A5045785529- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Psychedelics and Drug Studies
- Anesthesia and Neurotoxicity Research
- Nicotinic Acetylcholine Receptors Study
- Down syndrome and intellectual disability research
- Pancreatic function and diabetes
- Tryptophan and brain disorders
- Effects and risks of endocrine disrupting chemicals
- Nigella sativa pharmacological applications
- Forensic Toxicology and Drug Analysis
- Breastfeeding Practices and Influences
- Heavy Metal Exposure and Toxicity
- Dementia and Cognitive Impairment Research
- Mercury impact and mitigation studies
- Air Quality and Health Impacts
- Bioactive Compounds and Antitumor Agents
- Coffee research and impacts
- Hypothalamic control of reproductive hormones
- Per- and polyfluoroalkyl substances research
- Metabolism, Diabetes, and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
Universidade de São Paulo
2018-2025
Hospital Universitário da Universidade de São Paulo
2024
Universidade Federal de Alfenas
2017
The tetraprenylated benzophenone 7-epiclusianone (7-epi) is a substance isolated from the fruits of Garcinia brasiliensis and in vitro studies have demonstrated that 7-epi effective against Schistosoma mansoni adult worms.Here we report vivo evaluation its pharmacokinetic healthy infected mice.In this work, assayed schistosomicidal activity at dose 100 mg/kg 300 body weight/day S. experimentally mice. Besides, two groups animals were treated detailed analysis plasma samples was performed by...
Environmental tobacco smoke (ETS) exposure during brain development has been associated with several disorders, such as depression, anxiety, sudden infant death syndrome, and the predisposition to addiction. The endocannabinoid system plays an essential role in neuronal development. We investigated effects of early postnatal ETS on different regions. C57BL/6 J mice were exposed that was generated from 3R4F cigarettes day 3 (P3) P14. Receptors enzymes assessed infancy, adolescence, adulthood...
Abstract We verified if cocaine‐induced peripheral activation might disrupt [ 18 F]FDG brain uptake after a cocaine challenge and suggested an optimal protocol to measure metabolic alterations in mice. C57Bl/6 male mice were injected with randomly separated into three groups. Groups 1 2 kept conscious administration 5 min received saline or (20 mg/kg). The animals group ( n = 5) then evaluated the open field for 30 those from 6) alone home cage same period. Forty‐five minutes administration,...
Abstract Despite evidence of the beneficial effects cannabidiol (CBD) in animal models cocaine use disorder (CUD), CBD neuronal mechanisms remain poorly understood. This study investigated treatment on brain glucose metabolism, a CUD model, using [ 18 F]FDG positron emission tomography (PET). Male C57Bl/6 mice were injected with (20 mg/kg, i.p.) every other day for 9 days, followed by 8 days administration (30 i.p.). After 48 h, animals challenged cocaine. Control received saline/vehicle....
Abstract Background Down syndrome (DS) is associated with mitochondrial dysfunction leading to higher levels of oxidative stress and cell degeneration. This fact, together the overexpression AD‐related genes in trisomy 21, increases risk developing Alzheimer's disease (AD). Thus, it important look for interventions that could prevent damage before symptoms occur. Physical activity a non‐pharmacological intervention provides an anti‐inflammatory response neurotrophic factors are beneficial...
Abstract Background Imaging biomarkers have helped to reconceptualize Alzheimer's disease pathophysiology. More specifically, positron emission tomography (PET) radiopharmaceuticals for non‐invasively assessing amyloid‐beta (Aβ) plaques, glucose metabolism, and glial reactivity allow tracking progression in a temporally ordered manner. However, whether transgenic models recapitulate biomarker‐related changes remains elusive. Here, we longitudinally evaluated Aβ, using PET amyloid rat model....
Abstract Background Emerging preclinical studies show that cannabidiol (CBD) has neuroprotective and anti‐inflammatory effects may have the potential to improve Alzheimer's disease (AD) therapy. Although much progress been made in understanding pathology of AD, its multifactorial nature can't be mimicked a single model. In order results search for AD better interventions, aim this study is compare CBD two animal models sex‐dependent manner. Method Male female Ts65Dn 3xTg‐AD mice were used...
Abstract Background Imaging biomarkers have helped to reconceptualize Alzheimer’s disease pathophysiology. More specifically, positron emission tomography (PET) radiopharmaceuticals for non‐invasively assessing amyloid‐beta (Aß) plaques, glucose metabolism, and glial reactivity allow tracking progression in a temporally ordered manner. However, whether transgenic models recapitulate biomarker‐related changes remains elusive. Here, we longitudinally evaluated Aß, using PET amyloid rat model....
The embryonic stage is the most vulnerable period for congenital abnormalities. Due to its prolonged developmental course, central nervous system (CNS) susceptible numerous genetic, epigenetic, and environmental influences. During embryo implantation, CNS more external influences such as tobacco smoke (ETS), increasing risk delayed fetal growth, sudden infant death syndrome, immune This study aimed evaluate effects of in utero exposure ETS on neuroinflammation offspring pregnant mice...
Abstract Background Individuals with Down Syndrome (DS) have an increased genetic risk for developing Alzheimer’s Disease (AD), due to a higher expression of genes related the pathophysiological development disease and inflammatory process. Brain damage is already substantial when first clinical signs AD appear, it essential study therapeutic alternatives that delay its development. As lithium carbonate has been identified as neuroprotective neuroplastic agent in neurodegeneration, aim this...