A5074825762- Synthesis and biological activity
- Peroxisome Proliferator-Activated Receptors
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Systemic Sclerosis and Related Diseases
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Psoriasis: Treatment and Pathogenesis
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Autoimmune and Inflammatory Disorders Research
- Click Chemistry and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Galectins and Cancer Biology
- Crystal structures of chemical compounds
Universidade Federal de Pernambuco
2015-2024
Universidade de Pernambuco
1992-2021
Hospital das Clínicas da Universidade Federal de Pernambuco
2012-2019
Instituto de Pesca
2019
Centro de Estudos e Sistemas Avançados do Recife
2018
Secretaria de Planejamento e Gestão
2017
Universidade Católica de Pernambuco
2014
Universidade Federal da Bahia
2010-2011
Universidade de São Paulo
2010
Universidade Federal de Ouro Preto
2002-2006
OBJECTIVES:Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years.Recently, novel mechanisms of action have proposed, thereby broadening the therapeutic perspective this medication.The purpose study was to evaluate immunomodulatory activity hydroxychloroquine T helper 17 (Th17) cytokines healthy individuals patients.METHODS: Eighteen female patients with (mean age 39.0¡12.9years) 13 51.5¡7.7 years) were...
The recent discovery that peroxisome proliferator-activated receptor γ (PPARγ) targeted anti-diabetic drugs function by inhibiting Cdk5-mediated phosphorylation of the has provided a new viewpoint to evaluate and perhaps develop improved insulin-sensitizing agents. Herein we report development novel thiazolidinedione retains similar efficacy as rosiglitazone in mice yet does not elicit weight gain or edema, common side effects associated with full PPARγ activation. Further characterization...
Eight new 5-arylidene-3-benzyl-thiazolidine-2,4-diones with halide groups on their benzyl rings were synthesized and assayed in vivo to investigate anti-inflammatory activities. These compounds showed considerable biological efficacy when compared rosiglitazone, a potent well-known agonist of PPARgamma, which was used as reference drug. This suggests that the substituted 5-arylidene 3-benzylidene play important roles properties this class compounds. Docking studies these indicated they...
Non-steroidal anti-inflammatory drugs (NSAIDs) represent a group of approximately 50 different medicines that are widely prescribed for the management inflammation and exhibit variable anti-inflammatory, anti-pyretic analgesic activities. Most NSAIDs also shared set adverse effects, particularly related to gastrointestinal complications; thus, development new treatment chronic pain continues be an issue high interest. Hydantoin indole derivatives reported possess various pharmacological...
Objective. To analyze the role of interleukin 22 (IL-22) in rheumatoid arthritis (RA). Methods. IL-22 serum levels were measured 83 patients with established RA under treatment disease-modifying antirheumatic drugs and 30 healthy controls matched for age sex. Patients assessed clinical laboratory variables. Correlations disease activity measures [Clinical Disease Activity Index (CDAI) Score 28 joints (DAS28)], serological markers, bone erosions, demographic factors assessed. Peripheral blood...
Introduction: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation NPRL3 inflammasome subsequently caspase-1, generating production active IL-1β IL-18. However, association between serum cytokines levels clinical manifestations not yet well understood. We evaluated profile proinflammatory (IL-1β, IL-6, IL-8, IL-17A, IL-18, IL-22, IL-23) described their relationship with laboratory data.Methodology: Thirty-nine male...
Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels pivotal correlate them with clinical parameters. Serum samples from 53 psoriasis patients 35 healthy volunteers, matched the proportion sex age ratios, were collected for ELISA cytokine detection. Area Severity Index (PASI) assessed at time sampling patients. Our findings demonstrate that IL-17A, IL-22, IL-6...
The purpose of this paper was to evaluate the levels IL-9 in patients with SLE and RA compared controls association clinical laboratory parameters. were assessed 117 patients, 67 24 healthy by ELISA. Clinical parameters recorded. serum significantly higher (4,77 ± 3,618 pg/mL) (12,26 25,235 than individuals (1,22 0,706 (p < 0,001). In there no statistically significant associations or correlations between SLEDAI other laboratorial parameters, exception disease time, which showed a negative...
Aim and Objective: Cancer has become one of the leading causes morbidity mortality worldwide. Limitations associated with existing agents increase need to develop more effective anticancer drugs improve therapeutic arsenal available. The aim this study was synthesize evaluate antiproliferative effects three new thiazacridine derivatives. Material Methods: Using a steps synthesis reaction, novel derivatives were obtained characterized:...
Schistosomiasis is considered the second most important tropical parasitic disease, with severe socioeconomic consequences for millions of people worldwide. Schistosoma mansoni, one causative agents human schistosomiasis, unable to synthesize purine nucleotides de novo, which makes enzymes salvage pathway targets antischistosomal drug development. In present work, we describe development a pharmacophore model ligands S. mansoni nucleoside phosphorylase (SmPNP) as well pharmacophore-based...
Thiazacridine and imidazacridine derivatives have shown promising results as tumors suppressors in some cancer cell lines. For a better understanding of the mechanism action these compounds, binding studies 5-acridin-9-ylmethylidene-3-amino-2-thioxo-thiazolidin-4-one, 5-acridin-9-ylmethylidene-2-thioxo-thiazolidin-4-one, 5-acridin-9-ylmethylidene-2-thioxo-imidazolidin-4-one 3-acridin-9-ylmethyl-thiazolidin-2,4-dione with calf thymus DNA (ctDNA) by electronic absorption fluorescence...
Interferon (IFN)-λ1 is a newly described cytokine, member of type III interferons family, which known for its antiviral, anti-proliferative and antitumor activity. Recent studies indicated that this cytokine has also immune-regulatory function, but role in the pathogenesis autoimmune diseases not established yet. We evaluated serum levels IFN-λ1 systemic sclerosis (SSc) patients healthy controls association with IFN-γ clinical manifestations.IFN-λ1 were measured by ELISA from 52 SSc 53...
Objective . To determine active TGF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>1 (aTGF-<mml:math id="M2"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants to understand their associations with clinical parameters systemic sclerosis (SSc) patients. Methods We evaluated serum samples from 56 SSc patients 24 healthy controls (HC). In...
Substitutions in thiophene structure give rise to new derivatives with different biological and pharmacological activities. The present study investigated the cytotoxicity activity of some breast cancer cells maintained two-dimensional (2D) or three-dimensional (3D) culture evaluated anticancer mechanism these compounds. Cytotoxicity assays were performed against untransformed cell MCF-7. Apoptosis analysis in-vitro migration assay also evaluate induction death. All reduced viability cells,...
The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types. present study aimed investigate expression gastric (GC) patient tissue and evaluate its clinical value. was evaluated by immunohistochemistry with 71 patients. staining observed cells of 53 (74.64%) patients, significant association histologic classification angiolymphatic invasion (p<0.05). Immunohistochemistry analysis also detected tumor-associated stroma...
Preliminary antifungal and cytotoxic evaluation of synthetic cycloalkyl[ b ]thiophene derivatives with PLS-DA analysis A series 2-[(arylidene)amino]-cycloalkyl[ ]thiophene-3-carbonitriles ( 2a-x ) was synthesized by incorporation substituted aromatic aldehydes in Gewald adducts 1a-c ). The title compounds were screened for their activity against Candida krusei Criptococcus neoformans antiproliferative a panel 3 human cancer cell lines (HT29, NCI H-292 HEP). For activity, the partial least...