A5074979144- Bone health and osteoporosis research
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Bone health and treatments
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- NF-κB Signaling Pathways
- Blood groups and transfusion
- Molecular Biology Techniques and Applications
- Immunodeficiency and Autoimmune Disorders
- Folate and B Vitamins Research
- Whipple's Disease and Interleukins
- Traditional Chinese Medicine Studies
- Adrenal Hormones and Disorders
- MicroRNA in disease regulation
- Urticaria and Related Conditions
- Nuclear Receptors and Signaling
- Hemoglobinopathies and Related Disorders
- Parkinson's Disease Mechanisms and Treatments
- Vitamin C and Antioxidants Research
- Reproductive System and Pregnancy
- Erythrocyte Function and Pathophysiology
- Cell Adhesion Molecules Research
Universidade Federal de Pernambuco
2009-2024
Centro Universitário de Rio Preto
2024
Hospital das Clínicas da Universidade Federal de Pernambuco
2016-2022
Hospital Braga
2013
This is a report on how 1H NMR-based metabonomics was employed to discriminate osteopenia from osteoporosis in postmenopausal women, identifying the main metabolites associated separation between groups. The Assays were performed using seventy-eight samples, being twenty-eight healthy volunteers, twenty-six patients and twenty-four patients. PCA, LDA, PLS-DA OPLS-DA formalisms used. PCA discriminated samples volunteers diseased patient samples. Osteopenia-osteoporosis discrimination only...
Abstract We analyzed the possible association between human leukocyte antigen‐G ( HLA‐G ) genetic variants, supposed to regulate expression, and susceptibility develop rheumatoid arthritis RA as well its clinical manifestations. The 5′upstream regulatory region 5′URR 3′untranslated 3′UTR regions of gene were screened in 127 patients 128 controls: 10 5′ URR 3 3′ UTR polymorphisms two haplotypes associated with risk for development, while a polymorphism showed an degree disease activity. These...
Aminobisphosphonates (NBPs) are the first-choice medication for osteoporosis (OP); NBP treatment aims at increasing bone mineral density (BMD) by inhibiting activity of farnesyl diphosphate synthase (FDPS) enzyme in osteoclasts. Despite its efficacy, inadequate response to drug and side effects have been reported. The A allele rs2297480 (A > C) SNP, found regulatory region FDPS gene, is associated with reduced gene transcription. This study evaluates variant association OP patients’...
Abstract Osteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite efforts to clarify relationship among and susceptibility develop OP, many associations need be further functionally validated. Besides, some limitations as choice stably expressed reference genes (RG) should overcome ensure quality reproducibility gene expression assays. To our knowledge, validation study for RG OP still missing. We compared levels, using polymerase...
The aim of the present study was to evaluate impact SEMA4A genetic variants on expression sema4A protein and its relation autoimmunity development in Systemic Lupus Erythematosus Rheumatoid Arthritis patients. A total 541 SLE patients, 390 RA patients 607 healthy individuals were genotyped. We also assessed mRNA from whole blood cells vitro production resting activated T lymphocytes as well mature dendritic stratified according their genotypes for SLE/RA associated variants. Our results...
The immune system plays a critical role in bone homeostasis and, consequently, the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces inflammasome and increases production pro-inflammatory cytokines, such as IL-1β IL-18. NLRP3 complex genes have been related with cellular animal models. Here, we performed an association study evaluating SNVs (single-nucleotide variants) pathway (NLRP3, CARD8, CASP1, IL-18, IL-1β) to assess whether variants these could be...
Este artigo tem como objetivo revisar os aspectos descritos na literatura sobre o acometimento da macrovasculatura esclerose sistêmica e avaliar a ocorrência distribuição das alterações macrovasculares nos pacientes com através do eco-Doppler índice tornozelo-braço, além associação desses achados as características demográficas, forma clínica, tempo de evolução doença, fenômeno Raynaud (FR), digitais, ulcerações membros, reabsorção falange, amputação, bem fatores risco antecedentes doença...
OBJETIVO: Avaliar a ocorrência e distribuição das alterações macrovasculares em uma população com esclerose sistêmica (ES) por meio da ultra-sonografia Doppler (USG Doppler) do índice tornozelo-braço (ITB). Foi investigada associação destes achados as características demográficas clínicas dos pacientes, bem como fatores de risco antecedentes doença ateromatosa. MÉTODOS: Estudo prospectivo, tipo série casos, constituído 20 sendo 19 sexo feminino, idade média 46,30 anos. A forma clínica difusa...
We predicted miRNAs with regulatory impact on NFKB1 and TRAF6 gene expression selected the miR-194-5p, miR-124-3p, miR-9-5p, miR-340-5p their target genes for analyses CD14+ monocytes from rheumatoid arthritis (RA) patients healthy controls. Additionally, we evaluated influence of miRNA RA patients' cytokine levels. No difference was observed in or when compared to controls clinical parameters. However, found a significant between miR-194-5p miR-9-5p levels (FC=-2.31; p=0.031;...
No Brasil, um acidente de trabalho ocorre a cada 32 segundos, resultando em 673 mil incidentes registrados 2022. Nesse cenário, o enfermeiro do exerce uma função vital na saúde ocupacional, sendo responsável pela promoção, proteção e prevenção da dos trabalhadores. O presente estudo tem como objetivo analisar papel acidentes por meio revisão narrativa literatura. Foram consultadas as bases dados Google Acadêmico, Bdenf, Medline Pubmed, além eletrônicos Ministério Saúde. Os critérios inclusão...
Aims: Osteoporosis is a common disease that affects mostly women and has been associated with the immune system. The aims of this study were to evaluate serum levels inflammatory cytokines in postmenopausal osteoporosis investigate their relationship clinical laboratory parameters. Methods: This recruited patients (osteoporosis group) non-osteoporotic (control matched for age. All controls had bone mineral density measured diagnosis answered questionnaire. Blood samples collected cytokine...
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder that displays an important genetic background. Vitamin D3 (VD3 ) through its receptor (VDR) plays immunomodulatory role in misbalance, being capable of modulating immune responses. Genetic alterations VDR gene may contribute to altered risk SLE development and clinical manifestations. We investigated SNPs (single nucleotide polymorphisms) frequencies 128 patients 138 healthy controls (HC) mRNA differential expression...
Bone remodeling is marked by bone synthesis and absorption balance, any altered dynamic in this process leads to osteoporosis (OP). The interaction of hormonal, environmental genetic factors regulate metabolism. Since vitamin D displays a classic role metabolism regulation, acting through receptor (VDR), the variants within VDR were first ones associated with density remodelling. Therefore, we investigated whether three single nucleotide polymorphisms (SNPs) OP differential susceptibility...
A doença hemolítica perinatal é uma patologia que se inicia intraútero, podendo estender ao período neonatal, e desencadeada pela ação de anticorpos maternos sobre antígenos eritrocitários fetais. Exames imuno-hematológicos, laboratoriais moleculares realizados em épocas oportunas durante o pré-natal representam ferramentas essenciais para a identificação precoce gestações aloimunizadas, possibilitando monitoramento da evolução anemia fetal colaborando com adoção terapêutica adequada...