A5003876335- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Oral microbiology and periodontitis research
- Monoclonal and Polyclonal Antibodies Research
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Viral-associated cancers and disorders
- Plant Pathogens and Fungal Diseases
- T-cell and Retrovirus Studies
- Cytokine Signaling Pathways and Interactions
- Parvovirus B19 Infection Studies
- Urticaria and Related Conditions
- Viral Infections and Vectors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Oral and gingival health research
- Cellular transport and secretion
- Insect symbiosis and bacterial influences
- Systemic Sclerosis and Related Diseases
- Microbial Metabolic Engineering and Bioproduction
- HIV/AIDS oral health manifestations
- HIV Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
Universidade de São Paulo
2006-2023
University of Turin
2022
Universidade de Ribeirão Preto
2002-2016
Immungenetics (Germany)
2009
Background: Periodontitis, a complication of diabetes mellitus (DM), can induce or perpetuate systemic conditions. This double‐masked, placebo‐controlled study evaluated the effects periodontal therapy (scaling and root planing [SRP]) on serum levels glycated hemoglobin (HbA1c) inflammatory biomarkers. Methods: Thirty subjects with type 2 DM periodontitis were treated SRP + placebo (SRP; N = 15) doxycycline (SRP+Doxy; 15), 100 mg/day, for 14 days. Clinical laboratory data recorded at...
Background: Diabetes and periodontitis produce a protein discharge that can be reflected in saliva. This study evaluates the salivary concentrations of interleukin (IL)‐6, matrix metalloproteinase (MMP)‐8, osteoprotegerin (OPG) patients with type 2 diabetes. Methods: Whole saliva samples were obtained from 90 subjects who divided into four groups: healthy (control; n = 22), untreated (UPD; 24), diabetes mellitus (DM; 20), UPD + DM (n 24) groups. Clinical metabolic data recorded. Salivary...
Advances in diagnostic research are moving towards methods whereby the periodontal risk can be identified and quantified by objective measures using biomarkers. Patients with periodontitis may have elevated circulating levels of specific inflammatory markers that correlated to severity disease. The purpose this study was evaluate whether differences serum biomarkers differentially expressed healthy patients. Twenty-five patients (8 17 chronic patients) were enrolled study. A 15 mL blood...
Fungi have evolved elaborate signal transduction networks for remodeling metabolic pathways to scavenge nutrients, including the secretion of nutritional enzymes.This adaptive response involves conserved PacC/Pal pathway, which mediates transcriptional ambient pH.In this study, we show that transcription gene PacC is modulated in nutrient changes, phosphate and carbon sources, addition, pacC alternative RNA splicing palB gene.These results reveal novel aspects complex network involved...
Abstract Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia commonly affecting children with frequent somatic mutations in MAPK pathway genes including BRAF V600E and MAP2K1. Some studies suggest that LCH cells can recruit modulate cells, which could provide reciprocal survival signals. To characterize the immune profile of infiltrating to clarify their participation pathogenesis, a detailed immunohistochemical analysis was performed. Fifteen (10 children, 5 adults)...
The growth and development of organisms depend on nutrient availability. Dermatophytes must sense levels adapt to the host environment colonize human animal keratinized tissues. Owing clinical importance Trichophyton genus, this study compared expression profile genes involved in metabolism, cell cycle control, proteases two species, rubrum , interdigitale response nutrients environmental pH. In addition, we evaluated activity enzymes tricarboxylic acid, glyoxylate, methylcitrate cycles....
Patients presenting with active systemic lupus erythematosus (SLE) manifestations may exhibit distinct pathogenetic features in relation to inactive SLE. Also, cDNA microarrays potentially discriminate the gene expression profile of a disease or variant. Therefore, we evaluated 4500 genes peripheral blood lymphocytes (PBL) SLE patients. We studied 11 patients (seven and four SLE) eight healthy controls. Total RNA was isolated from PBL, reverse transcribed into cDNA, postlabeled Cy3...
In fungi, ambient pH sensing involves the activation of Pal/PacC signalling pathway. dermatophyte Trichophyton rubrum, pH-dependent secretion keratinases, which are major virulence determinants, is affected by disruption pacC gene. Here, transcription profiling genes coding for N- and O-linked mannosyltransferases, enzymes involved in protein glycosylation, was evaluated T. rubrum response to gene growth keratin, glucose, glucose plus glycine. We show that these mannosyltransferase nutrients...
The SET gene has four transcripts reported in NCBI, coding two isoforms of proteins. most known function protein is inhibiting phosphatase 2A, a tumor suppressor, which been associated with different biological processes. In this review, our focus was on exploring the other functions related to epigenetic mechanisms, impact cellular migration, cell cycle and apoptosis.
Plasmablastic lymphoma (PBL) is a rare B-cell occurring mainly in HIV patients. The tumor frequently involves extranodal sites such as the oral cavity, nasal gastrointestinal tract, skin, and lungs. neoplastic cells are characterized by plasmablastic appearance typical immunophenotype that indicates plasma cell differentiation. Herein, we report case of intraocular involvement patient with long history cytomegalovirus retinitis loss vision. After an evisceration performed to control blind,...
Abstract To evaluate the distribution of usage and to quantify transcription levels immunoglobulin lambda variable ( IGLV ) genes in patients with systemic lupus erythematosus (SLE) normal individuals (NIs), cDNA samples from peripheral blood lymphocytes were prepared probed IGLV‐specific oligonucleotides. Because recombinations involving V‐lambda pseudogenes are nonproductive, we analysed productive repertoire, as cDNAs copied mRNA producing B lymphocytes. Increased expression IGLV8a gene...
Neste trabalho, analisaram-se comparativamente as seqüências de nucleotídios dos genes das proteínas estruturais C, prM e E todos os Flavivirus, incluindo, também, a região 5’ não codificadora, 21 Flavivirus. Utilizou-se para análise o programa microcomputador DNAsis (Hitachi, Japão) construiu-se uma árvore filogenética, incluindo vinte um (21) vírus, após alinhamento suas nucleotídios. Na filogenética obtida, observou-se ramificação inicial, separando vírus transmitidos por carrapatos...
Background: Doravirine (DOR) and Rilpivirine (RPV) are the NNRTIs currently most used in clinical setting, dual triple drug regimens (2DR 3DR). Intracellular (IC) Pharmacokinetics (PK) of these drugs has not been fully elucidated. Our aim was to compare plasma PK IC accumulation real-life experienced patients (pts). Methods: Pts on DOR- RPV-including Antiretroviral (ARV) regimen were considered. DOR RPV (PBMCs) concentrations measured at 12 (37%) (T12) 24 ± 4 hours (63%) (T24) after last...