A5081263898- Orthopedic Infections and Treatments
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Shoulder and Clavicle Injuries
- Trauma Management and Diagnosis
- Hip and Femur Fractures
- Tendon Structure and Treatment
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Surgery and Rehabilitation
- Pelvic and Acetabular Injuries
- Medical Practices and Rehabilitation
- Infectious Diseases and Tuberculosis
- Sports injuries and prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Lower Extremity Biomechanics and Pathologies
- Spinal Fractures and Fixation Techniques
- Elbow and Forearm Trauma Treatment
- Pregnancy-related medical research
- Surgical site infection prevention
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Bacterial Identification and Susceptibility Testing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University Hospital Münster
2015-2025
Marymount University
2021
University of Münster
2008-2020
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2009-2011
Osteomyelitis is a difficult-to-eradicate bone infection typically caused by Staphylococcus aureus. In this study, we investigated the in vivo transcriptional adaptation of S. aureus during infection. To end, determined transcriptome acute (day 7) and chronic 28) phases experimental murine osteomyelitis using RNA sequencing (RNA-Seq). We identified total 180 genes significantly more highly expressed or than under vitro growth conditions. These encoded proteins involved gluconeogenesis,...
(1) Background: The incidence of fragility fractures the pelvis (FFP) has increased significantly over past decades. Unilateral non-displaced fractures, defined as FFP II, are most common type fracture. When conservative treatment fails, surgical is indicated. We hypothesize that use bilateral SI screws (BSIs) or a transsacral screw (TSI) superior compared to unilateral (USI) because significant reduction in risk adjacent and fracture progression. (2) Methods: A finite element model female...
Acromioclavicular (AC) joint dislocation is a frequent injury in sports.A minimally invasive flip-button technique, MINAR (minimally acromioclavicular reconstruction), will achieve good clinical and radiographic results the surgical treatment of high-grade AC dislocations.Case series; Level evidence, 4.In this study, 96 patients with grades III through V repair were identified. Radiographic assessment was performed by use Alexander view anteroposterior stress radiograph. Clinical outcomes...
Abstract Purpose Severe thorax trauma including multiple rib fractures and flail chest deformity are leading causes of death in patients. Increasing evidence supports the use surgical stabilisation (SSRF) these However, there is currently a paucity for its non-ventilator-dependent Methods A retrospective propensity-matched analysis data TraumaRegister DGU ® patients with severe injury (abbreviated score ≥ 3) was performed. Subgroup analyses respect to severity score, American society...
While Staphylococcus aureus has classically been considered an extracellular pathogen, these bacteria are also capable of being taken up by host cells, including nonprofessional phagocytes such as endothelial epithelial or osteoblasts. The intracellular S. lifestyle contributes to infection development. predominant recognition and internalization pathway appears be the binding via a fibronectin bridge α5β1-integrin on cell membrane, followed phagocytosis. Although osteoblasts showed high...
Aims Biofilm formation is one of the primary reasons for difficulty in treating implant-related infections (IRIs). Focused high-energy extracorporeal shockwave therapy (fhESWT), which a treatment modality fracture nonunions, has been shown to have direct antibacterial effect on planktonic bacteria. The goal present study was investigate fhESWT Staphylococcus aureus biofilms vitro presence and absence antibiotic agents. Methods S. were grown titanium discs (13 mm × 4 mm) bioreactor 48 hours....
The rise of highly resistant bacteria creates a persistent urge to develop new antimicrobial agents. This paper investigates the application lipopeptide antibiotic daptomycin in infections involving human bone.Compressive and tensile strength testing daptomycin-laden PMMA was performed referring ISO 5833. microstructure antibiotic-laden evaluated by scanning electron microscopy. Intracellular activity determined osteoblast infection model. Elution kinetics bone cement measured using...
Abstract Background Long-bone non-unions after intramedullary nailing can be treated by nail dynamization or focused high-energy extracorporal shock wave therapy (fESWT). The objective of this study was to assess the effect combination and fESWT on long-bone non-unions. Materials methods 49 patients with (femur tibia) were (group D, n = 15), S, 17) in addition DS, 17). Patients followed up for 6 months retrospectively. Furthermore, age, sex, Non-Union Scoring System (NUSS) score, time...
In the fields of traumatology and orthopaedics staphylococci are most frequently isolated pathogens. Staphylococcus aureus epidermidis known to be major causative agents osteomyelitis. The increasing number multiresistant resistant coagulase-negative as a trigger complicated osteomyelitis implant-associated infections is problem. Antibiotic therapy fails in 20% cases. Therefore development novel antibiotics becomes necessary. This study analyses tigecyclin, first antibiotic glycylines,...
Purpose: Several suture techniques have been described in the past for direct ACL repair with poor healing capacity and a high re-rupture rate. Therefore, we investigated refixation technique acute primary proximal repair. The purpose of this study is to compare biomechanical properties different configurations using knotless anchor. Methods: In study, 35 fresh-frozen porcine knees underwent refixation. First, 10 femora, anchor, without ligament attached, were tested. Then, three evaluated...