A5041422227- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Proteoglycans and glycosaminoglycans research
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
Universidade Federal de Pernambuco
2019-2022
The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types. present study aimed investigate expression gastric (GC) patient tissue and evaluate its clinical value. was evaluated by immunohistochemistry with 71 patients. staining observed cells of 53 (74.64%) patients, significant association histologic classification angiolymphatic invasion (p<0.05). Immunohistochemistry analysis also detected tumor-associated stroma...
The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal neoplastic cells. This study aimed at investigating the differential tissue expression of GALE its possible association with clinical-pathological parameters outcome gastric adenocarcinoma patients. Seventy-one patients were evaluated relation to by immunohistochemistry. Our results showed that 48 (67.6%) positive 23 (32.4%) negative. Positive staining was present...
Gastric cancer (GC) is one of the leading causes cancer-related deaths worldwide. Despite progress in last decades, there are still no reliable biomarkers for diagnosis and prognosis GC. Aberrant sialylation a widespread critical event development Neuraminidases (Neu) sialyltransferases (STs) regulate ablation addition sialic acid during glycoconjugates biosynthesis, they considerable source various cancers. This study retrospectively characterized Neu3 ST3Gal3 expression by...