A5016550582- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trypanosoma species research and implications
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- Galectins and Cancer Biology
- Liver Disease and Transplantation
- Intensive Care Unit Cognitive Disorders
- Blood transfusion and management
- Advances in Oncology and Radiotherapy
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Clinical Reasoning and Diagnostic Skills
- Heparin-Induced Thrombocytopenia and Thrombosis
- Nosocomial Infections in ICU
- Viral Infections and Immunology Research
- Transplantation: Methods and Outcomes
- Climate Change and Health Impacts
- Studies on Chitinases and Chitosanases
- Hospital Admissions and Outcomes
- Appendicitis Diagnosis and Management
- Long-Term Effects of COVID-19
- Signaling Pathways in Disease
Hospital Alemão Oswaldo Cruz
2019-2024
Universidade Federal de São Paulo
2020
Hospital Israelita Albert Einstein
2013-2019
Fundação Oswaldo Cruz
2004-2011
Albert Einstein College of Medicine
2009
The objective of this study was to identify the initial value blood lactate that best correlates with 28-day mortality in resuscitated septic shock patients. This a retrospective cohort including 443 patients admitted an intensive care unit (ICU) severe sepsis or from emergency department. A receiver-operating characteristic (ROC) curve drawn obtain cutoff for associated mortality. Patients were then dichotomized according chosen cutoff, and sensitivity, specificity, positive negative...
Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% Trypanosoma cruzi–infected individuals develop this severe symptomatic form the disease, characterized by intense inflammatory response accompanied fibrosis heart. We performed an extensive microarray analysis hearts from mouse model disease and identified significant alterations expression ∼12% sampled genes. Extensive up-regulations were associated with immune-inflammatory responses...
Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and fibrosis. We have previously shown that bone marrow mononuclear cell (BMC) transplantation improves inflammation, fibrosis, ventricular diameter hearts mice chronic Chagas disease. Here we investigated the transcriptomic recovery induced by BMC therapy comparing transcriptomes control, chagasic, transplanted mice. Out 9390 unique genes...
Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, a major cause of heart failure in Latin America. It disease for effective treatment its advanced clinical forms lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation reducing inflammation and fibrosis mouse model Chagas disease. The present study used magnetic resonance imaging to assess changes cardiac morphology infected mice after therapy with BMCs. Serial BMC-treated...
Liver failure patients have traditionally been empirically transfused prior to invasive procedures. Blood transfusion is associated with immunologic and nonimmunologic reactions, increased risk of adverse outcomes high costs. Scientific evidence supporting empirical lacking, the best approach for blood procedures in cirrhotic has not established so far. The aim this study compare three strategies (routine coagulation test-guided – ordinary or restrictive, thromboelastometry-guided) central...
Objective Physician shift schedules are regularly created manually, using paper or a shared online spreadsheet. Mistakes not unusual, leading to last minute scrambles cover shift. We developed web-based scheduling system and mobile application tool facilitate both the monthly exchanges between physicians. The primary objective was compare physician satisfaction before after implementation. Methods Over 9-month period, three surveys, 4-point Likert type scale were performed assess...
Severe sepsis and septic shock represent a major healthcare challenge. Much of the improvement in mortality associated with is related to early recognition combined timely fluid resuscitation adequate antibiotics administration. The main goals include intravascular replenishment, maintenance perfusion pressure oxygen delivery tissues. To achieve those goals, responsiveness evaluation complementary interventions - i.e. vasopressors, inotropes blood transfusion may be necessary. This article...
Introduction: The human bocavirus (HBoV) is an emerging parvovirus discovered in 2005. It has been identified children different parts of the world. Data suggest that HBoV may be etiological agent responsible for respiratory tract diseases, especially and immunocompromised hosts. can also cause gastrointestinal symptoms, such as diarrhea vomiting. not confined to its presence secretions, serum stool samples this virus systemic illness, although it seems very rare. Currently, detected only by...
Key Clinical Message Approximately 25–50% of septic patients develop disseminated intravascular coagulation. The thromboelastometry evaluates whole blood clot formation and dissolution in real time has been considered for management bleeding diverse clinical conditions. We present a case thromboelastometry‐guided shock patient with overt coagulation ( DIC ).
Savioli, Felicio MD, MSc; Rocha, Leonardo PhD; Góis, Aécio Nakano, Luis Carlos PhD Author Information
Rocha, Daniele1; Nóbrega de Lucena, Bruno Melo1; Muller Bernz, Lívia1; Leonardo2; Santos, Bento1; Almeida, Márcio1 Author Information