A5036077962- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Cytokine Signaling Pathways and Interactions
- Diabetes Treatment and Management
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Bone health and treatments
- Viral Infections and Immunology Research
- Bone Metabolism and Diseases
- Rheumatoid Arthritis Research and Therapies
- Protein Tyrosine Phosphatases
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Inflammatory Bowel Disease
- Assistive Technology in Communication and Mobility
- Vitamin C and Antioxidants Research
- Spondyloarthritis Studies and Treatments
- Cholesterol and Lipid Metabolism
- Hearing Impairment and Communication
- RNA regulation and disease
- Digestive system and related health
- Acute Kidney Injury Research
- Adenosine and Purinergic Signaling
- Eosinophilic Disorders and Syndromes
Universidade Federal de Pernambuco
2016-2024
Brazilian Biosciences National Laboratory
2020
Universidade Federal do Pará
2013
Universidade Federal Rural de Pernambuco
2012
Preterm birth (PTB) is featured by less than 37weeks of gestational age or fewer 259days since the first day from last menstrual period. Complications PTB are major cause neonatal deaths, several factors linked to increased risk including immunological and genetics. Vitamin D plays an important role in immune response modulation its action occurs through vitamin receptor (VDR), which recently has been described as overexpressed human placenta during pregnancy. Herein we assessed two single...
Rheumatoid arthritis (RA) is an autoimmune disease which can lead to progressive and functional disability. Literature data suggest that some inflammatory proteins are dysregulated in RA patients its genetic polymorphisms may contribute the aetiology pathogenesis of different ethnic groups. Polymorphisms IL1β, IL18, NFKB1 IFNG genes were studied populations with RA, but analysis indicated contradictory results. Thereby, we hypothesised these could have a combined effect on susceptibility...
Abstract Osteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite efforts to clarify relationship among and susceptibility develop OP, many associations need be further functionally validated. Besides, some limitations as choice stably expressed reference genes (RG) should overcome ensure quality reproducibility gene expression assays. To our knowledge, validation study for RG OP still missing. We compared levels, using polymerase...
Childhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early comorbidities. Several genetic, environmental, and immunological factors are known influence the of disease. MiRNAs have been already considered as potential actors involved development activity SLE. Thus, understanding behavior these regulators contribute clarify process affecting SLE patients. Among miRNAs, miR-125b-5p miR-9-5p targeting...
Aminobisphosphonates (NBPs) are the first-choice medication for osteoporosis (OP); NBP treatment aims at increasing bone mineral density (BMD) by inhibiting activity of farnesyl diphosphate synthase (FDPS) enzyme in osteoclasts. Despite its efficacy, inadequate response to drug and side effects have been reported. The A allele rs2297480 (A > C) SNP, found regulatory region FDPS gene, is associated with reduced gene transcription. This study evaluates variant association OP patients’...
The immune system plays a critical role in bone homeostasis and, consequently, the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces inflammasome and increases production pro-inflammatory cytokines, such as IL-1β IL-18. NLRP3 complex genes have been related with cellular animal models. Here, we performed an association study evaluating SNVs (single-nucleotide variants) pathway (NLRP3, CARD8, CASP1, IL-18, IL-1β) to assess whether variants these could be...
Introduction Systemic sclerosis (SSc) is a rare complex disease characterized by vascular damage, autoimmunity, and extensive skin internal organs fibrosis. Galectin-3 (Gal-3) encoded gene LGALS3 (Lectin, Galactoside-Binding, Soluble, 3; 14q22.3) it has been reported to play central role in self-tolerance, inflammation, fibrosis.Objective To investigate associations among single nucleotide polymorphisms (SNPs) serum levels Gal-3 SSc susceptibility their clinical features.Methods A...
To verify the relationship between sensory processing and changes in functions of stomatognathic system mouth breathing children, characterizing their comparing it with that nasal children.50 children (5 to 12 years) who were diagnosed 50 without signs symptoms or allergic rhinitis selected be part control group, matched for age sex. Oral underwent evaluation, through Sensory Processing Measure - home form, breathers, evaluation orofacial motricity Orofacial Myofunctional Evaluation score....
Summary Inflammatory bowel disease consists of multifactorial diseases whose common manifestation is inflammation the gastrointestinal tract and their pathogenesis remains unknown. This study aimed to analyse gene polymorphisms in Brazilian patients with inflammatory disease. A total 101 diagnosed were analysed for tumour necrosis factor‐alpha (‐308 G/A; rs1800629) interleukin‐10 (‐1082 rs1800896) polymorphisms. Genotyping was performed through polymerase chain reaction–sequence‐specific...
Clinical trials with sodium-glucose co-transporter 2 inhibitors (SGLT2i) have demonstrated to slow the progression of CKD by reducing hyperfiltration and proteinuria. However, SGLT2i shown anti-inflammatory properties that are not well explained so far. The aim this study is analyse gene expression IL-1β NLRP3 use dapagliflozin added standard care therapy (SoC), compared isolate SoC in inactive lupus nephritis (LN) patients.
Abstract Background and Aims Protein tyrosine kinases (PTKs) are enzymes responsible for the phosphorylation of residues in lymphocytes. In 2017, Mkaddem et al. suggested that unique PTK signatures peripheral leukocytes (PBMC) associated with lupus nephritis (LN) activity [1]. Lymphocytes express two important PTKs, Lyn Fyn, modulate inhibitory or activatory signals depending on ligand avidity status. SHP-1 536 (pSHP1-Y536) by activates signaling Fyn-dependent serine 591 (pSHP1-S591)...
Abstract Background and Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors slow the progression of chronic kidney disease (CKD). Lupus nephritis (LN) patients in remission may continue with residual proteinuria due to scars hyperfiltration. However, LN were excluded from main trials SGLT2 inhibitors. This trial aims assess effect safety dapagliflozin inactive proteinuria. Method For this cross-over randomized trial, we include adult class III, IV (±V) without active but >500...
Abstract Background and Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors slow the progression of chronic kidney disease (CKD) with without type diabetes. Lupus nephritis (LN) patients under immunosuppression were excluded from most important trials SGLT2 inhibitors. Thus, efficacy tolerance these drugs are unknown in such patients. The present trial will assess effect Dapagliflozin inactive Nephritis residual proteinuria. Method For this cross-over randomized trial, we include adult...
This study aimed to investigate the effects of hypoxia and serum deprivation on regulation fucosyltransferase-3 (FUT3) expression in breast cancer cells.FUT3 was evaluated T47D MCF7 cells. Transcriptional protein analysis performed under conditions after 6 24 hours; 48 hours, respectively.In cells, experimental induced a significant decrease FUT3 at both, transcriptional levels, while cells same increase expression.Regulation hypoxic may be involved acquisition advantages related apoptosis...
<h3>Background</h3> HLA-G may exert long-term immunotolerogenic effects through the generation of suppressor cells [reviewed in [1]]. Such features render an attractive candidate gene for susceptibility to immune mediated diseases. Indeed, our group has observed a positive association 3'UTR haplotype encompassing 14bp locus and +3142C/G (rs1063320) disease patients with systemic lupus erythematosus [2]. <h3>Objectives</h3> To investigate genetic influence two <i>HLA-G</i> polymorphisms – 14...