presenting with disturbed sleep-wake cycle, late-onset epileptic seizures, increased anxiety, aggressive behavior, mental retardation, but not hyperekplexia. Fine mapping breakpoint indicates disruption...
Sequential formation of GABAergic and glutamatergic synapses is thought to be crucial for constructing the stereotypic neural networks during brain development. However, why are formed earlier than in developing not well understood. We used electrophysiology fluorescence imaging study synaptogenesis embryonic hypothalamic cultures, which contain ∼40% ∼60% neurons. The newly dissociated neurons contained a significant pool functional GABA A receptors but very low level glutamate receptors....
Deficits in GABAergic inhibitory transmission are a hallmark of temporal lobe epilepsy and have been replicated animal tissue culture models epilepsy. inhibition comprises phasic tonic that is mediated by synaptic extrasynaptic GABAA receptors, respectively. We recently demonstrated chronic stimulation with cyclothiazide (CTZ) or kainic acid (KA) induces robust epileptiform activity hippocampal neurons both vitro vivo. Here, we report downregulation GABA after epileptogenic rat cultures....
To evaluate the risk factors and outcome of bile leak after liver transplantation.We undertook a retrospective study patients who underwent transplantation in our institution between January 2010 2014. The characteristics survival rate with or without were compared.Bile was observed sixteen (2.7% total number transplanted). Total operating time duct reconstruction technique (duct-to-duct anastomosis Rouxen-Y cholangiojejunostomy) found to differ significantly univariate (p = 0.001 0.024,...
When scheduling tasks for field-deployable systems, our solutions must be robust to the uncertainty inherent in real world. Although human intuition is trusted balance reward and risk, humans perform poorly risk assessment at scale complexity of world problems. In this paper, we present a decision aid system that helps operators diagnose source manage temporal The core conflict-directed relaxation algorithm, called Conflict-Directed Chance-constraint Relaxation (CDCR), which specializes...
Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) inhibits their translation. APP αSYN can cause neurodegeneration when aggregates induce neurotoxicity. Therefore, promising drug candidate for neurodegenerative diseases, including Alzheimer's disease Parkinson's disease. Posiphen's safety has been demonstrated three independent phase I clinical trials. Moreover,...
The linear motor feed system can realize high-precision motion with high-speed and high-acceleration, which has a broad application in machine tools. In its unique zero transmission structure, the is connected directly mechanical system. thrust harmonics other disturbances act on mover directly, makes tracking fluctuation more prominent. traditional accuracy repeatability of positioning cannot reflect precision process movement. this paper, novel evaluation method takes dynamic as index...
Abstract Background Mediastinal venous aneurysm is a very rare disease and can be easily misdiagnosed. Patients are often asymptomatic while of large size with adjacent structures oppressed lead to discomfort. The surgical treatment for vessels complex challenging. Case presentation We reported 52-year-old man mediastinal mass who received operation on July 2019 in our hospital. Left innominate vein was diagnosed during superior vena cava involved. resected pericardium taken repair part wall...
Two ideas have gained traction in research the robotics planning community. Activity has become popular where a library of predefined manipulation vehicle state is accessible, and commonly used for missions with complex goal specifications. Another focus been chance-constrained programming as method providing robust motion planning, which probability failure bounded. A combination two would allow satisfaction directives. However, to perform activity we must be able provide probabilistic...
Aim The aim of the present study was to evaluate risk factors and outcomes gastrointestinal perforation post‐liver transplantation. Patients Methods Eleven patients were found have complications as a result transplantation at our centre from M ay 2008 F ebruary 2014. Seven these selected for statistical analysis. Each patient randomly matched with six recipients in age (± 10 years), primary disease sex. Factors, including cold ischaemic time, blood loss volume, previous hepatobiliary surgery...
Abstract Rationale: Invasive thymoma with intraluminal tumor thrombus may cause pulmonary artery if the shed off during operation. However, there is no clinical case report focused on such complication. Patient concerns: A 40-year-old woman presented repeated chest pain. Diagnosis: Chest computer tomography showed huge mediastinal mass. Postoperative pathology revealed type B2 and B3 thymoma, as main type. Interventions: The patient underwent resection through midline sternotomy in our...
The title complex, C24H10Fe4O12S3, contains two Fe2(PhS)(CO)6 subclusters connected through an inorganic spiro μ4-S atom. Each iron atom is coordinated by three carbonyl C atoms [Fe—C 1.786 (9)–1.826 (9) Å], one thiophenyl S [Fe—S 2.267 (2)–2.286 (2) μ4–S 2.235 (2)–2.249 and Fe—Fe bond [2.526 (16), 2.532 (16) in a distorted octahedral geometry.
Intrahepatic pancreatic pseudocyst (IHPP) is an extremely rare complication of acute pancreatitis, with only a few cases previously described in the literature. To best our knowledge, IHPP Budd-Chiari syndrome (BCS) has not yet been described.A 35-year-old male presented abdominal pain, vomiting and anorexia, followed by severe swelling lower body after 4 d. The morphological assessment (using computed tomography revealed presence huge cyst 18.28 cm × 10.34 under liver capsule accompanied...
By analyzing the module and concrete items of risks in ship pilotage, applying Grey theory analysis, brings forward Theory Analysis Model pilotage Moreover, fuzzy function is taken analysis relative risk factors, achieving optimal relational coefficient piloting finally obtaining degree taxis. As indicated computing result model, Relational can ensure results that are more practical.
In planning and scheduling, solving problems with both state temporal constraints is hard since these may be highly coupled. Judicious orderings of events enable solvers to efficiently make decisions over sequences actions satisfy complex hybrid specifications. The ordering problem thus fundamental planning. Promising recent works have explored the as search, incorporating a special tree structure for efficiency. However, such approaches only reason partial order Having observed that an...