A5089595575- S100 Proteins and Annexins
- Antimicrobial Peptides and Activities
- Natural Compound Pharmacology Studies
- Mast cells and histamine
- Piperaceae Chemical and Biological Studies
- Protease and Inhibitor Mechanisms
- Genital Health and Disease
- Neonatal Respiratory Health Research
- Biomarkers in Disease Mechanisms
- Ocular Surface and Contact Lens
- Wound Healing and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Genomics, phytochemicals, and oxidative stress
- Corneal Surgery and Treatments
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Body Contouring and Surgery
- Retinoids in leukemia and cellular processes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ginger and Zingiberaceae research
- Inflammatory mediators and NSAID effects
- Connexins and lens biology
Fundação Padre Albino
2016-2025
Universidade Estadual Paulista (Unesp)
2016-2025
Universidade Federal de São Paulo
1995-2025
Faculdade de Medicina de São José do Rio Preto
2013
Universidade de São Paulo
2011
The incidence of penile cancer varies between populations but is rare in developed nations. Penile associated with a number established risk factors and diseases including phimosis chronic inflammation, human papillomavirus (HPV) infection, poor hygiene smoking. objective this study was to identify genes related type cancer. detection HPV analyzed 47 squamous cell carcinoma samples. DNA detected 48.9% cases. High-risk were present 42.5% cases low-risk 10.6% carcinomas. RaSH approach...
Annexin A1 (AnxA1) is a protein that displays potent anti-inflammatory properties, but its expression in eye tissue and role ocular inflammatory diseases have not been well studied. We investigated the mechanism of action potential uses AnxA1 mimetic peptide (Ac2-26) endotoxin-induced uveitis (EIU) rodent model human ARPE-19 cells activated by LPS. In rats, analysis untreated EIU after 24 48 h or treated with topical applications single s.c. injection Ac2-26 revealed actions on leukocyte...
Objectives To establish the role and effect of glucocorticoids endogenous annexin A1 (AnxA1) pathway in inflammatory arthritis. Methods Ankle joint mRNA protein expression AnxA1 its receptors were analysed naive arthritic mice by real-time PCR immunohistochemistry. Inflammatory arthritis was induced with K/BxN arthritogenic serum +/+ −/− mice; some experiments, animals treated dexamethasone (Dex) or human recombinant a protease-resistant mutant (termed SuperAnxA1). Readouts score, disease...
Abstract Acanthamoeba spp. can cause amoebic keratitis (AK). Chlorhexidine is effective for AK treatment as monotherapy, but with a relative failure on drug bioavailability in the deep corneal stroma. The combination of chlorhexidine and propamidine isethionate recommended current treatment. However, effectiveness depends parasite virulence strains. This study aims to determine potential Garcinia mangostana pericarp extract α-mangostin against triangularis , well infection. minimal...
NF-kB (nuclear factor kappa B) is a transcription composed of two subunits, p50 and p65, which plays key role in the inflammatory process. Melatonin has oncostatic, antiangiogenic antimetastatic properties, some recent studies have indicated an inhibitory effect melatonin on types cancer. This work aims to investigate effects treatment expression NFkB breast liver cancer models.The xenographic model was performed using female Balb/c nude athymic mice injected with MDA-MB-231 cells. The...
Abstract Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities targeting cancer development and progression. Piplartine (PL) is biologically active alkaloid from long peppers that exhibits anti-inflammatory antitumor activity. In the present study, we investigated physical chemical interactions of PL with compounds their effects on cell proliferation migration gene expression inflammatory mediators. Molecular docking data physicochemical...
We assessed in vivo the protective effects and underlying antioxidant anti-inflammatory properties of dry green tee extract (GTE) on glomerular tubular kidney function structure an experimental model gentamicin (GEN)-induced nephrotoxicity. Wistar rats were divided into four groups treated daily for 10 days. The control group received distilled water; GTE 20 μg/g body weight (BW) by gavage; GEN 100 mg/g BW intraperitoneally; GEN+GTE simultaneously, as described above. At beginning end...
Deregulation of VEGFA (Vascular Endothelial Growth Factor A) and NFE2L2 (Nuclear (Erythroid-derived 2)-Like 2), involved in angiogenesis oxidative stress, can lead to thyroid cancer progression. MiR-17-5p miR-612 are possible regulators these genes may promote disorders. In order evaluate the involvement VEGFA, NFE2L2, hsa-miR-17-5p, hsa-miR-612 pathology, we examined tissue samples from colloid goiter, papillary (PTC), a normal thyroid. We found higher levels transcripts protein goiter PTC...
Mast cells (MCs) participate in all stages of skin healing and one their mediators is the Annexin A1 protein (AnxA1), linked to inflammation, proliferation, migration apoptosis processes, but not studied thermal burns yet. Therefore, our objectives were evaluate behavior MCs AnxA1 a second degree burn model, treated or with silver sulfadiazine 1% (SDP 1%) associated macrophages quantification cytokines dosages. counts showed few early repair increased final phases untreated group. The normal...
Rheumatoid arthritis (RA) may promote endothelial dysfunction. This phenomenon requires further investigation, especially in collagen-induced (CIA), as it is considered the experimental model most similar to RA. The objectives of this study were identify CIA-induced changes noradrenaline (NE) and acetylcholine (ACh) responses mice aortas that suggest dysfunction these animals. Moreover, we characterize modifications inducible nitric oxide synthase (iNOS) expression cardiac renal tissues...
Inflammation in the established tumor microenvironment (TME) is often associated with a poor prognosis of breast cancer. Bisphenol A (BPA) an endocrine-disrupting chemical that acts as inflammatory promoter and tumoral facilitator mammary tissue. Previous studies demonstrated onset carcinogenesis at aging when BPA exposure occurred windows development/susceptibility. We aim to investigate repercussions TME gland (MG) during neoplastic development aging. Female Mongolian gerbils were exposed...
Mast cells are present in the eye of chick embryos from 14th day onward, displaying metachromatic granules, mainly iris anterior surface and pectinate ligament. Ultrastructurally these show electron-dense granules a few thin short cytoplasmic projections close contact with fibroblasts. Sometimes contacts extensive, long fibroblast partially involving mast cells. Gap junctions between fibroblasts observed only eyes 16- 20-day-old embryos. These intercellular specializations represented by...
Uveitis is one of the main causes blindness worldwide, and therapeutic alternatives are worthy study. We investigated effects piperlongumine (PL) and/or annexin A1 (AnxA1) mimetic peptide Ac2-26 on endotoxin-induced uveitis (EIU). Rats were inoculated with lipopolysaccharide (LPS) intraperitoneally treated (200 µg), PL 400 or + after 15 min. Then, 24 h LPS inoculation, leukocytes in aqueous humor, mononuclear cells, AnxA1, formyl receptor (fpr)1, fpr2, cyclooxygenase (COX)-2 evaluated ocular...