A5062820656- Nuts composition and effects
- Inflammatory mediators and NSAID effects
- Health, Nursing, Elderly Care
- Hormonal and reproductive studies
- Healthcare Regulation
- Birth, Development, and Health
- Muscle metabolism and nutrition
- Renin-Angiotensin System Studies
- Venomous Animal Envenomation and Studies
- Pregnancy and preeclampsia studies
- Neurological Complications and Syndromes
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Science and Education Research
- Occupational Health and Burnout
- Health Education and Validation
- Nitric Oxide and Endothelin Effects
- Gestational Diabetes Research and Management
- Macrophage Migration Inhibitory Factor
- Heme Oxygenase-1 and Carbon Monoxide
- Organ Transplantation Techniques and Outcomes
- Down syndrome and intellectual disability research
- Abdominal Surgery and Complications
- Morinda citrifolia extract uses
- Healthcare and Venom Research
Faculdade Ceres
2015-2024
Faculdade de Medicina de Marília
2024
Faculdade de Medicina de São José do Rio Preto
2010-2024
Ceres Nanosciences
2023-2024
Ceres
2023-2024
Instituto Tropical de Medicina Reprodutiva
2024
Cochrane
2023
Pontifícia Universidade Católica do Paraná
2023
Universidade Estadual de Montes Claros
2023
Universidade Estadual Paulista (Unesp)
1996-2018
The main side effect of cyclosporine A (CsA), a widely used immunosuppressive drug, is nephrotoxicity. Early detection CsA-induced acute nephrotoxicity essential for stop or minimize kidney injury, and timely chronic critical halting the drug preventing irreversible injury. This study aimed to identify urinary biomarkers We allocated salt-depleted rats receive CsA vehicle 7, 14 21 days evaluated renal function hemodynamics, microalbuminuria, macrophage infiltration, tubulointerstitial...
We assessed in vivo the protective effects and underlying antioxidant anti-inflammatory properties of dry green tee extract (GTE) on glomerular tubular kidney function structure an experimental model gentamicin (GEN)-induced nephrotoxicity. Wistar rats were divided into four groups treated daily for 10 days. The control group received distilled water; GTE 20 μg/g body weight (BW) by gavage; GEN 100 mg/g BW intraperitoneally; GEN+GTE simultaneously, as described above. At beginning end...
Cyclosporine A (CsA)-induced chronic nephrotoxicity is characterized by renal dysfunction and interstitial fibrosis. Early progressive macrophage influx, correlating with latter fibrotic areas, has been associated CsA treatment. This study investigated the role of macrophages, nitric oxide (NO) pathway, oxidative stress on nephrotoxicity.The macrophages were depleted clodronate liposomes. Animals distributed into four groups: vehicle (olive oil for 21 days), 7.5 mg/kg per day (21 plus (5...
Annexin A1 (AnxA1) is an endogenous glucocorticoid regulated protein that modulates anti-inflammatory process and its therapeutic potential has recently been recognized in a range of systemic inflammatory disorders. The effect the N-terminal peptide Ac2-26 AnxA1 on toxic activities Bothrops moojeni crude venom (CV) myotoxin II (MjTX-II) were evaluated using peritonitis rat model. Peritonitis was induced by intraperitoneal injection either CV or MjTX-II, Lys-49 phospholipase A2. Fifteen...
Rheumatoid arthritis (RA) may promote endothelial dysfunction. This phenomenon requires further investigation, especially in collagen-induced (CIA), as it is considered the experimental model most similar to RA. The objectives of this study were identify CIA-induced changes noradrenaline (NE) and acetylcholine (ACh) responses mice aortas that suggest dysfunction these animals. Moreover, we characterize modifications inducible nitric oxide synthase (iNOS) expression cardiac renal tissues...
Abstract Galectin-1 protein (GAL-1) has important anti-inflammatory properties, but related pharmacologic approaches to effectively treat or prevent renal ischaemia and reperfusion injury are highly limited. Here, we investigated the effect of GAL-1 in a ischaemia-reperfusion rat model an vitro hypoxia-reoxygenation with proximal tubular epithelial cell line. In vivo , pretreatment attenuated parameters changed by ischaemia-reperfusion/hypoxia-reoxygenation, recovery function, protecting...
