A5088431714- Thyroid Disorders and Treatments
- Estrogen and related hormone effects
- Metabolism, Diabetes, and Cancer
- Phytochemistry Medicinal Plant Applications
- Phytochemicals and Antioxidant Activities
- Drug Transport and Resistance Mechanisms
- Hemophilia Treatment and Research
- Chemical synthesis and alkaloids
- Growth Hormone and Insulin-like Growth Factors
- Glycosylation and Glycoproteins Research
- Retinoids in leukemia and cellular processes
- Natural Antidiabetic Agents Studies
- Carbohydrate Chemistry and Synthesis
- Biochemical Analysis and Sensing Techniques
- Cancer-related Molecular Pathways
- Cholinesterase and Neurodegenerative Diseases
- melanin and skin pigmentation
- Peroxisome Proliferator-Activated Receptors
- Pesticide Exposure and Toxicity
- Monoclonal and Polyclonal Antibodies Research
- Folate and B Vitamins Research
- Natural product bioactivities and synthesis
- Nitric Oxide and Endothelin Effects
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
Universidade de Brasília
2013-2023
Otto-von-Guericke University Magdeburg
2004-2019
Leiden University Medical Center
2009
Institute of Immunology
2005
RMIT University
2005
Brazilian Synchrotron Light Laboratory
2004
Universidade de São Paulo
2004
University of California, San Francisco
2003
Atotech (United States)
2001
Institute of Bioorganic Chemistry
1998-2000
The recent discovery that peroxisome proliferator-activated receptor γ (PPARγ) targeted anti-diabetic drugs function by inhibiting Cdk5-mediated phosphorylation of the has provided a new viewpoint to evaluate and perhaps develop improved insulin-sensitizing agents. Herein we report development novel thiazolidinedione retains similar efficacy as rosiglitazone in mice yet does not elicit weight gain or edema, common side effects associated with full PPARγ activation. Further characterization...
The increased amount of melanin leads to skin disorders such as age spots, freckles, melasma and malignant melanoma. Tyrosinase is known be the key enzyme in production. Plants their extracts are inexpensive rich resources active compounds that can utilized inhibit tyrosinase well used for treatment dermatological associated with hyperpigmentation. Using vitro inhibitory activity assay, from 13 plant species Brazilian Cerrado were evaluated. results showed Pouteria torta Eugenia dysenterica...
Diabetes mellitus is the most common disease in world. One therapeutic approach for treating diabetes inhibition of α-amylase and α-glucosidase activities to reduce postprandial blood glucose levels. In vitro tests showed that several plant extracts from Brazilian cerrado species can inhibit activity α-glucosidase. The Eugenia dysenterica, Stryphnodendron adstringens, Pouteria caimito, ramiflora, torta strong inhibitory activity. P. aqueous exerted highest against (IC50 values 14.93, 13.6,...
Melanogenesis is a process responsible for melanin production, which stored in melanocytes containing tyrosinase. Inhibition of this enzyme target the cosmetics industry, since it controls undesirable skin conditions such as hyperpigmentation due to overproduction melanin. Species Morus genus are known beneficial uses offered different parts its plants, including tyrosinase inhibition. Thus, project aimed study inhibitory activity by extracts from nigra leaves well characterization...
The genus Pouteria belongs to the family Sapotaceae and can be widely found around World. These plants have been used as building material, food, because eatable fruits, well remedies in folk medicine. Some biological activities reported species of this such antioxidant, anti-inflammatory, antibacterial antifungal. However, real potential source new drugs or phytomedicines remains unknown. Therefore, a review so far known chemical composition is presented stimulate studies about already...
SKAP-HOM is a cytosolic adaptor protein representing specific substrate for the Src family tyrosine kinase Fyn. Previously, several groups have provided experimental evidence that (most likely in cooperation with ADAP) involved regulating leukocyte adhesion. To further assess physiological role of SKAP-HOM, we investigated immune system SKAP-HOM-deficient mice. Our data show T-cell responses towards variety stimuli are unaffected absence SKAP-HOM. Similarly, B-cell receptor (BCR)-mediated...
Thyroid hormone (triiodothyronine, T(3)) is known to activate transcription by binding heterodimers of thyroid receptors (TRs) and retinoid X (RXRs). RXR-TRs bind T(3) response elements (TREs) composed direct repeats the sequence AGGTCA spaced four nucleotides (DR-4). In other TREs, however, half-sites can be arranged as inverted palindromes (Pal). Here we show that TR homodimers monomers from representative TREs with alternate half-site placements. beta activates more efficiently than alpha...
Abstract Background Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level heart activities. Whereas metabolism increase lowering could be achieved by TRβ isoform activation, activation affects rates. Therefore, β-selective thyromimetics have been developed promising drug-candidates for treatment of obesity elevated level. GC-1 [3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)-phenoxy acetic acid] has ability to lower LDL with...
Abstract Background During transport‐associated adenosine triphosphate hydrolysis, P‐glycoprotein (Pgp) undergoes conformation transitions detected by UIC2, a functional anti‐Pgp monoclonal antibody. A newly developed UIC2 shift assay is based on increased reactivity in the presence of Pgp substrates. All peripheral blood leukocytes express low levels. The existing antibody‐based detection methods are limited their sensitivity and require additional techniques to simultaneously analyze...
Although taxels (in particular paclitaxel), cisplatin and fluorouracil (TPF) chemotherapy has been approved for use in the treatment of head neck squamous cell carcinoma (HNSCC), little is known with regard to cellular mechanisms this novel drug association. In order investigate reaction cells treatment, present study aimed examine cytotoxic effect TPF HNSCC lines combination irradiation, analyze its on cycle progression death, evaluate ability alter migration. An MTT assay was used...
Triterpenes from Pouteria gardneri (Mart. & Miq.) Baehni extractsCintia Alves de Matos Silva, Ricardo Oliveira e Melo, Inês Sabioni Resck, Dâmaris Silveira
Hippeastrum goianum (Ravenna) Meerow, Amaryllidaceae, is an endemic species from the Cerrado, Brazil; there are only few studies about its chemistry or biological activity. This study aimed to investigate occurrence of lycorine in extracts vitro H. plantlets, as well evaluate a possible inhibition acetylcholinesterase. The ethanol extract plantlets produced by seed germination and micropropagation bulblets was obtained seedlings germination, while micropropagtion subculture those seedlings....