A5080927194- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Tuberculosis
- Infective Endocarditis Diagnosis and Management
- Knee injuries and reconstruction techniques
- Trauma and Emergency Care Studies
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Bone fractures and treatments
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Disaster Response and Management
- Musculoskeletal Disorders and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Surgical site infection prevention
- COVID-19 and healthcare impacts
- Orthopaedic implants and arthroplasty
University Hospital Münster
2012-2022
Staphylococcus aureus osteomyelitis often develops to chronicity despite antimicrobial treatments that have been found be susceptible in vitro tests. The complex infection strategies of S. aureus, including host cell invasion and intracellular persistence via the formation dynamic small colony variant (SCV) phenotypes, could responsible for therapy-refractory courses. To analyse efficacy antibiotics acute chronic stage bone infections, we established long-term vivo models. Antibiotics were...
Abstract Purpose In Dec 2019, COVID-19 was first recognized and led to a worldwide pandemic. The German government implemented shutdown in Mar 2020, affecting outpatient hospital care. aim of the present article evaluate impact on patient volumes surgical procedures Level I trauma center Germany. Methods All emergency patients were recorded retrospectively during compared calendar-matched control period (CTRL). Total contacts including mechanisms, injury patterns operation numbers absolute...
The rise of highly resistant bacteria creates a persistent urge to develop new antimicrobial agents. This paper investigates the application lipopeptide antibiotic daptomycin in infections involving human bone.Compressive and tensile strength testing daptomycin-laden PMMA was performed referring ISO 5833. microstructure antibiotic-laden evaluated by scanning electron microscopy. Intracellular activity determined osteoblast infection model. Elution kinetics bone cement measured using...
In the fields of traumatology and orthopaedics staphylococci are most frequently isolated pathogens. Staphylococcus aureus epidermidis known to be major causative agents osteomyelitis. The increasing number multiresistant resistant coagulase-negative as a trigger complicated osteomyelitis implant-associated infections is problem. Antibiotic therapy fails in 20% cases. Therefore development novel antibiotics becomes necessary. This study analyses tigecyclin, first antibiotic glycylines,...
Purpose: Several suture techniques have been described in the past for direct ACL repair with poor healing capacity and a high re-rupture rate. Therefore, we investigated refixation technique acute primary proximal repair. The purpose of this study is to compare biomechanical properties different configurations using knotless anchor. Methods: In study, 35 fresh-frozen porcine knees underwent refixation. First, 10 femora, anchor, without ligament attached, were tested. Then, three evaluated...
Infections caused by multidrug-resistant organisms (MDROs) are associated with prolonged hospitalization and higher risk of mortality. Patients arriving in the hospital via emergency department (ED) screened for presence MDROs compliance screening protocols order to apply correct isolation measures. In Dutch–German border region, local hospitals their own which based upon national protocols. The contents MDRO were compared on vancomycin-resistant enterococci (VRE), methicillin-resistant...
Abstract The increasing number of implant-associated infections and multiresistant pathogens is a major problem in the daily routine. In field osteomyelitis, it difficult to manage valid clinical study because multiple influencing factors. Therefore, models osteomyelitis with simulation pathophysiology evaluate treatment options for are necessary. aim this develop standardized reproducible model in-vivo improve options. This analyses influence post-infectious implant exchange one week after...
Zusammenfassung Schaftfrakturen der unteren Extremitäten im Kindesalter treten mit einer Häufigkeit von 14% auf und zeigen einen Altersgipfel zwischen dem 5. 6. Lebensjahr. Tibiaschaftfrakturen gehören dabei zu den häufigsten Frakturen Kindesalter. Die Behandlung Kindes- Wachstumsalter bedarf des Wissens um die besonderen biomechanischen physiologischen Eigenschaften kindlichen Knochens sowie operativen konservativen Therapiemaßnahmen. Auch bei Verletzungen – besonders diaphysären ist...