A5045512021- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Psoriasis: Treatment and Pathogenesis
- Sleep and Wakefulness Research
- Sleep and related disorders
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Reproductive System and Pregnancy
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Mast cells and histamine
- Viral Infections and Vectors
- Sphingolipid Metabolism and Signaling
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
Brigham and Women's Hospital
2023-2025
Harvard University
2023-2025
Universidade da Região de Joinville
2024
Universidade de São Paulo
2013-2023
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. Antiamyloid antibody treatments modestly slow progression in mild dementia due to AD. Emerging evidence shows that homeostatic dysregulation of brain immune system, especially orchestrated by microglia, plays an important role onset and progression. Thus, a major question how modulate phenotype function microglia treat Xenon (Xe) gas noble used human patients as anesthetic neuroprotectant for treating injuries. Xe...
Neuroinflammation plays a crucial role in traumatic brain injury (TBI), contributing to both damage and recovery, yet no effective therapy exists mitigate central nervous system (CNS) promote recovery after TBI. In the present study, we found that nasal administration of an anti-CD3 monoclonal antibody ameliorated CNS behavioral deficits mouse model contusional Nasal induced population interleukin (IL)-10-producing regulatory T cells (Treg cells) migrated closely contacted microglia. Treg...
Cigarette smoke-induced chronic obstructive pulmonary disease is a very debilitating disease, with high prevalence worldwide, which results in expressive economic and social burden. Therefore, new therapeutic approaches to treat these patients are of unquestionable relevance. The use mesenchymal stromal cells (MSCs) an innovative yet accessible approach for acute diseases, mainly due its important immunoregulatory, anti-fibrogenic, anti-apoptotic pro-angiogenic. Besides, the adjuvant...
SUMMARY Leishmania ( L. ) amazonensis [ ] is widely distributed in Brazil and its symptomatic infections usually lead to few localized lesions sometimes diffuse cutaneous form, with nodules throughout the body, anergy parasite antigens poor therapeutic response. The variability of these manifestations draws attention need for studies on pathophysiology infection by this species. In study, we analysed course immunological aspects BALB/c C57BL/6 strains, both susceptible, but displaying...
NLRP3 inflammasome [NLR (nucleotide-binding domain, leucine-rich repeat containing protein) Pyrin-domain-containing 3 ] functions as an innate sensor of several PAMPs and DAMPs (pathogen- damage-associated molecular patterns). It has been also reported a transcription factor related to Th2 pattern, although its role in the adaptive immunity controversial, mainly because studies were performed using gene deletion approaches. In present study, we have investigated gain-of-function context...
Multiple sclerosis (MS) is an autoimmune and neuroinflammatory disease characterized by demyelination of the Central Nervous System. Immune cells activation release pro-inflammatory cytokines play a crucial role in modulation, decisively contributing to neurodegeneration observed MS experimental encephalomyelitis (EAE), widely used animal model. Synthetic glucocorticoids, commonly treat attacks, have controversial effects on neuroinflammation cognition. We sought verify influence...
Abstract Cellular therapy with mesenchymal stem cells (MSCs) is a huge challenge for scientists, as little translational relevance has been achieved. However, many studies using MSCs have proved their suppressive and regenerative capacity. Thus, there still need better understanding of biology the establishment newer protocols, or to test unexplored tissue sources. Here, we demonstrate that murine endometrial-derived (meMSCs) suppress Experimental Autoimmune Encephalomyelitis (EAE)....
OBJECTIVES: FTY720 modulates CD4 + T cells by the augmentation of regulatory cell activity, secretion suppressive cytokines and suppression IL-17 Th17 cells.To further understand process graft rejection/acceptance, we evaluated skin allograft survival associated events after treatment.METHODS: F1 mice (C57BL/6xBALB/c) C57BL/6 were used as donors for recipients transplantation, respectively.The transplanted either not treated or with gavage 21 days to evaluate survival.In another set...