A5049914658- Asthma and respiratory diseases
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Genetics and Neurodevelopmental Disorders
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Safe Handling of Antineoplastic Drugs
- RNA Interference and Gene Delivery
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Inhalation and Respiratory Drug Delivery
- Medical Device Sterilization and Disinfection
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- Autism Spectrum Disorder Research
- Public Health in Brazil
- Respiratory and Cough-Related Research
- Peptidase Inhibition and Analysis
- Anesthesia and Neurotoxicity Research
- SARS-CoV-2 and COVID-19 Research
Universidade de São Paulo
2018-2024
University of Groningen
2019-2024
University Medical Center Groningen
2020-2024
Helmholtz Zentrum München
2024
Republic Klaipeda Hospital
2021
Abstract The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses – the severe acute respiratory syndrome 2 (SARS-CoV-2) discovered in December 2019 city Wuhan (Hubei Province, China). Remarkably, COVID-19 has rapidly spread across all continents and turned into public health emergency, which was ultimately declared as pandemic World Health Organization (WHO) early 2020. SARS-CoV-2 presents similar aspects to other members family, mainly regarding...
Parasympathetic neurons in the airways control bronchomotor tone. Increased activity of cholinergic are mediators airway hyperresponsiveness (AHR) asthma, however, mechanisms not elucidated. We describe remodeling neuronal network asthmatic driven by brain-derived neurotrophic factor (BDNF) and Tropomyosin receptor kinase B (TrkB). Human bronchial biopsies were stained for marker vesicular acetylcholine transporter (VAChT). lung gene expression single nucleotide polymorphisms (SNP)...
Multiple sclerosis (MS) is an autoimmune and neuroinflammatory disease characterized by demyelination of the Central Nervous System. Immune cells activation release pro-inflammatory cytokines play a crucial role in modulation, decisively contributing to neurodegeneration observed MS experimental encephalomyelitis (EAE), widely used animal model. Synthetic glucocorticoids, commonly treat attacks, have controversial effects on neuroinflammation cognition. We sought verify influence...
Alteration of airway neuronal function and density bidirectional interaction between immune cells sensory peripheral nerves have been proposed to trigger perpetuate inflammation that contribute asthma severity. To date, few studies analysed neuroplasticity neuroinflammation in tissue asthmatic individuals. We hypothesized the presence these phenomena would be a pathological feature fatal asthma. quantified expression pan-neuronal marker PGP9.5 sensory-derived neuropeptide calcitonin...
Allergic asthma is one of the most common chronic disease in children, and can also prevail into adulthood. Several independent studies found that growing up a rural environment has protective effect on reducing their risk developing allergies allergic asthma. A concerted effort been made to elucidate underlying cause this effect, but role macrophages not fully understood thus requires further investigation. We hypothesize repeated exposure farm primes innate immune system, specifically...
<b>Background:</b> Abnormal neuronal activity contributes to symptoms of allergic asthma, where increased cholinergic tone is observed. Neurotrophins such as brain-derived neurotrophic factor (BDNF) are target-derived growth factors and increasingly recognized important in asthma. Here we hypothesized that there an density asthmatic airways mediated by BDNF signaling via its receptor TrkB. <b>Methods:</b> Human bronchial biopsies were stained for the marker vesicular acetylcholine...
<b>Background:</b> Neuroplasticity in the lungs is increasingly recognized as a pathological feature of asthma. Plasticity efferent cholinergic airway neurons has been shown to occur human asthma and correlate with hyperresponsiveness. Despite being widely prescribed, little known regarding effects synthetic glucocorticoids (sGC) on from airways whether this could halt process neuroplasticity. <b>Methods:</b> We applied 50-day pluripotent stem cell (hPSC) – derived peripheral neuron...
<b>Background:</b> Airway neuroplasticity and neurogenic inflammation are part of asthma pathogenesis. To date, few articles have explored these phenomena in human and, to our knowledge, quantitative studies assessing fatal (FA) lungs never been performed. <b>Methods:</b> We used obtained from FA cases autopsied at Sao Paulo University Academic Hospital, compared tissue individuals that died non-pulmonary causes. By immunohistochemistry, we quantified peripheral nerves using PGP 9.5, as a...
<b>Background:</b> Chronic stress triggers asthma exacerbations and is deleterious to many other diseases, but the mechanisms remain elusive. We hypothesize that, given exposure releases a multitude of molecules capable modifying immune neuronal function, exacerbation would result from altered neuroimmune communication in lungs. <b>Aims objectives:</b> 1) To establish model for chronic 2) describe linking airway inflammation <b>Methods:</b> applied 12-day unpredictable (CUS) paradigm...
Abstract Background Many people chronically infected with the hepatitis C virus (HCV) are not aware of their infection. The benefit screening for HCV is earlier treatment antiviral medications, which highly effective and can prevent long-term complications chronic such as cirrhosis, liver cancer, death. This study aimed to examine prevalence infection its risk factors among primary health care patients. Methods was carried out in centre seaport Klaipeda, Lithuania. Patients were invited...