A5074317724- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Insect Pest Control Strategies
- Synthesis and Characterization of Heterocyclic Compounds
- Trypanosoma species research and implications
- Synthesis and biological activity
- Banana Cultivation and Research
- Phytochemical compounds biological activities
- Studies on Chitinases and Chitosanases
- Parasites and Host Interactions
- Tryptophan and brain disorders
- Traditional and Medicinal Uses of Annonaceae
- Fungal Plant Pathogen Control
- Click Chemistry and Applications
- Papaya Research and Applications
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
Universidade Federal de Alfenas
2015-2025
Leishmaniasis is a neglected tropical disease with limited therapeutic options characterized by high toxicity, adverse side effects, and growing resistance to existing treatments. In this study, machine learning (ML) methods were employed design evaluate benzophenone xanthone derivatives as potential antileishmanial agents. A dataset of 73 compounds was curated, Quantitative Structure-Activity Relationship (QSAR) models developed using artificial neural networks (ANN), Random Forest (RF),...
Eight native plant extracts from the Brazilian Atlantic Forest, Acacia polyphylla, Allophylus racemosus, Casearia arborea, Duguetia lanceolata, Metrodorea stipularis, Trichilia emarginata, Miconia willdenowii, Mollinedia widgrenii, were screened for potential schistosomicidal activity. The crude ethanolic extract of willdenowii (at a concentration 200 μg/mL) showed most promising results, killing approximately 65% Schistossoma mansoni worms, in comparison to praziquantel. This was then...
The trypanosomatids, such as the protozoan Leishmania spp., have a demand by ergosterol, which is not present in membrane from mammal cells. suppression of synthesis ergosterol would be new target compounds with leishmanicidal activity, and bistriazole has shown trypanocidal activity this mechanism. incidence fungal infections increased at an alarming rate over last decades. This related both to growing population immune-compromised individuals emergence strains that are resistant available...
A fitoterapia é uma prática sociocultural presente ao longo dos anos e utilizada para tratar enfermidades que acometem o ser humano.Nesse contexto, a Annona crassiflora Mart.destaca-
New therapeutic options against leishmaniasis are necessary, especially those of natural origin, like licarin A, a neolignan with activity Leishmania major. The effect A (DL01) and its derivatives (DL03, DL10, DL17 DL21) was evaluated amazonensis promastigotes intracellular amastigotes. Promastigote forms were assayed in different incubation periods the 50% effective concentration (EC50) determined. Cytotoxicity assessed murine peritoneal macrophages by...
Hydroxymethylnitrofurazone (NFOH) is a prodrug of nitrofurazone devoid mutagenic toxicity, with in vitro and vivo activity against Trypanosoma cruzi (T. cruzi) Leishmania. In this study, we aimed to increase the solubility NFOH improve its efficacy T. (Chagas disease) Leishmania species (Leishmaniasis) highly. Two formulations nanocrystals (NFOH-F1 NFOH-F2) were prepared characterized by determining their particle sizes, size distribution, morphologies, crystal properties,...