A5010450700- Parasites and Host Interactions
- Global Cancer Incidence and Screening
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Colorectal Cancer Screening and Detection
- Healthcare Regulation
- Child Nutrition and Water Access
- Health, Nursing, Elderly Care
- Environmental and biological studies
- Cancer Risks and Factors
- Viral Infections and Vectors
- Science and Education Research
- Healthcare during COVID-19 Pandemic
- Prostate Cancer Diagnosis and Treatment
- Mosquito-borne diseases and control
- Blood donation and transfusion practices
- Health Education and Validation
- Public Health in Brazil
- Adolescent Sexual and Reproductive Health
- Male Reproductive Health Studies
- HIV-related health complications and treatments
- Aquatic Ecosystems and Phytoplankton Dynamics
- Diatoms and Algae Research
- T-cell and Retrovirus Studies
- Education during COVID-19 pandemic
Universidade Federal de Sergipe
2013-2025
Instituto de Tecnologia e Pesquisa
2021
Weatherford College
2020
Universidade Católica Dom Bosco
2012
Universidade Federal do Paraná
2010
Abstract Congenital Zika syndrome (CZS) is a cluster of malformations induced by virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological environmental factors, genetic host factors suggested as important to CZS development, however, few studies have evaluated this. This study enrolled total 245 individuals case–control association compound cohort high specific interest constituted 75 mothers who had delivered...
OBJECTIVE: Estimate the prevalence of common mental disorder and its associated factors among medical students Universidade Federal de Sergipe. METHOD: A cross-sectional study was carried out, applying Self Reporting Questionnaire-20 to 473 from 512 enrolled in 2006 compared with a structured questionnaire by authors containing information on socio-demographic characteristics, teaching-learning process psycho-emotional experiences students. Freshmen were excluded after initial comparison...
INTRODUÇÃO: A esquistossomose é endêmica no Brasil, com elevada prevalência Estado de Sergipe, apesar da existência do Programa Controle Esquistossomose (PCE). MÉTODOS: Foi realizado levantamento dados PCE-Sergipe 2005 a 2008. partir matriz bruta formulou-se planilha software Access e analisou-se frequência distribuição geográfica das infecções por Schistosoma mansoni outros enteroparasitos. Estes foram exportados para o Spring 5.0.5 georreferenciamento confecção mapas temáticos espacial...
No vaccine is currently licensed against human visceral leishmaniasis (VL), a fatal CD4+ T cell immunosupressive disease which chemotherapy reduced to few toxic drugs. The NH36 nucleoside hydrolase DNA metabolism vital enzyme present in all Leishmania species. A based on such conserved antigen could protect both VL and cutaneous leishmaniasis, whose epidemics geographically overlap. Increased frequencies of NH36-specific IL-2+TNF-α+IFN-γ+-producing cells were associated with immune...
Santos et al. analyzed the clinical characteristics and pulmonary function of children with cystic fibrosis infected SARS-CoV-2. Infected showed higher rates dyspnea, coughing, hospitalization, exacerbations. Despite a temporary decline in function, recovery matched those uninfected during follow-up. ■ SARS-CoV-2 infection leads to mild-to-moderate disease fibrosis. No worsening was observed months after infection. This study aimed evaluate manifestations adolescents case-control analysis...
O estudo sobre a diversidade das diatomáceas do reservatório Iraí ampliou o conhecimento da flora diatomológica perifítica de ambientes eutróficos estado Paraná e contribuiu para subsidiar futuros trabalhos que utilizem como bioindicadoras condições tróficas água. Coletas trimestrais foram realizadas no durante um ano. As amostras perifíticas obtidas pela remoção biofilme aderido caules macrófita Polygonum sp. lâminas vidro. Estas colocadas em complexos madeira deixadas submersas 30 dias...
Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status, particularly 1.4 billion people who living below poverty level. This study has investigated magnitude and mortality time trends for these in state Sergipe, Northeast Region Brazil. We conducted an ecological series, based on secondary data derived from Mortality Information System Ministry Health. The rates (crude, age-standardized proportional ratio) were calculated deaths...
Introduction In VL, a proinflammatory phenotype is typically associated with enhanced phagocytosis and Th1 mediated immune response resulting in infection control. contrast, an anti-inflammatory phenotype, predominant regulatory response, enables intracellular multiplication of Leishmania parasites disease progression. Methods To investigate the impact chemotherapy on Th2 Th17 responses patients visceral leishmaniasis (VL), we assessed all combinations expression IFN-γ, IL-10, IL-4 IL-17 CD4...
This report documents the first known cases of lepromatous leprosy in patients with chronic mucocutaneous candidiasis (CMC) linked to a gain-of-function mutation STAT1 gene. Two related patients, mother and daughter, who both suffer from CMC leprosy, carry heterozygous (c.821G>A; p.R274Q). Both individuals exhibited similarly high levels total phosphorylated CD4+ T cells decreased interleukin 17A transcripts. underscores complex relationship between genetic susceptibility infections...
Abstract Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, growth factors in 12 patients with concurrent CHIKV ZIKV infections confirmed by RT-qPCR. Clinical data 45 immune mediators were analyzed. Coinfected monoinfected exhibited similar symptoms, although ZIKV-infected individuals experienced fewer instances fever. No had persistent symptoms or...
