Abstract Aim This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp . lactis ( B. ) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Materials Methods Forty‐one periodontitis were recruited monitored clinically, immunologically, microbiologically at baseline (before SRP) 30 90 days after SRP. All randomly assigned a Test (SRP + Probiotic, n = 20) or Control...

The literature suggests that an alteration in glucose metabolism occurs as a result of antibacterial periodontal therapy. objective this study was to monitor the effect non-surgical therapy on glycemic control patients with type 2 diabetes mellitus (DM).Thirty DM subjects periodontitis were randomly divided into two groups. Group 1 (G1), 15 subjects, received one-stage full-mouth scaling and root planing (FMSRP) plus amoxicillin/clavulanic acid 875 mg; group (G2), patients, only FMSRP. At...

Background: The treatment of aggressive periodontitis has always presented a challenge for clinicians, but there are no established protocols and guidelines the efficient control disease. Methods: Ten patients with clinical diagnosis were treated in split‐mouth design study to either photodynamic therapy (PDT) using laser source wavelength 690 nm associated phenothiazine photosensitizer or scaling root planing (SRP) hand instruments. Clinical assessment plaque index (PI), gingival (GI),...

Background: Micro‐computed tomography (micro‐CT) offers significant potential for identifying mineralized structures. However, three‐dimensional (3‐D) micro‐CT of alveolar bone has not been adapted readily quantification. Moreover, conventional methods are highly sensitive analyzing loss or gain following periodontal disease reconstructive therapy. The objective this investigation was to develop a methodology quantifying tooth‐supporting in 3‐D experimental preclinical situations...

Background: Periodontitis, a complication of diabetes mellitus (DM), can induce or perpetuate systemic conditions. This double‐masked, placebo‐controlled study evaluated the effects periodontal therapy (scaling and root planing [SRP]) on serum levels glycated hemoglobin (HbA1c) inflammatory biomarkers. Methods: Thirty subjects with type 2 DM periodontitis were treated SRP + placebo (SRP; N = 15) doxycycline (SRP+Doxy; 15), 100 mg/day, for 14 days. Clinical laboratory data recorded at...

Background: Prevention of alveolar bone destruction is a clinical challenge in periodontal disease treatment. The receptor activator nuclear factor‐kappa B ligand (RANKL) inhibitor osteoprotegerin (OPG) inhibits osteoclastogenesis and suppresses resorption. Methods: To study the effects RANKL inhibition on loss, an experimental ligature‐induced model periodontitis was used. A total 32 rats were administered human OPG‐Fc fusion protein (10 mg/kg) or vehicle by subcutaneous delivery twice...

Background: Diabetes and periodontitis produce a protein discharge that can be reflected in saliva. This study evaluates the salivary concentrations of interleukin (IL)‐6, matrix metalloproteinase (MMP)‐8, osteoprotegerin (OPG) patients with type 2 diabetes. Methods: Whole saliva samples were obtained from 90 subjects who divided into four groups: healthy (control; n = 22), untreated (UPD; 24), diabetes mellitus (DM; 20), UPD + DM (n 24) groups. Clinical metabolic data recorded. Salivary...

Background: Aggressive periodontitis is a specific form of periodontal disease that characterized by rapid attachment loss and bone destruction. Cytokine profiles are considerable value when studying course during treatment. The aim this trial was to investigate cytokine levels in the gingival crevicular fluid (GCF) patients with aggressive periodontitis, after treatment photodynamic therapy (PDT) or scaling root planing (SRP), split‐mouth design on −7, 0, +1, +7, +30, +90 days. Methods: Ten...

Marcaccini AM, Meschiari CA, Zuardi LR, de Sousa TS, Taba M, Teofilo JM, Jacob‐Ferreira ALB, Tanus‐Santos JE, Novaes AB, Gerlach RF. Gingival crevicular fluid levels of MMP‐8, MMP‐9, TIMP‐2, and MPO decrease after periodontal therapy. J Clin Periodontol 2010; 37: 180–190. doi: 10.1111/j.1600‐051X.2009.01512.x . Abstract Background: This study aimed at comparing the matrix metalloproteinase (MMP)‐8, tissue Inhibitor MMPs (TIMP)‐1 Myeloperoxidase (MPO), MMP‐9 in gingival (GCF) chronic...

Background: The management of aggressive periodontitis (AgP) represents a challenge for clinicians because there are no standardized protocols an efficient control the disease. This randomized controlled clinical trial evaluated effects repeated applications antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in patients with AgP. Methods: Using split‐mouth design, 20 generalized AgP were treated aPDT + SRP (test group) or only (control group). was applied...

