A5004808448- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Soil Management and Crop Yield
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Syphilis Diagnosis and Treatment
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Science and Education Research
- Global Maternal and Child Health
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Immune responses and vaccinations
- Health Education and Validation
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Zoonotic diseases and public health
- Diabetes and associated disorders
- Leprosy Research and Treatment
- Toxoplasma gondii Research Studies
- Rabies epidemiology and control
- Inflammation biomarkers and pathways
- Healthcare during COVID-19 Pandemic
- Evasion and Academic Success Factors
Universidade Federal de Sergipe
2015-2025
Amazon Research Foundation
2024
Weatherford College
2020
Universidade de São Paulo
2020
Jorge Amado University Center
2020
Faculdades Oswaldo Cruz
2020
Instituto de Botânica
2020
Background Visceral leishmaniasis (VL) is a severe disease caused by infection with protozoa of the genus Leishmania. Classic VL characterized systemic phagocytic cells and an intense activation inflammatory response. It unclear why 90% infected individuals do not develop while minority classical form. Furthermore, among those that disease, small group progresses to more form unresponsive treatment. The presence mediators in serum could theoretically help control infection. However, there...
Background Despite visceral leishmaniasis (VL) being epidemic in most Brazilian regions, the Northeast region is responsible for highest morbidity and mortality outcomes within country. Objective To analyse spatiotemporal dynamics of VL cases to identify temporal trends high-risk areas transmission, as well association disease with social vulnerability Northeast. Methods We carried out an ecological time series study employing spatial analysis techniques using all confirmed 1,794...
Abstract Congenital Zika syndrome (CZS) is a cluster of malformations induced by virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological environmental factors, genetic host factors suggested as important to CZS development, however, few studies have evaluated this. This study enrolled total 245 individuals case–control association compound cohort high specific interest constituted 75 mothers who had delivered...
Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play critical role in the development of this disease. Here, we perform prospective exploratory study addressing whether simultaneous assessment circulating levels different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. patients displayed substantial increases serum Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin D1 (RvD1),...
This study evaluated the clinical and tomographic outcomes of socket healing. Immediate implants were placed in molar area, gap was filled with either deproteinized bovine bone mineral (B) or collagen matrix (BM), n = 14/group. Scores epithelization healing, immunoassay for VEGF, IL-1β, FGF from wound exudate, keratinized mucosa variation (ΔKM), levels evaluated. The B group had slower tissue maturation than BM (p < 0.05), but gingival epithelialization similar > 0.05). At restorative...
No vaccine is currently licensed against human visceral leishmaniasis (VL), a fatal CD4+ T cell immunosupressive disease which chemotherapy reduced to few toxic drugs. The NH36 nucleoside hydrolase DNA metabolism vital enzyme present in all Leishmania species. A based on such conserved antigen could protect both VL and cutaneous leishmaniasis, whose epidemics geographically overlap. Increased frequencies of NH36-specific IL-2+TNF-α+IFN-γ+-producing cells were associated with immune...
It is well established that helper T cell responses influence resistance or susceptibility to Mycobacterium leprae infection, but the role of more recently described subsets in determining severity less clear. To investigate involvement Th17 cells pathogenesis leprosy, we determined immune profile with variant presentations leprosy. Firstly, IL-17A, IFN-γ and IL-10 were evaluated conjunction CD4+ staining by confocal microscopy lesion biopsies from tuberculoid (TT) lepromatous leprosy (LL)...
This report documents the first known cases of lepromatous leprosy in patients with chronic mucocutaneous candidiasis (CMC) linked to a gain-of-function mutation STAT1 gene. Two related patients, mother and daughter, who both suffer from CMC leprosy, carry heterozygous (c.821G>A; p.R274Q). Both individuals exhibited similarly high levels total phosphorylated CD4+ T cells decreased interleukin 17A transcripts. underscores complex relationship between genetic susceptibility infections...
Abstract Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, growth factors in 12 patients with concurrent CHIKV ZIKV infections confirmed by RT-qPCR. Clinical data 45 immune mediators were analyzed. Coinfected monoinfected exhibited similar symptoms, although ZIKV-infected individuals experienced fewer instances fever. No had persistent symptoms or...
Recurrent COVID-19, defined as two or more distinct episodes, may reflect an impaired immune response to SARS-CoV-2. In this case–control study, we compared three groups: individuals with recurrent those a single episode, and SARS-CoV-2-naïve controls. We genotyped six immune-related SNPs, including TLR7 rs179008, measured CD4+ CD8+ T cell responses SARS-CoV-2 antigens using flow cytometry. The allele of previously linked reduced receptor expression, was significantly overrepresented in the...
INTRODUCTION: Considering that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in feces, this study aimed to verify a possible relationship between basic sanitation indices and disease (COVID-19) numbers/rates. METHODS: Data of COVID-19 cases registered Brazil until May 28, 2020, independent variables associated with were analyzed. RESULTS: A significant correlation the number sewage treatment index/population density was observed. In addition, incidence...
Nitric oxide (NO) plays an important role as a leishmanicidal agent in murine macrophages. NO resistant Escherichia coli and Mycobacterium tuberculosis have been associated with poor outcomes of their resulting diseases. Leishmania braziliensis has also identified exacerbates the clinical course human leishmaniasis. We report, for first time, natural resistance chagasi promastigotes to NO. These parasites were isolated from humans dogs visceral demonstrate that this profile was greater...
Abstract Background Basic sanitation could be a potential indicator of the spread coronavirus disease-2019 (COVID-19) and, in this context, space-time patterns are important tools with which to elucidate disease and identify risk factors. The aim study was assess possible association between basic indices COVID-19 rates all 5570 municipalities Brazil its spatial distribution. Methods Data cases registered from 28 February until 31 May 2020 independent variables associated were included....
Background While CD40L is typically a membrane glycoprotein expressed on activated T cells and platelets that binds activates CD40 the surface antigen presenting cells, soluble derivative (sCD40L) appears to retain its biological activity after cleavage from cell also exists. We recently reported sCD40L associated with clinical resolution of visceral leishmaniasis protection against disease. In present study we investigated if this functional exerts anti-parasitic effect in L....
Leishmania spp are the causative agents of a spectrum diseases termed leishmaniasis that affect mammals, including humans and dogs.Although reactive nitrogen species employed in control parasitism by immune system, it is known can withstand this oxidative stress.As mechanism which these resistant to nitric oxide (NO) poorly understood, main objective study was evaluate expression glyceraldehyde 3-phosphate dehydrogenase (GAPDH) amazonensis chagasi promastigotes ©FUNPEC-RP...
This investigation aimed to assess the effect of N-acetylcysteine (NAC) as an adjuvant treatment alleviate visceral leishmaniasis (VL). The present work includes both blinded randomized clinical intervention and experimental in vitro studies. trial included 60 patients with VL randomly allocated into two groups: a test group (n = 30) treated meglumine antimoniate plus NAC (SbV + NAC) control only (SbV). primary outcome was cure (absence fever, spleen liver sizes reduction, hematological...
RESUMOObjetivo: analisar o conhecimento de enfermeiros da Estratégia Saúde Família sobre a tuberculose. Método: trata-se estudo quantitativo, descritivo e transversal, com 22 enfermeiras. Utilizou-se, como instrumento coleta, um questionário estruturado adaptado. Descreveram-se as variáveis numéricas média desvio padrão sumarizaram-se categóricas em frequências simples porcentagens partir tabelas. Resultados: revelou-se, quanto ao recebimento capacitação temática tuberculose, que 77,27%...