A5002295612- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Adipose Tissue and Metabolism
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Multiple Sclerosis Research Studies
- Intensive Care Unit Cognitive Disorders
- Genetic Syndromes and Imprinting
- Hereditary Neurological Disorders
- Stoma care and complications
- Sepsis Diagnosis and Treatment
- Breastfeeding Practices and Influences
- Pathogenesis and Treatment of Hiccups
- Optical Imaging and Spectroscopy Techniques
- Cardiovascular Disease and Adiposity
- CNS Lymphoma Diagnosis and Treatment
- Thermodynamic properties of mixtures
- Cancer-related cognitive impairment studies
Universidade Estadual de Campinas (UNICAMP)
2017-2025
Brazilian Institute of Neuroscience and Neurotechnology
2021-2024
Hospital de Clínicas da Unicamp
2023
Universidade de Fortaleza
2017
Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term dysfunction (recently characterized as part of "long COVID-19" syndrome) has been frequently observed after mild infection. We show the spectrum cerebral impact acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety...
Abstract Although some studies have shown neuroimaging and neuropsychological alterations in post-COVID-19 patients, fewer combined neuropsychology evaluations of individuals who presented a mild acute infection. Here we investigated cognitive dysfunction brain changes group mildly infected individuals. We conducted cross-sectional study 97 consecutive subjects (median age 41 years) without current or history psychiatric symptoms (including anxiety depression) after infection, with median 79...
Abstract Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, the long-term dysfunction has been frequently observed after mild infection. Here we show spectrum of cerebral impact SARS-CoV-2 infection ranging from alterations in mildly infected individuals (orbitofrontal cortical atrophy, neurocognitive impairment, excessive fatigue and anxiety symptoms) to acute damage confirmed brain tissue samples extracted orbitofrontal...
Abstract COVID-19 patients may exhibit neuropsychiatric and neurological symptoms. We found that anxiety cognitive impairment are manifested by 28-56% of SARS-CoV-2-infected individuals with mild respiratory symptoms associated altered cerebral cortical thickness. Using an independent cohort, we histopathological signs brain damage in 25% who died COVID-19. All the affected tissues exhibited foci SARS-CoV-2 infection replication, particularly astrocytes. Infection neural stem cell-derived...
ABSTRACT Background Spinal cord has been considered the main target of damage in hereditary spastic paraplegias (HSPs), but mounting evidence indicates that brain is also affected. Despite this, little known about signature HSPs, particular regarding stratification for specific genetic subtypes. Objective We aimed to characterize cerebral and cerebellar five HSP subtypes (9 SPG3A, 27 SPG4, 10 SPG7, 9 SPG8, 29 SPG11) uncover clinical gene expression correlates. Methods obtained...
ABSTRACT Although post-acute cognitive dysfunction and neuroimaging abnormalities have been reported after hospital discharge in patients recovered from COVID-19, little is known about persistent, long-term alterations who did not require hospitalization. Therefore, we conducted a cross-sectional study of 87 consecutive, non-hospitalized individuals, with median 54 days the laboratory confirmation COVID-19. We performed structured interviews, neurological examination, 3T-MRI scans. The MRI...
Abstract Introduction/Aims Carriers of DMD pathogenic variants may become symptomatic and develop muscle‐related manifestations. Despite that, few studies have attempted to characterize changes in the muscles these carriers using imaging tools, particularly muscle ultrasound (MUS). The aim this study was compare lower limb MUS findings (cDMD) vs healthy controls. Methods Twenty‐eight women (15 cDMD 13 controls) underwent clinical evaluation MUS. We collected information about symptoms...
Spinal cord (SC) damage is a hallmark in Friedreich's ataxia (FRDA). Neuroimaging has been able to capture some SC macroscopic changes, but no study evaluated microstructural white matter (WM) vivo.We designed cross-sectional evaluate integrity WM tracts of FRDA patients using diffusion tensor imaging (DTI) with an automated analysis pipeline.Thirty and 30 matched healthy controls underwent 3 Tesla (T) magnetic resonance (MRI). We obtained cervical T2 diffusion-weighted (DWI) acquisitions....
