A5013753494- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Osteoarthritis Treatment and Mechanisms
- Laser Applications in Dentistry and Medicine
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Tissue Engineering and Regenerative Medicine
- Congenital Anomalies and Fetal Surgery
- Dental Trauma and Treatments
- Knee injuries and reconstruction techniques
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Photoreceptor and optogenetics research
- E-commerce and Technology Innovations
- Bone Tissue Engineering Materials
- Pharmacological Effects and Toxicity Studies
- Healthcare Decision-Making and Restraints
- Traumatic Brain Injury and Neurovascular Disturbances
- Sarcoma Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Ocular and Laser Science Research
Hospital Sírio-Libanês
2017-2024
Insper
2017-2020
University of California, Los Angeles
2020
Centro Universitário Serra dos Órgãos
2015
To reduce morbidity to cleft patients, new approaches have been developed and here, we report for the first time use of deciduous dental pulp stem cells (DDPSC) associated with a hydroxyapatite-collagen sponge (Bio-Oss Collagen® 250 mg, Geistlich) closing alveolar defects during secondary eruption, further comparing these results historical controls. Six aged 8 12, were selected. Autologous DDPSC isolated from each patient, then biomaterial this bone tissue engineered set was used fill...
Background: Cartilage restoration is a desperately needed bridge for patients with symptomatic cartilage lesions. Chondral lesion pathology high prevalence, reaching as much 63% of general population and 36% among athletes. Despite autologous chondrocyte implantation versatility, it still fails to fully reproduce hyaline articular characteristics. Mesenchymal stem cells (MSCs) may be isolated from various known tissues, including discarded fragments at arthroscopy such synovial membrane....
Chondral lesion is a pathology with high prevalence, reaching as much 63% of general population and 36% among athletes. The ability human Dental Pulp Stem Cells (DPSCs) to differentiate into chondroblasts in vitro suggests that this stem cell type may be useful for tissue bioengineering. However, we have yet identify study large animal models which DPSCs were used repair articular cartilage. Therefore, aimed describe novel treatment cartilage on model.Mesenchymal cells (MSC) obtained from...
Dental pulp stem cells (DPSCs) can undergo several types of differentiation, including osteogenic differentiation. One osteogenesis-inducing factor that has been previously described is in vitro low-power laser irradiation cells. Laser promotes the acceleration bone matrix mineralization cell strain. However, no consensus exists regarding dose and treatment time. We used DPSC strains from cleft lip palate patients because new tissue engineering strategies have DPSCs preclinical clinical...
A new trend in the treatment for alveolar clefts patients with cleft lip and palate involves use of bone tissue engineering strategies to reduce or eliminate morbidity associated autologous grafting. The mesenchymal stem cells-autologous cells obtained from tissues such as marrow fat-combined various biomaterials has been proposed a viable option patients. However, invasive procedures are necessary obtain these two sources. To donor site morbidity, noninvasive cell sources umbilical cord,...
Mesenchymal stem cells (MSCs) have been studied as a promising type of cell for use in therapies because their ability to regulate the immune response. Although they are classically isolated from bone marrow, many studies sought isolate MSCs noninvasive sources. The objective this study was evaluate how dental pulp human exfoliated deciduous teeth (SHED) and fragments orbicularis oris muscle (OOMDSCs) behave when treated with an inflammatory IFN-γ stimulus, specifically regarding...
A chondral injury is a limiting disease that can affect the quality of life and be an economic burden due to cost immediate treatment loss in work productivity. If left untreated, such may progress osteoarthritis, degenerative debilitating joint characterized by pain functional impairment. Mesenchymal stromal cells (MSCs), which have immune-modulatory properties ability differentiate into chondroblasts osteoblasts, are predictable source for cartilage injuries. This article presents tools...
Physical characteristics and practical properties have made lasers of interest for biomedical applications. Effects low-level on biological tissues could occur or be measurable depending cell type, presence a pathologic process whether the cells are in an adverse environment. The objective this work was to evaluate survival, morphology filamentation E. coli proficient deficient repair oxidative DNA lesions exposed red infrared submitted hyperosmotic stress. Wild type endonuclease VIII...
Background Traumatic brain injury (TBI) is one of the most important causes acquired structural epilepsy, post-traumatic epilepsy (PTE), however, efficient preventative measures and treatment are still not available to patients. Preclinical studies indicated biperiden, an anticholinergic drug, as a potential drug modify epileptogenic process. The main objective this clinical trial evaluate efficacy biperiden antiepileptogenic agent in patients that suffered TBI. Methods This prospective...
Ventilator-associated tracheobronchitis is a common condition among invasively ventilated patients in intensive care units, for which the best treatment strategy currently unknown. We designed VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) trial assess whether watchful waiting antibiotic noninferior routine ventilator-associated regarding days free of mechanical ventilation.
RESUMO Contexto A traqueobronquite associada ao ventilador é uma condição comum entre pacientes ventilados invasivamente em unidades de terapia intensiva, para a qual se desconhece atualmente melhor estratégia tratamento. Desenhamos o estudo VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) avaliar tratamento antibiótico espera vigilante não inferior rotina relação aos dias sem mecânico. Métodos O um randomizado, controlado, aberto e multicêntrico...
Abstract Background Bone reconstruction in congenital craniofacial differences, which affect about 2–3% of newborns, has long been the focus intensive research field bone tissue engineering. The possibility using mesenchymal stromal cells regenerative medicine protocols opened a new investigation aimed at finding optimal sources multipotent that can be isolated via non-invasive procedures. In this study, we analyzed whether levator veli palatini muscle fragments, readily obtained manner...
Abstract Background. Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus intensive research field bone tissue engineering. The possibility using mesenchymal stem cells regenerative medicine protocols opened a new investigation aimed at finding optimal sources multipotent that can be isolated via non-invasive procedures. Here we analysed whether levator veli palatini muscle fragments, readily obtained manner during surgical...
Abstract Background. Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus intensive research field bone tissue engineering. The possibility using mesenchymal stromal cells regenerative medicine protocols opened a new investigation aimed at finding optimal sources multipotent that can be isolated via non-invasive procedures. In this study we analysed whether levator veli palatini muscle fragments, readily obtained manner...