A5065875467- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Sexual function and dysfunction studies
- Hormonal Regulation and Hypertension
- Ovarian cancer diagnosis and treatment
- Hypothalamic control of reproductive hormones
- Sexual Differentiation and Disorders
- Lung Cancer Research Studies
- Ovarian function and disorders
- Cardiovascular Disease and Adiposity
- Neonatal Health and Biochemistry
- Dermatological and COVID-19 studies
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Estrogen and related hormone effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Chemical Analysis and Environmental Impact
University of Campania "Luigi Vanvitelli"
2012-2024
ASL Roma
2022-2024
University of Salerno
2022-2023
Association for Symbolic Logic
2023
University of Turin
2022
Policlinico S.Orsola-Malpighi
2019
University of Bologna
2019
University of Naples Federico II
2013-2016
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2012
This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating potential early treatment with oral semaglutide. A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals T2D. scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, physician judgments on appropriateness. Participants completed anonymous...
We investigated whether chronotype is associated with glycemic control, antidiabetic treatment, and risk of developing complications in patients type 2 diabetes (T2DM).The diabetologists filled out an online questionnaire on the Google Form platform to collect following parameters subjects T2DM: body mass index (BMI), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), history, diabetic complications, categories.We enrolled 106 T2DM (M/F: 58/48; age: 63.3 ± 10.4 years; BMI: 28.8...
Background: Endocrine gland-derived vascular endothelial growth factor (Prok1) and prokineticin 2 (Prok2) are involved in the organ-specific regulation of angiogenesis, which is a crucial step toward cancer progression most tumors, including those thyroid gland. The oncogene BRAF V600E mutation associated with poor clinical outcome papillary (PTC) can independently predict its recurrence. Design: Our hypothesis was that Prok1 Prok2 expression levels mutations be prognostic factors for PTC...
Klinefelter syndrome (KS) is a hypergonadotropic hypogonadism characterized by 47, XXY karyotype. The risk of testicular cancer in KS interest relation to theories about etiology generally; nevertheless it seems be low. We evaluated the need for imaging and serum tumor markers screening KS. Participants were 40 consecutive patients, enrolled from December 2009 January 2013. Lactate dehydrogenase (LDH), alpha-fetoprotein (AFP), beta-human chorionic gonadotrophin subunit (β-HCG) levels assays...
CDKN1B encodes the cyclin-dependent kinase inhibitor p27Kip1 and is mutated in multiple endocrine neoplasia-like syndromes. also harbors single nucleotide polymorphisms; T/G transversion at 326 (the V109G variant) has been reported to be protective breast, hereditary prostate, pancreatic tumors. Association of CDNK1B mutations or polymorphisms with sporadic medullary thyroid carcinoma (MTC) not investigated yet.We screened germline DNA from 84 patients affected by MTC 90 healthy age-...
Patients with Klinefelter syndrome (KS) exhibit an increased cardiovascular risk, but underlying mechanisms are largely unknown. The present cross-sectional study has been conducted to evaluate platelet reactivity and the expression of activation markers (8-iso-prostaglandin F2α[8-iso-PGF2α] 11-dehydro-thromboxane-B₂[11-dehydro-TXB2]) in KS patients healthy controls. Twenty-three consecutive under testosterone replacement therapy have included as case group 46 age-matched males recruited...
Abstract Purpose We aimed to verify if 1 year-testosterone-replacement therapy could produce a psychopathological recovery and satisfactory quality of life in Klinefelter syndrome (KS) patients compared matched healthy controls. Further, we analyzed personality traits coping strategies, an issue not yet examined androgen-treated KS patients. also enquired whether any the sociodemographic psychological variables might predict patient’s general sexual satisfaction. Methods The Quality Life...
Abstract Context Patients with adrenal insufficiency (AI) have excess mortality and morbidity, mainly due to cardiovascular (CV) diseases. The mechanisms for this is unclear. Objective To assess CV structure function in AI patients on conventional replacement therapy after switching once-daily, modified-release hydrocortisone (OD-HC) comparison healthy matched controls. Methods This was a retrospective analysis of 17 adult (11 primary AI, 6 secondary AI) stable cortisone acetate [median...
Background and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of artery disease (CAD) plaque vulnerability. This effect can be related to endocrine paracrine molecules produced by epicardial (EAT), that may influence myocardial contractility. Using computed tomography angiography (CCT) the evaluation EAD is possible in basal scans. The aim study investigate associations between cardiac function. Material Methods: 93...
Type IIIb polyglandular autoimmune disease comprises thyroid (HT) and chronic atrophic gastritis (AIG). Hypergastrinemia, secondary to AIG, predisposes gastric enterochromaffin-like cell (ECL) hyperplasia, a preneoplastic condition. We evaluated the prevalence of hypergastrinemia ECL hyperplasia in HT patients. A end-point was assess efficacy treatment with somatostatin analogue patient hyperplasia. From 2009 2011, 146 patients were enrolled prospective study. All cases underwent hormonal...