This study evaluates the effect of periodontitis on masticatory performance and quality life index.Patients (n = 24; 23 to 76 years age) with periodontal conditions ranging from healthy generalized disease categorized by alveolar bone height-to-tooth length (AB/T) ratio were separated into following two groups: control (AB/T >50%) test <50%). The was evaluated through continuous mastication a special device called biocapsule. Brazilian Oral Health Impact Profile (OHIP-14Br) questionnaire...

Background: With increase in the incidence of resistance to antibiotics, probiotics are emerging as a promising adjunctive periodontal therapy. The authors this study evaluate influence probiotic (PROB) supplementation on ligature‐induced periodontitis (LIP) and intestinal morphology rats. Methods: Thirty‐two rats were randomly divided into four groups: control (C), LIP, PROB, LIP/PROB. In groups PROB LIP/PROB, was administered orally by addition drinking water animals for 44 days. LIP...

Background: This study evaluates effects of topical administration probiotic bacteria the genus Bifidobacterium on experimental periodontitis (EP) in rats. Methods: Thirty‐two rats were divided into groups C (control; without EP), EP (EP only), C‐HN019 (control+probiotic), and EP‐HN019 (EP+probiotic). On day 0 experiment, animals received cotton ligatures around mandibular first molars (MFMs). In EP‐HN019, 1 mL suspensions containing animalis subsp. lactis ( B. ) HN019 was topically...

A challenge in the tissue engineering of alveolar bone surrounding oral or dental implants is achieving targeted and sustained delivery growth-promoting molecules at osteotomy site. Bone morphogenetic protein-7 (BMP-7) has demonstrated ability to stimulate regeneration multiple skeletal sites, including craniofacial complex. This study evaluates vivo gene BMP-7 for around titanium implants. The maxillary first molar teeth 44 Sprague-Dawley rats were extracted allowed heal a period 1 month....

Different techniques have been proposed for the treatment of gingival recessions. This study compared clinical results recession using a subepithelial connective tissue graft and an acellular dermal matrix allograft.Nine patients with bilateral Miller Class I or II recessions were selected. A total 30 treated randomly assigned to test group contralateral control group. In group, exposed root surfaces by placement in combination coronally positioned flap; allograft was used as substitute...

Background: The aim of this randomized, controlled, clinical investigation was to compare two surgical techniques for root coverage with the acellular dermal matrix graft evaluate which technique provided better coverage, a esthetic result, and less postoperative discomfort. Methods: Fifteen patients bilateral Miller Class I or II gingival recessions were selected. pairs treated assigned randomly test group, contralateral control group. group broader flap vertical releasing incisions;...

Background and Purpose: The resorption of alveolar bone following tooth extraction results in a narrowing shortening the residual ridge, which leads to esthetic restorative problems, reduces volume available for implant therapy. aim this study was evaluate prevention collapse after extraction, using titanium membrane (Frios Boneshield; DENTSPLY Friadent, Mannheim, Germany), associated (or not) with autologous graft. Materials Methods: A total 10 nonsmoking healthy subjects, ranging from 35...

Abstract Aim This double‐blind, placebo‐controlled clinical study compared multiple applications of the antimicrobial photodynamic therapy (aPDT) treatment protocol, to systemic doxycycline as adjuvant scaling and root planing (SRP) on type 2 diabetic patients clinical, immune‐inflammatory outcomes. Materials Methods Thirty with Hba1c &gt;7% were allocated in two groups, SRP + Doxy ( n = 15) using 100 mg/day (14 days) aPDT (0, 3, 7 14 days). Primary outcome was glycated haemoglobin levels...

Periodontal pathogenesis takes into consideration that disease results from a complex inflammatory immune response. Among the major cytokines related to periodontal damage, interleukin (IL)-6 enhances cascade of tissue destruction. Tocilizumab (TCZ) is humanized monoclonal anti-human IL-6 receptor inhibits IL-6-mediated proinflammatory activity. This study aimed elucidate whether TCZ deleterious effect ligature-induced periodontitis.Experimental periodontitis was treated with systemic...

This study evaluated the clinical and tomographic outcomes of socket healing. Immediate implants were placed in molar area, gap was filled with either deproteinized bovine bone mineral (B) or collagen matrix (BM), n = 14/group. Scores epithelization healing, immunoassay for VEGF, IL-1β, FGF from wound exudate, keratinized mucosa variation (ΔKM), levels evaluated. The B group had slower tissue maturation than BM (p &lt; 0.05), but gingival epithelialization similar &gt; 0.05). At restorative...