Leprosy remains a significant public health challenge despite diagnostic advances. This cross-sectional study evaluated the social and clinical characteristics of 302 patients treated at reference outpatient clinic in northeastern Brazil (2010-2019). Men more frequently presented with multibacillary disease disabilities than women. These men were associated higher rates alcohol consumption hunting. No evidence was found for an association between delays severity. underscores that...
Recurrent COVID-19, defined as two or more distinct episodes, may reflect an impaired immune response to SARS-CoV-2. In this case–control study, we compared three groups: individuals with recurrent those a single episode, and SARS-CoV-2-naïve controls. We genotyped six immune-related SNPs, including TLR7 rs179008, measured CD4+ CD8+ T cell responses SARS-CoV-2 antigens using flow cytometry. The allele of previously linked reduced receptor expression, was significantly overrepresented in the...
This is a case series study to evaluate immunological markers associated with schistosomiasis advanced fibrosis, including 69 patients from an endemic area the State of Sergipe and Hepatology Service University Hospital in Sergipe, Brazil. Hepatic fibrosis was classified based on Niamey protocol for ultrasonography (US). Immune response Schistosoma mansoni antigens evaluated by stimulating peripheral blood mononuclear cells (PBMCs) these either adult worm (SWAP-10 μg/ml) or egg (SEA-10...
Visceral leishmaniasis (VL) is a vector-borne infectious disease that can be potentially fatal if left untreated. In Brazil, it caused by Leishmania infantum parasites. Blood transcriptomics allows us to assess the molecular mechanisms involved in immunopathological processes of several clinical conditions, namely, parasitic diseases. Here, we performed mRNA sequencing peripheral blood from patients with visceral during active phase and six months after successful treatment, when were...
Background While CD40L is typically a membrane glycoprotein expressed on activated T cells and platelets that binds activates CD40 the surface antigen presenting cells, soluble derivative (sCD40L) appears to retain its biological activity after cleavage from cell also exists. We recently reported sCD40L associated with clinical resolution of visceral leishmaniasis protection against disease. In present study we investigated if this functional exerts anti-parasitic effect in L....
Cervical cancer is a health issue that disproportionately affects developing countries, where the Papanicolaou test (Pap smear) remains an important screening tool. Brazilian government recommendations have focused on female population aged from 25 to 64 years old. In this study, we examined incidence and mortality rates of invasive cervical lesions in situ precancerous lesions, aiming calculate their respective statistics over time mid-sized city, Aracaju. The 1996–2015 database Aracaju...
Prostate cancer differently affects different regions of the world, displaying higher rates in more developed areas. After implementation prostate-specific antigen (PSA) testing, several studies described rising globally, but it is possible that indolent lesions are being detected given lack changes mortality data. The Brazilian government recommends against PSA screening male population regardless age, Urology Society issued a report recommending should start at 50 years old for certain men...
INTRODUÇÃO: A leptospirose, enfermidade causada por uma espiroqueta patogênica do gênero Leptospira, é das zoonoses mais difundidas no mundo, considerada um importante problema de saúde pública. Este trabalho tem como objetivo descrever o padrão espacial da leptospirose na Cidade Aracaju, período 2001 a 2007, buscando identificar as áreas risco para ocorrência leptospirose. MÉTODOS: Utilizou-se razão Kernel, que consiste criação entre duas superfícies, visualizar superfície doença, onde...
International data have reported prostate cancer as the most frequent among men, and third highest in mortality. A rise incidence has been observed course of recent decades, probably influenced by early detection, mainly asymptomatic through regular screening with prostate-specific antigen (PSA) testing. The purpose this study was to contribute information on trends mortality using population-based data.This an exploratory ecological time trends, aiming at describing changes Aracaju,...
OBJETIVO: Avaliar aspectos ultrassonográficos associados à morbidade em pacientes com formas clínicas crônicas de esquistossomose mansônica, utilizando-se protocolo proposto pela Organização Mundial da Saúde (OMS). MATERIAIS E MÉTODOS: Foram avaliadas duas populações distintas: a) área endêmica e b) institucional terciária, histopatológico confirmando fibrose. Critérios inclusão: diagnóstico confirmado por parasitológico fezes para Schistosoma mansoni (método Kato-Katz). exclusão: sorologia...
Breast cancer incidence within an area is usually proportional to the area’s income level. High-income areas have shown highest rates and since 2003, negative trends. As for mortality, are often higher in low-income regions. The purpose of this study was analyze trends mortality a capital city northeastern Brazilian state with intermediate human development index. Incidence data from Population-Based Cancer Registry Aracaju Official State Database period 1996–2006 were used. crude...
There have been arguments about the role of breast cancer screening at population level, and some points controversy arisen, such establishment organized policies age which to begin screening. The real benefit has questioned because results this practice may increase diagnosis indolent lesions without decreasing mortality due cancer. authors proposed a study incidence trends for in developing setting Brazil monitor effectiveness official recommendations that prioritize group from 50 69...
This study aims at identifying ocular findings in infants with microcephaly associated presumed intrauterine infection by ZIKV. A cross-sectional included 62 outpatient congenital microcephaly, presumably secondary to maternal ZIKV infection. The had head circumference below -2 standard deviations, negative serology for toxoplasmosis, rubella, cytomegalovirus, syphilis, and HIV. Assessment of alterations was performed through review their medical records. Forty two (67.7%) the children...