A5022058737- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Exercise and Physiological Responses
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Cardiovascular Function and Risk Factors
- Endoplasmic Reticulum Stress and Disease
- Muscle metabolism and nutrition
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Fibromyalgia and Chronic Fatigue Syndrome Research
- PARP inhibition in cancer therapy
- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- Lower Extremity Biomechanics and Pathologies
- Tryptophan and brain disorders
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
Hospital del Mar Research Institute
2018-2022
Hospital Del Mar
2021-2022
Barcelona Biomedical Research Park
2015-2019
Universitat Pompeu Fabra
2015-2019
Municipal Institute for Medical Research
2015-2019
Parc de Salut
2015-2019
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2015-2019
Instituto de Salud Carlos III
2015-2019
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association disease severity crucial to understand pathophysiology, guide decisions. This study aimed at assessing critical in hospitalized patients. Forty-nine patients were enrolled a prospective, observational, single-center Barcelona, Spain. Demographic, clinical, analytical data admission registered. Plasma samples collected within...
Patients with chronic heart failure (CHF) experience exercise intolerance, fatigue and muscle wasting, which negatively influence their survival. We hypothesized that treatment either the antioxidant N-acetyl cysteine (NAC) or proteasome inhibitor bortezomib of rats monocrotaline-induced CHF may restore inspiratory limb mass, function, structure through several molecular mechanisms involved in protein breakdown metabolism diaphragm gastrocnemius. In these muscles CHF-cachectic without NAC (N...
Muscle wasting negatively impacts the progress of chronic diseases such as lung cancer (LC) and emphysema, which are in turn interrelated. We hypothesized that muscle atrophy body weight loss may develop an experimental mouse model carcinogenesis, profile alterations fiber phenotype (fiber type composition morphometry, structural alterations, nuclear apoptosis), metabolism similar both respiratory limb muscles tumor-bearing mice, presence underlying emphysema influence those events....
Abstract Impaired muscle strength and mass (sarcopenia) are common in patients with respiratory cachexia, namely chronic obstructive pulmonary disease (COPD) lung cancer (LC)‐cachexia. Misfolded/unfolded proteins endoplasmic reticulum (ER) induce the compensatory unfolded protein response (UPR). Expression of ER stress UPR markers may be differentially upregulated vastus lateralis (VL) sarcopenia associated either a condition or subacute In VL specimens from 40 COPD ( n = 21, sarcopenic,...
Peripheral muscle weakness and mass loss are characteristic features in severe chronic obstructive pulmonary disease (COPD). We hypothesized that the phosphodiesterase (PDE)-4 inhibitor roflumilast-induced cAMP may ameliorate proteolysis metabolism skeletal muscles of COPD patients with wasting. In myogenic precursor cells (isolated from biopsies cultured up to obtain differentiated myotubes) 10 healthy controls, which were treated 1 μM roflumilast N-oxide (RNO) for three time cohorts (1, 6,...
Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent development emphysema pulmonary vascular remodeling in animal models chronic obstructive disease (COPD). The aim this study was evaluate effects sGC on oxidative stress plasma guinea pigs chronically exposed cigarette smoke (CS).Guinea were CS or sham for three months, received either stimulator BAY...
Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be attenuated in response to treatment beta2-adrenoceptor-selective agonist formoterol rats. In diaphragm gastrocnemius tumor-bearing rats (108 AH-130 Yoshida ascites hepatoma cells inoculated intraperitoneally) without (0.3 mg/kg body weight/day for seven days, daily subcutaneous...
Abstract Identification of to what extent tumor burden influences muscle mass independently specific treatments for cancer‐cachexia remains be elucidated. We hypothesized that reduced by selective treatment with immunomodulators may exert beneficial effects on wasting and function in mice. Body weight, grip strength, physical activity, morphometry, apoptotic nuclei, troponin‐I systemic levels, interleukin‐6, proteolytic markers, tyrosine release, apoptosis markers were determined diaphragm...
Respiratory muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Chronic contractile activity induces endoplasmic reticulum (ER) stress and unfolded protein response (UPR) animals (animals humans). We hypothesized that the respiratory associated COPD may upregulate ER UPR expression diaphragm of stable different degrees airway obstruction normal body composition. In specimens mild moderate-to-severe preserved composition non-COPD controls (thoracotomy...
Abstract Muscle wasting is associated with chronic diseases and cancer. Elucidation of the biological mechanism involved in process muscle mass loss cachexia may help identify therapeutic targets. We hypothesized that l ‐carnitine treatment differentially revert fiber atrophy other structural alterations slow‐ fast‐twitch limb muscles rats bearing Yoshida ascites hepatoma. In soleus gastrocnemius tumor‐bearing (10 8 AH‐130 hepatoma cells inoculated intraperitoneally) without (1 g/kg body...
Abstract Background Diaphragm fiber atrophy has been evidenced after short periods of mechanical ventilation (MV) and related to critical illness-associated diaphragm weakness. Atrophy is described as a decrease in cross-sectional area (CSA) human biopsy, but samples are still difficult obtain clinics. In recent years, ultrasound become useful tool intensive care evaluate anatomy. The present study aimed the ability expiratory thickness (Tdi) measured by predict atrophy, defined CSA obtained...
Quadriceps muscle weakness and wasting are common comorbidities in chronic obstructive pulmonary disease (COPD). Micro-RNA expression upregulation may favor mass growth differentiation. We hypothesized that the profile of muscle-enriched micro-RNAs cultured myotubes differs between patients with COPD a wide range body composition healthy controls levels those from differ vivo vitro conditions. Twenty-nine [ n = 15 fat-free index (FFMI) kg/m 2 14 normal FFMI 18 ] 10 (FFMI 19 ) were...