A5054233802- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Atherosclerosis and Cardiovascular Diseases
- Rheumatoid Arthritis Research and Therapies
- Whipple's Disease and Interleukins
- Renal Diseases and Glomerulopathies
- Vitamin C and Antioxidants Research
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Adipokines, Inflammation, and Metabolic Diseases
- Complement system in diseases
- Kawasaki Disease and Coronary Complications
- Protein Tyrosine Phosphatases
- Herbal Medicine Research Studies
- Pharmacological Effects of Medicinal Plants
- Viral Infections and Immunology Research
Universidade Federal de Pernambuco
2014-2024
Commiphora leptophloeos is a plant specie usually known for its medicinal purposes in local communities Northeast Brazil. In order to evaluate therapeutic potential, we aimed determine the phytochemical and antimicrobial properties of C. extracts. Thin Layer Chromatography (TLC) was able detect presence phenolic compounds, flavonoids reducing sugars. Three compounds were identified by HPLC described as Gallic, Chlorogenic Protocatechuic acids. On other hand, H1NMR analysis revealed...
Systemic lupus erythemathosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases characterized by an immune balance breakdown chronic inflammation. Several findings link SLE RA development with the complement system ficolin components have emerged as candidates for disease development. Since genetic association studies genes in not yet been conducted a Brazilian population, aim of this study was to determine whether polymorphisms ficolin-1(FCN1) ficolin-2 (FCN2) associated...
Vitamin D receptor is a mediator of immune responses through the action vitamin D, which capable regulate insulin secretion by pancreas. Since polymorphisms in (VDR) gene might modulate function, and thus immunologic response, VDR possibly able to influence predisposition type 1 diabetes mellitus (T1DM). The aim this work was perform an association study among T1DM susceptibility, as well correlation with disease onset. Two hundred four patients 217 controls, from Northeast Brazil, were...
Abstract Osteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite efforts to clarify relationship among and susceptibility develop OP, many associations need be further functionally validated. Besides, some limitations as choice stably expressed reference genes (RG) should overcome ensure quality reproducibility gene expression assays. To our knowledge, validation study for RG OP still missing. We compared levels, using polymerase...
The aim of the present study was to evaluate impact SEMA4A genetic variants on expression sema4A protein and its relation autoimmunity development in Systemic Lupus Erythematosus Rheumatoid Arthritis patients. A total 541 SLE patients, 390 RA patients 607 healthy individuals were genotyped. We also assessed mRNA from whole blood cells vitro production resting activated T lymphocytes as well mature dendritic stratified according their genotypes for SLE/RA associated variants. Our results...
Turner syndrome (TS) is characterized by a set of clinical conditions, including autoimmune/inflammatory diseases and infectious that can compromise patient's quality life. Here we assessed polymorphisms in CTLA-4 +49A/G (rs231775), PTPN22 +1858G/A (rs2476601), MBL2 -550 (H/L) (rs11003125), -221(X/Y) (rs7096206) exon 1 (A/O) women from northeastern Brazil to determine whether within these key immune response genes confer differential susceptibility conditions TS. A case-control genetic...
The role of steroid hormones against infectious diseases has been extensively studied. From immunomodulatory action to direct inhibition microorganism growth, D3 (VD3) and 17β-estradiol (E2), the genetic pathways modulated by them, are key targets for a better understanding pathogenesis respiratory (IRD) such as tuberculosis (TB) coronavirus disease-19 (COVID-19). Currently, world faces two major public health problems, outbreak COVID-19, accounting more than 6 million so far, TB, 1 deaths...