A5072583774- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Macrophage Migration Inhibitory Factor
- Gout, Hyperuricemia, Uric Acid
- Endometriosis Research and Treatment
- Ion Channels and Receptors
- Fatty Acid Research and Health
- Toxin Mechanisms and Immunotoxins
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Healthcare and Venom Research
- Exercise and Physiological Responses
- IL-33, ST2, and ILC Pathways
- Uterine Myomas and Treatments
- Research on Leishmaniasis Studies
- Natural product bioactivities and synthesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Herbal Medicine Research Studies
- Glutathione Transferases and Polymorphisms
- Venomous Animal Envenomation and Studies
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Mosquito-borne diseases and control
- Neuropeptides and Animal Physiology
Universidade Estadual de Londrina
2014-2024
Washington University in St. Louis
2024
Harvard University
2023-2024
Boston Children's Hospital
2023-2024
Background and Purpose Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain. Current therapies are often ineffective in reducing gout‐related Resolvin D1 (RvD1) a specialized pro‐resolving lipid mediator with anti‐inflammatory analgesic proprieties. In this study, we evaluated the effects mechanisms of action RvD1 experimental mouse model gouty arthritis, aim that was not pursued previously literature. Experimental...
Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into groundbreaking paradigm neuroimmunology discuss recent scientific evidence impact on responses against wide range pathogens diseases, encompassing microbial infections cancers. These valuable insights enhance our understanding interactions between systems, also pave way...
Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up to 15% of women transgender men. Current treatments are ineffective for substantial proportion patients, underscoring the need additional therapies with long-term benefits. Nociceptors release neuropeptides, such as calcitonin gene–related peptide (CGRP), which known shape immunity through neuroimmune communication. Given comorbidity between endometriosis migraine integral role immune cells...
Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients. Trans-Chalcone (1,3-diphenyl-2-propen-1-one) a flavonoid precursor presenting biological activities such as anti-inflammatory antioxidant proprieties. Thus, aim this work was evaluate protective effects trans-Chalcone experimental gout mice. Mice were treated with (3, 10, or 30mg/kg, per oral) vehicle (Tween 80 20%...
Abstract Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals the joints. 15deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ ) natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed evaluate effect mechanisms action 15d-PGJ nanocapsules (NC) model GA mice, since reduction 33-fold dose has been reported. Mice were treated -loaded NC, inert free (without NC), or NC+ GW9662, inhibitor. We show that NC...
Hesperidin is derived from citrus fruits among other plants. was methylated to increase its solubility, generating hesperidin methyl chalcone (HMC), an emerging flavonoid that possess anti-inflammatory and antioxidant properties. The nuclear factor erythroid 2-related 2 (Nrf2) a powerful regulator of cellular resistance oxidant products. Previous data evidenced HMC can activate Nrf2 signaling, providing protection against diverse pathological conditions. However, effects on kidney damage...
Chikungunya virus is an arthropod-borne infectious agent that causes fever disease. About 90% of the infected patients experience intense polyarthralgia, affecting mainly extremities but also large joints such as knees. Chronic disease symptoms persist for months, even after clearance from blood. Envelope proteins stimulate immune response against virus, becoming important therapeutic target. We inactivated (iCHIKV) and produced recombinant E2 (rE2) protein three different types anti-rE2...
Unaccustomed exercise involving eccentric contractions, high intensity, or long duration are recognized to induce delayed-onset muscle soreness (DOMS). Myocyte damage and inflammation in affected peripheral tissues contribute sensitize nociceptors leading pain. However, despite the essential role of spinal cord regulation pain, neuroinflammatory mechanisms intense swimming-induced DOMS remain be investigated. We hypothesized that neuroinflammation contributes DOMS. C57BL/6 mice swam for 2 h...
Background: Gout is the most common inflammatory arthritis worldwide. It a painful disease induced by deposition of monosodium urate (MSU) crystals in joints and peri-articular tissues. Sesquiterpene lactones (SLs) are secondary metabolite biosynthesized mainly species from family Asteraceae. has been demonstrated that SLs present anti-inflammatory, analgesic, antitumoral, antiparasitic, antimicrobial activities. In this study, we aimed at evaluating efficacy SL budlein A model acute gout...
Clinically active drugs for the treatment of acute pain have their prescription limited due to significant side effects they induce. An increase in reactive oxygen species (ROS) has been linked several conditions, including inflammation and processing. Therefore, new or repurposed with ability reducing ROS-triggered responses are promising candidates analgesic drugs. Vinpocetine is a clinically used nootropic drug antioxidant, anti-inflammatory, properties. However, vinpocetine not...
Abstract The perineuronal net (PNN) is a well‐described highly specialized extracellular matrix structure found in the central nervous system. Thus far, no reports of its presence or connection to pathological processes have been described peripheral Our study demonstrates PNN spinal afferent innervation distal colon mice and characterizes structural morphological alterations induced an ulcerative colitis (UC) model. C57Bl/6 were given 3% dextran sulfate sodium (DSS) induce acute chronic UC....
The cellular and molecular pathophysiological mecha\nisms of pain processing in neglected parasitic infections such as leishmaniasis remain unknown. present study evaluated the participation spinal cord glial cells pathophysiology induced by Leishmania amazonensis infection BALB/c mice. Mice received intra-plantar (i.pl.) injection L. (1 × 105) hyperalgesia, paw edema were bilaterally for 40 days. levels TNF-α IL-1β, MPO activity, histopathology assessed on 40th day. ATF3 mRNA expression was...
Monosodium urate crystals (MSU) deposition induces articular inflammation known as gout. This disease is characterized by intense and pain mechanisms involving the activation of transcription factor NFκB inflammasome resulting in production cytokines oxidative stress. Despite evidence that MSU iNOS expression, there no on effect nitric oxide (NO) donors Thus, present study evaluated ruthenium complex donor NO {[Ru(bpy)2(NO)SO3](PF6)} (complex I) gout arthritis. Complex I inhibited a...
Lipoxin A4 (LXA
Despite the wide variety of Covid-19 symptoms, pain and related mechanisms underlying unsettled nociceptive status are still under-prioritized. Understanding complex network Covid-19-related may result in new lines study. It is unknown whether patient's immunological background influences acute phase Covid-19, including musculoskeletal pain. Thus, we evaluated blood levels selected molecules that upregulated SARS-CoV-2 infection analyzed a possible correlation with during Covid-19.A cohort...
Endometriosis is a chronic inflammatory disease that affects ∼10 % of women. A significant fraction patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting pathology involves neurotrophic activity angiogenesis.