Ischemia-reperfusion (IR) injury results from inflammation and oxidative stress, among other factors. Because of its anti-inflammatory antioxidant properties, the Brazil nut (BN) might attenuate IR renal injury.The aim present study was to investigate whether intake BN prevents or reduces kidney inflammation, improving function decreasing stress.Male Wistar rats were distributed into six groups (N=6/group): SHAM (control), treated with 75 150 mg BN, IR, BN. The procedure consisted right...
Ischemia and reperfusion (IR) is a process inherent to the procedures involved in transplantation of organs that causes inflammation, cell death injury, may lead rejection graft. It possible anti-inflammatory properties Brazil nuts (BN) can mitigate renal injury caused by IR.To investigate whether previous intake BN reduces expression markers after IR.Male Wistar rats were distributed into six groups (N = 6/group): SHAM (control), treated with 75 or 150 mg BN, IR, IR BN. The procedure...
<b><i>Background/Aims:</i></b> The effects of cigarette smoke (CS) on cyclosporine (CsA)-induced nephrotoxicity are poorly studied. This study aims to assess the previous exposure CS CsA nephrotoxicity. <b><i>Methods:</i></b> Rats were either exposed or sham (S) procedures for 10 min twice a day 20 weeks. From 16th 20th week, they received low-salt diet. Beginning with 17th given 2.5 mg/day vehicle (VH) 3 final groups VH/CS, CsA/CS, VH/S, and...
O trauma abdominal é uma lesão súbita e violenta na região abdominal, que apresenta vários padrões de lesão. É o mais recorrente em crianças, acometendo principalmente trato gastrointestinal, sendo potencialmente fatal quando não diagnosticado tratado adequadamente. Deste modo, as técnicas utilizadas para manejo destes pacientes apresentam enigmas desafios os profissionais da saúde. Identificar indicações laparoscopia avaliação diagnóstica pediátrico, a fim definir seus riscos benefícios...
Arthritis has important cardiovascular repercussions. Phenylephrine-induced vasoconstriction is impaired in rat aortas the early phase of adjuvant-induced arthritis (AIA), around 15th day post-induction. Therefore, present study aimed to verify effects AIA on hyporesponsiveness phenylephrine aortas. was induced by intradermal injection Mycobacterium tuberculosis (3.8 mg/dL) right hind paw male Wistar rats (n=27). Functional experiments isolated were carried out 15 days after induction....
This study was conducted to investigate the distribution of placental villous vessels in pregnant women with different degrees hyperglycemia.
O perfil lipídico é avaliado por uma série de exames laboratoriais que incluem a quantificação do colesterol total (CT), da lipoproteína alta densidade (HDL-c), baixa (LDL-c) e triglicerídeos (TG), necessário para analisar os riscos doença cardíaca coronariana, associados com o distúrbio metabolismo dos lipídeos, conhecido como dislipidemia. presente estudo teve objetivo: : verificar alunos ingressaram no curso medicina. As análises foram feitas através questionário IPAQ, níveis HDL, LDL, CT...
The popularity of Morinda Citrifolia Linn (Noni) as a dietary supplement, food functional ingredient, or natural health enhancer is increasing throughout the world.Our study aims to investigate concentrations 10% and 50% Citifolia usage time its renal hepatic toxicity.To this purpose, 42 male wistar rats were distributed into groups: treated for 15 days with concentration 50and 90 50%.Noni juice has been prepared fruit's pulp seeds at diluted in water.The groups presented elevated...
Renal injury induced by rheumatoid arthritis is not clear and may be related to the angiotensin II. We aim investigate adjuvant-induced (AIA) in rat kidney, focusing II/AT
ABSTRACT Introduction: During physical activity, the body diverts blood to essential areas such as skeletal muscle, reducing supply non-essential kidney. Whey protein is one of most widely used supplements in gyms. Objectives: To evaluate renal function and structure rats submitted exercise with without use supplementation. Methods: The was Hydro PRO 2 - Probiotica®. It administered orally (by gavage), diluted mineral water (1.8 g/kg weight, shortly after swimming training). were divided...
A Ibogaína é um alcalóide indólico psicoativo com efeitos estimulantes e alucinógenos o qual derivado da casca raiz do arbusto África Ocidental Tabernanthe iboga, mostra-se uma alternativa promissora no tratamento de dependentes substâncias derivadas ópio por demonstrar afinidade significativa muitos sistemas neurotransmissores. Avaliar os em adultos idosos opióides. Estudo revisão sistemática utilizando as bases dados Pubmed/Medline, LILACS, BVS, SCIELO Cochrane. pesquisa foi conduzida...