A5080300902- Bone Metabolism and Diseases
- Oral microbiology and periodontitis research
- Bone health and treatments
- Bone and Dental Protein Studies
- Nitric Oxide and Endothelin Effects
- Glycosylation and Glycoproteins Research
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Alkaline Phosphatase Research Studies
- Endodontics and Root Canal Treatments
- Parathyroid Disorders and Treatments
- Antimicrobial Peptides and Activities
- Proteoglycans and glycosaminoglycans research
- Probiotics and Fermented Foods
- Renin-Angiotensin System Studies
- Vagus Nerve Stimulation Research
- Forensic Toxicology and Drug Analysis
- Traditional and Medicinal Uses of Annonaceae
- Blood Coagulation and Thrombosis Mechanisms
- Sinusitis and nasal conditions
- Maternal and Neonatal Healthcare
- Bone and Joint Diseases
Universidade de São Paulo
2014-2024
Clinics Hospital of Ribeirão Preto
2023
Universidade de Ribeirão Preto
2018-2023
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2018
Fundação de Amparo à Pesquisa do Estado de São Paulo
2018
Fundação Faculdade de Odontologia
2018
Tsurumi University
2015
Finnish Foundation for Alcohol Studies
1988
Chemerin is an adipokine that regulates adipogenesis and metabolic functions of mature adipocytes mainly through the activation chemokine-like receptor 1 (CMKLR1). Elevated levels chemerin have been found in individuals with obesity, type 2 diabetes, osteoporosis. This was identified as inflammatory syndrome marker. Considering association between bone health remains unclear, present study aimed to clarify role pathophysiology loss induced by dyslipidemia, particularly modulating...
Osteoclasts play a key role in the regulation of bone mass and are highly active metabolically. Here we show that metabolic reprogramming toward hexosamine biosynthetic pathway (HBP) is required not only for osteoclast differentiation but also to determine resorption mode during physiological pathological remodeling. We found pharmacological inhibition O-GlcNAc transferase (OGT) significantly reduced protein O-GlcNAcylation differentiation. Accordingly, genetic deletion OGT inhibited...
Abstract Background and Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause bone erosion due to increased osteoclastogenesis. Neutrophils involvement in osteoclastogenesis remains uncertain. Given neutrophil extracellular traps (NETs) act as inflammatory mediators rheumatoid arthritis, we investigated the role of NETs stimulating loss by potentiating during arthritis. Experimental Approach The level synovial fluid from patients was assessed. Bone evaluated...
The NOD-like receptors are cytoplasmic proteins that sense microbial by-products released by invasive bacteria. Although NOD1 and NOD2 functionally expressed in cells from oral tissues play a role triggering immune responses, the of receptor bone resorption modulation osteoclastogenesis is still unclear. We show an experimental model periodontitis with Porphyromonas gingivalis W83, -/- mice showed lower when compared to wild type. Quantitative polymerase chain reaction analysis revealed...
Apical periodontitis is an inflammatory disorder that results from the host immune response to microbial infection through dental pulp, leading alveolar bone destruction. The nod-like receptor 12 (NLRP12) atypical intracellular sensor of NLR family involved in negative regulation several conditions and also osteoclastogenesis. However, role NLRP12 loss induced by bacterial remains unclear. Here we investigated development apical wild-type (WT) knockout (NLRP12 –/– ) mice using micro–computed...
Osteoclasts are specialized cells responsible for bone resorption, a highly energy-demanding process. Focus on osteoclast metabolism could be key the treatment of osteolytic diseases including osteoporosis. In this context, AMP-activated protein kinase α1 (AMPKα1), an energy sensor expressed in osteoclasts, participates metabolic reconfiguration during differentiation and activation. This study aimed to elucidate role AMPKα1 osteoclastogenesis vitro its impact loss vivo. Using...
Bone-loss-related diseases such as rheumatoid arthritis, osteomyelitis, osteoporosis, and periodontitis are associated with high rates of morbidity worldwide. These disorders characterized by an imbalance between the formation activity osteoblasts osteoclasts, leading to bone loss. In this context, we evaluated effect cinnamoyloxy-mammeisin (CNM), anti-inflammatory coumarin found in Melipona scutellaris geopropolis, on key targets related remodeling. present study investigated vitro effects...
The present study examined the hemodynamics [arterial pressure (AP), AP variability (APV), heart rate (HR), and (HRV)], cardiac function (echocardiographycally), myocardial inflammation in Balb/c mice submitted to Periodontitis, through ligation of left first molar, or Sham surgical procedure. protocol indicated that was similar (136 ± 2 vs. 132 3 mmHg Sham), while HR higher with Periodontitis (475 20 412 18 bpm compared their counterparts. APV when evaluated time domain (4.5 0.3 3.4 0.2...
No presente estudo, foi avaliada a atividade do cinamoiloxi-mammeisina (CNM), uma 4-fenil cumarina isolada da geoprópolis brasileira, sobre diferenciação de linfócitos Th17 no desenvolvimento doença periodontal. De acordo com os resultados, administração CNM, reduziu reabsorção óssea dos camundongos periodontite induzida por ligadura, bem como frequência nos linfonodos maxilares. Espera-se que as informações obtidas neste estudo contribuam para o nova droga tratamento
Apical periodontitis is an immune inflammatory response around periapical tissues as a result of pathogens invasion into the root canal. The host immunoinflammatory could determine progression this disease, which involves recruitment cells, and release several cytokines in lesion site. 5-lipoxygenase pathway has been activated some osteolytic diseases due to its capacity interfere proliferation differentiation bone including osteoclasts. As mean understand genes regulation apical...
Objective: Ang II is a pluripotent hormone in vascular smooth muscle cells and stimulates arterial remodeling hypertention. influenses the structure function of cells, plays an important role reactive oxygen species production. Superoxide anions are recognized as mediators intracellular signaling cascades known to participate cardiovascular diseases such arteriosclerosis hypertension. Previous studies reported that production superoxide modulated by many factors including - AT1 receptor...
Objective: Superoxide anions are recognized as mediators of intracellular signaling cascades and known to participate in cardiovascular diseases such arteriosclerosis hypertension. The NADPH oxidase complex the vascular smooth muscle cells consists p22phox, Rac1, Nox1. We previousy cloned a novel molecule interacting with carboxy-terminal domain AT1 receptor, which we named ATRAP (for receptor-associated protein), using yeast two-hybrid strategy. In this study, tested hypothesis that express...
Objective: Previous studies reported that the production of superoxide is modulated by many factors including Ang II - AT1 receptor signaling. One major sources in aorta NADPH oxidase located smooth muscle cells. The complex vascular cells consists p22phox, Rac1, and Nox1. showed carboxy-terminal cytoplasmic domain involved control internalization linking receptor-mediated signal transduction to specific biological response. Design method: We previousy cloned a novel molecule interacting...