A5051889254- Hydrogen's biological and therapeutic effects
- Sphingolipid Metabolism and Signaling
- Biochemical effects in animals
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Neuroendocrine Tumor Research Advances
- interferon and immune responses
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Renal and related cancers
- Axon Guidance and Neuronal Signaling
- Endoplasmic Reticulum Stress and Disease
- Congenital gastrointestinal and neural anomalies
- Hedgehog Signaling Pathway Studies
- Dietary Effects on Health
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
Chubu University
2014-2024
Nagoya University
2000-2024
Ogaki Municipal Hospital
2017
Nagoya City University
2006-2012
Gifu University
2012
Gifu Pharmaceutical University
2012
Tokai Gakuen University
2012
RMIT University
2007
The University of Tokyo
1997
Merck (Japan)
1997
Therapeutic effects of molecular hydrogen for a wide range disease models and human diseases have been investigated since 2007. A total 321 original articles published from 2007 to June 2015. Most studies conducted in Japan, China, the USA. About three-quarters show mice rats. The number clinical trials is increasing every year. In most diseases, effect has reported with water or gas, which was followed by confirmation hydrogen-rich saline. Hydrogen mostly given ad libitum. gas less than 4 %...
Most mutations after DNA damage in yeast Saccharomyces cerevisiae are induced by error-prone translesion synthesis employing scRev1 and polymerase zeta that consists of scRev3 scRev7 proteins. Recently, the human REV1 (hREV1) REV3 (hREV3) genes were identified, their products revealed to be involved UV-induced mutagenesis, as observed for counterparts. Human REV7 (hREV7) was also cloned, its product found interact with hREV3, but biological function hREV7 remained unknown. We report here...
We developed a simple algorithm, i-Score (inhibitory-Score), to predict active siRNAs by applying linear regression model 2431 siRNAs. Our algorithm is exclusively comprised of nucleotide (nt) preferences at each position, and no other parameters are taken into account. Using validation dataset 419 siRNAs, we found that the prediction accuracy as good those s-Biopredsi, ThermoComposition21 DSIR , which employ neural network or more in model. Reynolds Katoh also efficiently, but numbers...
AbstractThe Ret receptor tyrosine kinase plays a crucial role in the development of enteric nervous system and kidney. Tyrosine 1062 represents binding site for phosphotyrosine-binding domains several adaptor effector proteins that are important activation intracellular signaling pathways, such as RAS/ERK, phosphatidylinositol 3-kinase/AKT, Jun-associated N-terminal pathways. To investigate importance organogenesis vivo, knock-in mice which was replaced with phenylalanine were generated....
Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, large amount of hydrogen produced bacterial catalysis lactulose. We previously reported marked effects ad libitum administration water on prevention rat model Parkinson's disease (PD).End-alveolar breath concentrations were measured 28 healthy subjects 37 PD patients, as well 9 rats after taking or Six-hydroxydopamine (6-OHDA)-induced hemi-PD was stereotactically generated rats....
The Sprouty (SPRY) family of proteins includes important regulators downstream signaling initiated by receptor tyrosine kinases. In the present study, we investigated role SPRY in intracellular via RET kinase activated glial cell line‐derived neurotrophic factor (GDNF). Expression SPRY1, SPRY2, SPRY3 and SPRY4 HEK293T cells transfected with GDNF α1 (GFRα1) genes significantly reduced sustained ERK activation as well ELK‐1 activation. Because expression SPRY2 was efficiently induced TGW human...
Recently, miR-143 and miR-145 have been shown to belong a subset of microRNAs whose expression is controlled by complex tumor suppressor p53 DEAD-box RNA helicase subunits p68/p72. While accumulating studies acknowledged that both miRNAs function as suppressors are similarly regulated, evidence their coordinated action against tumorigenesis has poorly presented. Herein, we establish transgenic mice express under the control CAG regulatory unit. When crossbred with ApcMin/+ mice, development...