A5100661234- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Agricultural and Food Sciences
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Carcinogens and Genotoxicity Assessment
- Soil Management and Crop Yield
- Synthesis of Organic Compounds
- Synthesis of heterocyclic compounds
- Rural Development and Agriculture
- Yeasts and Rust Fungi Studies
- Pressure Ulcer Prevention and Management
- Occupational Health and Burnout
- Occupational Health and Safety Research
- Polysaccharides Composition and Applications
- Proteoglycans and glycosaminoglycans research
- Research on Leishmaniasis Studies
- Business and Management Studies
- Helminth infection and control
- Pharmacogenetics and Drug Metabolism
- Chemotherapy-induced organ toxicity mitigation
- Rural and Ethnic Education
- Healthcare during COVID-19 Pandemic
Centro Universitário Assunção
2024
Federal University of São João del-Rei
2014-2023
Universidade Federal Rural de Pernambuco
2012
Institute for Biotechnology and Bioengineering
2009
University of Minho
2009
Abstract Gellan gum is a polysaccharide manufactured by microbial fermentation of the Sphingomonas paucimobilis microorganism, being commonly used in food and pharmaceutical industry. It can be dissolved water, when heated mixed with mono or divalent cations, forms gel upon lowering temperature under mild conditions. In this work, gellan hydrogels were analyzed as cells supports context cartilage regeneration. hydrogel discs characterized terms mechanical structural properties....
Porto Velho é capital do estado de Rondônia, e no que se refere a Educação campo, possui uma trajetória marcada por transformações sociais, políticas econômicas refletem os desafios, avanços as perspectivas ao longo dos anos. Compreender esse contexto histórico essencial para análise crítica das públicas voltadas educação camponesa. O presente artigo objetiva analisar desafios âmbito da camponesa município Velho, além compreender organização instituições educacionais localizadas nessas...
Cancer continues to be one of the most important health problems worldwide, and identification novel drugs treatments address this disease is urgent. During recent years, marine organisms have proven a promising source new compounds with action against tumoral cell lines. Here, we describe synthesis anticancer activity eight 3-alkylpyridine alkaloid (3-APA) analogs in four steps good yields. The key step for these Williamson etherification under phase-transfer conditions. We investigated...
In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both schistosomulum (somule) and adult forms Schistosoma mansoni. Compounds 8 12 showed significant activity somules at low micromolar concentrations, but none active adults. The SAR demonstrated that compounds most parasite were mutagenic to human cell line RKO-AS45-1 only concentrations 10- 40-fold higher than worm-killing dose. Given their electrophilicity, also...
A presença de plantas invasoras interfere negativamente no desempenho das cultivadas, competindo por espaço, luz, água e nutrientes. Nesse contexto, o controle do mato é essencial para que as atinjam altas produtividades qualidade nutricional adequada. Assim, objetivou-se avaliar os efeitos manejo mediante a capina roçada seus sobre cobertura fertilidade um Latossolo Vermelho. O experimento foi conduzido campo, delineamento blocos casualizados com quatro repetições. Adotou-se esquema...
Objetivo: Buscar na literatura evidências quanto ao conhecimento dos enfermeiros no tratamento de feridas Atenção Primária à Saúde. Métodos: Trata-se uma revisão integrativa da literatura, realizada nas bases dados eletrônicas MEDLINE via Biblioteca Virtual em Saúde, BDEFN e LILACS, por meio associação descritores, tendo como critérios inclusão artigos disponíveis íntegra, idioma português, entre os anos 2019 a 2023. Foram excluídos editoriais, cartas editor, resenhas, teses, dissertações...
Este artigo tem como objetivo abordar a questão da gestão de riscos na administração pública brasileira, com base Instrução Normativa Conjunta MPOG/CGU nº 01 2016, que formalizou obrigatoriedade implementação processos riscos. O estudo investiga e analisa produção acadêmica sobre o tema aplicado ao setor público, foco nas instituições públicas ensino superior. A metodologia utilizada contempla pesquisa exploratória natureza qualitativa, partir revisão bibliográfica. coleta dados abrangeu...
Thiophene derivatives have been widely studied as promising options for the treatment of solid tumors. Previous studies shown that thiophene antileishmanial activity and cytotoxic against breast, colon, ovarian cancer cells.In our study, we evaluated anticancer activities three aminothiophene derivatives: SB-44, SB-83, SB-200, in prostate cervical adenocarcinoma cells. Several vitro methods were performed, including cytotoxicity, clonogenic migration, mutagenic, cleaved Poly (ADP-ribose)...
Thiophenes are heterocyclic compounds containing a five-membered ring with sulphur as the heteroatom. This class of substances has been shown to have several biological activities, including specific anti-proliferative effects against some cancer cell lines. The aim present study was evaluate in vitro possible cytotoxic, genotoxic, and mutagenic properties synthetic thiophenes using lines derived from human solid tumours. Different methodologies were employed assess cytotoxic here named...
The purpose of this study was to evaluate the effects gamma radiation in vitro on major phytopathological agents mango cultivar Tommy Atkins. morphophysiological parameters evaluated were mycelial growth, sporulation and aspects colonies (color topographical aspect) fungi Colletotrichum gloeosporioides, Alternaria alternata Fusicoccum parvum after exposure Petri dishes application 1.0 kGy with Co60 source. dose significant enough inhibit growth C. gloeosporioides A. alternata, but it...
Although the presence of nitro groups in chemicals can be recognized as structural alerts for mutagenicity and carcinogenicity, nitroaromatic compounds have attracted considerable interest a class agents that serve source potential new anticancer agents. In present study, vitro cytotoxicity, genotoxicity, three synthetic ortho-nitrobenzyl derivatives (named ON-1, ON-2 ON-3) were evaluated by employing human breast ovarian cancer cell lines. A series biological assays was carried out with...