A5044798430- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Anesthesia and Pain Management
- COVID-19 and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition, Genetics, and Disease
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Resilience and Mental Health
- Health and Well-being Studies
- Nausea and vomiting management
- Neuroscience of respiration and sleep
- SARS-CoV-2 detection and testing
- Genetic Associations and Epidemiology
- Curcumin's Biomedical Applications
- Artificial Intelligence in Healthcare and Education
- Acute Kidney Injury Research
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
First Affiliated Hospital of Wenzhou Medical University
2017-2024
Wenzhou Medical University
2017-2024
Chengdu University
2023-2024
Sixth Affiliated Hospital of Kunming Medical University
2021
Kunming Medical University
2021
Chinese Academy of Sciences
2020
Institute of Oceanology
2020
Shanghai University of Traditional Chinese Medicine
2019
Abstract Arterial stiffness is a critical factor in cardiovascular and cerebrovascular events, yet clinical practice lacks specific therapeutic targets biomarkers for its assessment. Hyperlipidemia closely correlates with arterial stiffness, we observed elevated CCAAT/enhancer-binding protein β (C/EBPβ) expression atherosclerotic mouse walls. As the medial layer predominantly consists of vascular smooth muscle cells (VSMCs), C/EBPβ‘s role VSMCs under hyperlipidemia remains unclear. Our...
The aim of this study was to compare the periprosthetic BMD changes around Tri-Lock "Bone Preserving Stem" with other two common and longer stems (Corail Summit) after THA.It a retrospective cohort followed patients underwent total hip arthroplasty from January 2013 December 2015. They were selected Janaury 2020. Patients without osteoporosis replacements three aimed included. Among 138 included, 49 received stem, 44 Corail 45 Summit stem. evaluated by Dual energy X-ray absorptiometry (iDXA)...
Allergic contact dermatitis (ACD) is one of the most common skin diseases caused by hapten-modified proteins. Metformin, a drug commonly prescribed for type II diabetes, has been demonstrated to have various biological functions beyond its antidiabetic effects. However, role in ACD remains unknown. In present study, we found that metformin reduced production nitric oxide (NO) and level proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6...
Background/Aims: Interleukin-1β (IL-1β) is one of the critical inflammatory factors during atherogenesis. CCAAT/enhancer binding proteins β (C/EBPβ), a regulator IL-1β production, recently been evidenced as key player in development atherosclerosis. However, mechanisms how C/EBPβ regulates production are unclear. In this study, we aimed to explore role regulating macrophages after oxidized low-density lipoprotein (ox-LDL) exposure and underlying mechanisms. Methods: RAW264.7 were treated...
To investigate post-traumatic growth induced by COVID-19 pandemic in certain Yunnan residents and to analyze its influencing factors. A total of 581 permanent province completed the electronic questionnaire from 18 April 2020 26 2020. Logistic regression analysis showed that educational levels, self-perceived health status, family history infectious diseases, personality frequency going through related news were factors PTG (P < 0.05). As a traumatic event, threat may enable some people gain...
Abstract White‐coat hypertension (WCH) is associated with increased cardiovascular risks. To investigate the relationship between WCH and left ventricular hypertrophy (LVH), authors recruited 706 participants who underwent anthropometric measurements, blood laboratory analysis, 24h ambulatory pressure monitoring (ABPM), echocardiography. The defined as elevated office BP but normal ABPM over 24h, daytime, nighttime periods. compared proportion of LVH true normotension (NT) population,...
Abstract Objective To identify novel candidate genes whose expression is associated with bone mineral density (BMD) and body lean mass (LM) in children. Methods A tissue-specific transcriptome-wide association study (TWAS) was conducted utilizing a large-scale genome-wide (GWAS) dataset BMD LM involving 10,414 participants. The measurement of phenotypes made based on total-body dual-energy X-ray absorptiometry (TB-DXA) scans. TWAS by using FUSION software. Reference panels for muscle...
To investigate the correlation between anxiety and related factors of international students in Wenzhou under epidemic COVID-19. International from were selected as subjects. A self-made student source questionnaire self-assessment scale used for research. Anxiety studying outbreak COVID – 19. Self-rating Statistical methods this Under COVID-19 epidemic, degree is to about getting infected by virus, examination Stress, difference life standard significant. Thus, intervention essential.
Aims: This study aimed to identify potential therapeutic targets in the progression from non-alcoholic fatty liver disease (NAFLD) hepatocellular carcinoma (HCC), with a focus on genes that could influence development and progression. Background: Hepatocellular carcinoma, significantly driven by disease, represents major global health challenge due late-stage diagnosis limited treatment options. utilizes bioinformatics analyze data GEO TCGA, aiming uncover molecular biomarkers bridge NAFLD...
Abstract With the rapid development of grid interconnection and large-scale integration renewable energy, number key features in power system is very large. To proactively monitor status future grids, it necessary to extract that comprehensively reflect their operation modes from operational data. This paper presents a feature selection method for based on semi-supervised learning. The designed consider dataset future-state grid. efficient eigenspace model manifold regularization can be used...
Background and aims: Coronary obstruction following plaque rupture is a critical pathophysiological change in the progression of stable angina (SAP) to acute coronary syndrome (ACS). The accumulation platelets various inflammatory cells on apoptotic endothelial key factor arterial after rupture. Through single-cell sequencing analysis (scRNA-seq) plaques from SAP ACS patients, we identified significant changes annexin V P-selectin glycoprotein ligand 1 pathways. Staphylococcal...
Abstract Background Acute kidney injury (AKI) is a major complication that occurs following an operation. Therefore, there increasing need to discover new predictors of AKI. We hypothesized the preoperative neutrophil‐to‐lymphocyte ratio (NLR) was associated with postoperative AKI and in‐hospital mortality noncardiac surgery. Methods This retrospective observational study patients who underwent surgery at Sichuan University West China Hospital from 2018 2020. Multivariable logistic...
Background Brachial-ankle pulse wave velocity (baPWV) is an important clinical indicator of aortic stiffness and a risk predictor cardiovascular disease associated with obesity. However, whether body mass index (BMI) baPWV remains controversial. In our study, fat-related indicators, including BMI, fat rate (BFR), volume (BFV), waist circumference (WC) were examined from healthy volunteers. We investigated the correlation these indicators also assessed has potential to predict...
To investigate the protective effect of curcumin analogue L6H4 on kidney from type 2 diabetic rats.Twenty-four SPF male SD rats were randomly divided into 3 groups(n=8):normal control group(NC),diabetes mellitus group(DM) and DM+L6H4-treatment group(DT). After fed with high-fat diet for 4 weeks, both DM DT groups injected streptozotocin intraperitoneally to induce diabetes models. The in group given by gavage at dose 0.2 mg/kg·d 8 weeks. treatment, 24 h urinary protein, fasting blood glucose...
<sec> <b>What is already known on this topic?</b> </sec><sec> Contact tracing and testing with isolated medical care of identified cases a key strategy for interrupting chains transmission COVID-19 reducing mortality associated COVID-19. At the early phases pandemic, due to test capacity limitations, case finding often started from suspected cases. added by report?</b> The index patient infected 74 individuals who were close contacts that through contact tracing, exposed monitored in...