Abstract Background RFC1‐related disorder is a novel heredodegenerative condition with broad phenotypic spectrum. Its neuropathological bases are not yet fully understood, particularly regarding the pattern, extent, and clinical relevance of spinal cord (SC) damage. Objectives The objectives were to determine SC structural signature in vivo identify potential correlates for these imaging abnormalities. Methods We enrolled 17 subjects biallelic RFC1 (AAGGG)n expansions 11 age‐ sex‐matched...
Background The expression of serine protease granzyme-B (GzmB) by circulating CD8 + T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders (NMOSD). In parallel, venous thromboembolism (VTE) reported mainly NMOSD exhibiting transverse myelitis. Case presentation Here, we describe an Aquaporin-4 positive (AQP4-positive) patient who showed short myelitis (SM) experienced fatal...
<h3>Objective:</h3> Evaluate the effect of COVID-19 presumed viral strains on different cognitive domains. <h3>Background:</h3> Cognitive dysfunction (CD) is a frequent and debilitating symptom long-COVID syndrome with negative impact survivors' productivity quality life. It unknown whether there are strain-specific effects cognition. <h3>Design/Methods:</h3> We used Fiocruz database (http://www.genomahcov.fiocruz.br) to separate 452 subjects (15 years education; 88 days after diagnosis)...
<h3>Objective:</h3> To compare patterns of grey matter atrophy (GMA) in post-COVID syndrome according to four different strains SARS-CoV-2 <h3>Background:</h3> The neuropsychiatric symptoms the are frequent and debilitating represents a major public health concern. Unfortunately, neither physiopathology nor underlying cerebral alterations understood. <h3>Design/Methods:</h3> We analyzed 3T T1 MRI 300 subjects (non-hospitalized, median age 40 years, 209 women, an average 150 days from...
Abstract Background: Little is known about the underpinning mechanisms of neurological dysfunction in post-COVID syndrome. Methods: We conducted a cross-sectional study 87 consecutive subjects after mild infection, with median 54 days diagnosis COVID-19. performed structured interviews, examinations, 3T-MRI scans, and neuropsychological assessments. The MRI included white matter investigation diffusion tensor images (DTI) functional connectivity resting-state (RS-fMRI). Results: Subjects...
Introduction: Duchenne muscular dystrophy (DMD) is the most frequent muscle in children. It an X-linked condition caused by loss of function variants DMD gene. During disease course, affected patients lose lean body mass, become severely motor disabled and are often treated with long term steroids. All these factors pose them at increased risk for developing metabolic syndrome (MS), even as Surprisingly, there few studies addressing this aspect cohorts, particularly Brazil. Objectives: To...
<h3>Objective:</h3> To assess depression/anxiety symptoms, fatigue and daytime sleepiness in individuals previously affected by the COVID-19 infection. <h3>Background:</h3> Neuropsychiatric symptoms may persist after <h3>Design/Methods:</h3> We included 1183 cases of post-Covid infection (79% women; median age 41 [12–77]) who answered an interview our online survey (median interval 191 days [50–503] infection). used Hamilton Anxiety Depression Scale to evaluate anxiety (HADS-A) depression...
Illiteracy is a risk factor for the occurrence of dementia and associated with lower cognitive reserve, but patients higher educational level tend to have faster decline. One hundred fort three Alzheimer Disease an outpatient clinic disorders in northeastern region Brazil were followed retrospectively. All follow-up at least 1 year. Patients who presented stability or increase MMSE score between first last visit considered good responders. Student T test, Mann-Whitney test Chi-square used...
BACKGROUNDLewis-Sumner syndrome is a multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) characterized by asymmetric involvement, with weakness of distal predominance, evolution from months to years, categorized as variant chronic inflammatory polyneuropathy (CIDP).Among the 19 neuropsychiatric manifestations systemic lupus erythematosus (SLE) classified American College Rheumatology, 7 are peripheral manifestations; however, CIDP its variants not considered. CASE...