A5020031069- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Systemic Lupus Erythematosus Research
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- ATP Synthase and ATPases Research
- Chronic Lymphocytic Leukemia Research
- PARP inhibition in cancer therapy
- Heat shock proteins research
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Cell death mechanisms and regulation
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- Phytochemistry Medicinal Plant Applications
- Antioxidant Activity and Oxidative Stress
Universidade Federal de Pernambuco
2013-2025
Universidade Federal do Oeste do Pará
2018
Background: Prostate and pancreatic cancers pose significant global health challenges. This study explored the potential of compound 5b, a novel phthalimido-1,3-thiazole derivative, as an anticancer agent against these malignancies. Methods: In vitro, 5b exhibited potent cytotoxic activity both prostate (DU-145 PC-3) (Panc-1 Mia Paca-2) cancer cell lines. Notably, it significantly reduced colony formation in PC-3 cells, potentially hindering tumor growth. Furthermore, treatment with...
Substitutions in thiophene structure give rise to new derivatives with different biological and pharmacological activities. The present study investigated the cytotoxicity activity of some breast cancer cells maintained two-dimensional (2D) or three-dimensional (3D) culture evaluated anticancer mechanism these compounds. Cytotoxicity assays were performed against untransformed cell MCF-7. Apoptosis analysis in-vitro migration assay also evaluate induction death. All reduced viability cells,...
Aim and Objective: In the last decades, cancer has become a major problem in public health all around globe. Chimeric chemical structures have been established as an important trend on medicinal chemistry years. Thiazacridines are hybrid molecules composed of thiazolidine acridine nucleus, both pharmacophores that act biological targets for cancer. By fact it is serious disease, seven new 3-acridin-9-ylmethyl-thiazolidine-2,4-dione derivatives were synthesized, characterized, analyzed by...
Thiophene derivatives have been widely studied as promising options for the treatment of solid tumors. Previous studies shown that thiophene antileishmanial activity and cytotoxic against breast, colon, ovarian cancer cells.In our study, we evaluated anticancer activities three aminothiophene derivatives: SB-44, SB-83, SB-200, in prostate cervical adenocarcinoma cells. Several vitro methods were performed, including cytotoxicity, clonogenic migration, mutagenic, cleaved Poly (ADP-ribose)...
Thiophenes are heterocyclic compounds containing a five-membered ring with sulphur as the heteroatom. This class of substances has been shown to have several biological activities, including specific anti-proliferative effects against some cancer cell lines. The aim present study was evaluate in vitro possible cytotoxic, genotoxic, and mutagenic properties synthetic thiophenes using lines derived from human solid tumours. Different methodologies were employed assess cytotoxic here named...
Introduction: Ethnobotanical studies report that Myrcia guianensis (Myrtaceae), belonging to a group of plants known as pedrá-ume-caá or insulin plant, is used tea treat various diseases, including diabetes, metabolic disorder leads the constant production free radicals. The objective this work was determine antioxidant capacity and cytotoxicity AEMg. Methods: content phenolic compounds in AEMg determined by colorimetric assays. In vitro tests AEMg, sequestration DPPH radicals, β-carotene...
Abstract The combination of pharmacophoric nuclei with different targets has been a strategy for the development new drugs aimed at improving cancer treatment. A series ten novel phthalimido-thiazolidine-2-4-dione derivatives were synthesized by two synthetic routes. compounds tested and evaluated in vitro , through antineoplastic activities against cells. Cell cycle analyzes clonogenic assay also performed. In addition to these tests, silico predictions FT-12 compound (9j) exhibited...
Cancer is one of the most important barriers to increasing life expectancy in all countries 21st century. Investigations new anti-cancer drugs with low side effects are an urgent demand for medicinal chemists. Considering known antitumor and immunomodulatory activity thiazoles, this work presents synthesis antineoplastic thiazoles.The 22 compounds (2a-v) were synthesized from different thiosemicarbazones 2-bromoacetophenone. The evaluated on: MOLT-4, HL-60, HL-60/MX1, MM1S, SKMEL-28, DU145,...
Abstract The combination of pharmacophoric nuclei with different targets has been a strategy for the development new drugs aimed at improving cancer treatment. A series ten novel phthalimido-thiazolidine-2-4-dione derivatives were synthesized by two synthetic routes. compounds tested and evaluated in vitro , through antineoplastic activities against cells. Cell cycle analyzes clonogenic assay also performed. In addition to these tests, silico predictions FT-12 compound (9j) exhibited...