A5021607134- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Enterobacteriaceae and Cronobacter Research
- Aquaculture disease management and microbiota
- Plant Pathogenic Bacteria Studies
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Microbial Metabolism and Applications
- Listeria monocytogenes in Food Safety
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Identification and Quantification in Food
Universidade de São Paulo
2016-2024
Universidade de Ribeirão Preto
2022-2024
SUPERA Park of Innovation and Technology of Ribeirão Preto
2023
Hospital Universitário da Universidade de São Paulo
2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or asymptomatic COVID-19 in most cases, but some patients develop an excessive inflammatory process that can be fatal. As the NLRP3 inflammasome and additional inflammasomes are implicated disease aggravation, drug repositioning to target emerges as a strategy treat COVID-19. Here, we performed high-throughput screening using 2560 small-molecule compound library identified FDA-approved drugs function pan-inflammasome...
Whole genome sequencing (WGS) has been used as a powerful technology for molecular epidemiology, surveillance, identification of species and serotype, the sources outbreaks, among other purposes. In Brazil, there is relatively few epidemiological data on Salmonella. this study, 90 Salmonella Typhimurium strains had their sequenced to uncover diversity isolated from humans food, between 1983 2013, different geographic regions in Brazil based single nucleotide polymorphism (SNP) analysis. A...
Salmonella enterica subsp. serovar Typhimurium (S. Typhimurium) causes gastroenteritis in many countries. However, Brazil there are few studies that have conducted a virulence characterization of this serovar. The aim study was to evaluate the potential S. strains isolated Brazil. Forty from humans (n = 20) and food were studied regarding their invasion survival human epithelial cells (Caco-2) macrophages (U937). Their determined using Galleria mellonella larvae model combined with analysis...
Invasive non-typhoidal Salmonella (iNTS) from the clonal type ST313 (S. Typhimurium ST313) is primary cause of invasive salmonellosis in Africa. Recently, Brazil, iNTS strains have been isolated different sources, but there a lack understanding mechanisms behind how these gut bacteria can break barrier and reach patient's bloodstream. Here, we compare 13 S. ST313, previously unreported isolates, human blood cultures, investigating aspects virulence resistance. Initially, RNAseq analyses...
Abstract Background Salmonella enterica subsp. serovar Typhimurium ( S . Typhimurium) is an important zoonotic agent worldwide. The aim of this work was to compare genetically 117 S. isolated from different sources over 30 years in Brazil using genomics strategies. Results majority the strains studied were grouped into a single cluster (≅ 90%) by core genome multilocus sequence typing and 77%) copy marker genes. phylogenetic analysis based on nucleotide polymorphism (SNP) most humans 93%),...
Shigella sonnei is an important causative agent of bacillary dysentery worldwide that has recently emerged in developing countries. However, there are few studies have characterized strains ofS. isolated Brazil. The aims this study were to assess the presence 12 virulence genes, antimicrobial resistance profile against 16 drugs and genotypic diversity S. country. Seventy-two from human diarrhoeic faeces São Paulo State, Brazil 1983-2014 studied. All contained ipaH, iuc sigA genes. ipaBCD...
Staphylococcus aureus is one of the main pathogens associated with foodborne outbreaks in Brazil and food handlers can carry toxigenic resistant S. strains. The aims this study were to verify frequency virulence genes, identify agr groups determine antimicrobial resistance profile strains isolated from pilot kitchens located São Paulo, Brazil. A total 74 genus detected 50% identified as species aureus. enterotoxin genes detection, tst luk-PV typing, mecA ccr complex detection SCCmec typing...
Introduction. Salmonella 1,4, [5],12:i:- strains with different antimicrobial resistance profiles have been associated foodborne disease outbreaks in several countries. In Brazil, S . was identified as one of the most prevalent serovars São Paulo State during 2004–2020. Gap Statement. However, few studies characterized this serovar Brazil. Aim. This study aimed to determine isolated from sources Southeast Brazil and compare their genetic diversity. Methodology. We analysed 113 humans ( n...
Background Salmonella enterica serovar Infantis ( Infantis) is a zoonotic, ubiquitous and foodborne pathogen of worldwide distribution. Despite Brazil’s relevance as major meat exporter, few studies were conducted to characterize strains this by genomic analyses in country. Therefore, study aimed assess the diversity 80 isolated from veterinary, food human sources Brazil between 2013 2018 comparative analyses. Additional genomes non-Brazilian countries n = 18) included for comparison...
ABSTRACT Salmonellosis is a disease with high incidence worldwide, and Salmonella enterica subsp. serovar Typhimurium one of the most clinically important serovars. We report here draft genome sequences 20 S. strains isolated from swine in Santa Catarina, Brazil. These genomes will improve our understanding
Abstract Invasive non-typhoidal Salmonella (iNTS) from the clonal type ST313 ( S . Typhimurium ST313) is major cause of invasive salmonellosis disease in Africa. Recently Brazil, iNTS strains have been isolated different sources, but there a lack understanding mechanisms behind how these gut bacteria are able to break barrier and reach patient’s bloodstream. Herein, we compared 13 genomes human-blood cultures investigating aspects virulence resistance mechanisms. RNAseq analyses were also...
Shigella sonnei, which has generally been associated with dysentery in developed countries, recently emerging developing countries. Specifically, Brazil few published studies have that molecularly characterized this species. The aims of study were to analyze the efficacy typing using multiple-locus variable-number tandem-repeat analysis (MLVA), phylogeny by multi-locus sequence (MLST) and assess presence some beta-lactam resistance genes S. sonnei strains isolated from human diarrhoeic...
Abstract Background: Salmonella enterica subsp. serovar Typhimurium ( S . Typhimurium) is an important zoonotic agent worldwide. In Brazil, there are few published studies that have characterized the possible differences of strains isolated from humans, foods and animal by whole genome sequencing (WGS). The aim this work was to compare genetically 117 S. isolates different sources 30 years (1983 2013) in Brazil using genomics strategies, including: phylogenetic analysis; orthologous protein...
Abstract Staphylococcus aureus is an important pathogen associated with various infections, including foodborne outbreaks worldwide. Due to possible contamination during food preparation by handlers, the presence of this species in kitchens environmental a risk global health, mainly S. biofilm-producing. Moreover, there are few reports evaluation biofilm production obtained from handlers Brazil. The study aimed characterize phenotypically and genotypically ica -dependent -independent genes...