A5046087916- Pancreatic and Hepatic Oncology Research
- Rheumatoid Arthritis Research and Therapies
- Neuroendocrine Tumor Research Advances
- Systemic Lupus Erythematosus Research
- Gastric Cancer Management and Outcomes
- Essential Oils and Antimicrobial Activity
- PI3K/AKT/mTOR signaling in cancer
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Tuberculosis Research and Epidemiology
- Phytochemistry and Biological Activities
- Inflammatory Bowel Disease
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Spondyloarthritis Studies and Treatments
- Lung Cancer Treatments and Mutations
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Pancreatitis Pathology and Treatment
- Chronic Myeloid Leukemia Treatments
- Colorectal Cancer Screening and Detection
- Acute Lymphoblastic Leukemia research
Université Djilali de Sidi Bel Abbès
2014-2023
Institute for Stem Cell Biology and Regenerative Medicine
2017
Hôpital Tenon
2016
Sorbonne Université
2016
University Hospital of Oran
2015
Bipar
2014
Hôpital Saint-François d'Assise
2012
Centre hospitalier universitaire de Québec
2012
Université de Picardie Jules Verne
2005-2008
Inserm
2005-2008
The active forms of STAT5A (signal transducer and activator transcription 5A) STAT5B are able to relieve the cytokine dependence haematopoietic cells induce leukaemia in mice. We have demonstrated previously that activation PI3K (phosphoinositide 3-kinase) signalling cascade plays a major role cell growth survival induced by these proteins. Interaction between STAT5 p85, regulatory subunit PI3K, has been suggested be required for this activation. show present study scaffolding protein Gab2...
Abstract Previous work from our laboratory has shown that human ether à go‐go (hEAG) K + channels are crucial for breast cancer cell proliferation and cycle progression. In this study, we investigated the regulation of hEAG by an insulin‐like growth factor‐1 (IGF‐1), which is known to stimulate proliferation. Acute applications IGF‐1 increased current‐density hyperpolarized MCF‐7 cells. The effects were inhibited inhibitors. Moreover, mRNA expression in a time‐dependent manner parallel with...
Multi-drug resistance (MDR) TB is defined as tuberculosis (TB) disease caused by a strain of Mycobacterium (MTB) that was resistant to at least isoniazid and rifampicin (RIF). Emerging Multidrug-Resistant one the major concerns health policy rapid detection M. RIF in infected patients are essential for management. The aim this study evaluate patterns cases sputum positive pulmonary using GeneXpert MTB/RIF comparing between phenotypic genotypic testing MTB strains clinically suspected MDR-TB...
Endometriosis is often associated with a chronic pelvic immuno-inflammatory process, which closely related to disease pathogenesis and major symptoms. Our studies led the detection of marked imbalance between IL-1 its natural inhibitor receptor type 2 (IL1R2) in women endometriosis. This points deficiency local control that, view cytokine's elevated levels potent proinflammatory, angiogenic, growth-promoting effects, may contribute endometriosis development. Using an vivo model human...
Pancreatic cancer is one of the most challenging tumor entities worldwide, characterized as a highly aggressive disease with dismal overall prognosis and an incidence rate equaling mortality rate.In order to have update about pancreatic evolution in North Africa, we conducted epidemiological analytical retrospective study at level three Algerian regions: Sidi-bel-Abbes, Oran Tlemcen along last eight years [2006-2013].We performed hospital-based which analyzed records 160 patients registered,...
This study aimed to clarify the Ki-67 distribution, p53 expression and their relationship with clinico-pathologic features of gastric B cell lymphoma from Northern African population.Twenty paraffin blocks were retrieved archival materials Department Pathology, Central University Hospital Sidi Bel Abbes (Western Algeria) 2007 2013. Four µm section specimens stained by immunohistochemical (IHC) technique tumor markers. P values <0.05 considered statistically significant.Expression proteins...
Introduction: il s'est agit ici de déterminer la fréquence et les facteurs risques mortalité néonatale au service néonatologie l'Etablissement Hospitalier Spécialisé Gynécologie Obstétrique wilaya Sidi Bel Abbés (Ouest Algérien).
Primary gastrointestinal (GI) lymphomas (GIL) are uncommon diseases that can involve the whole GI tract. Considerable variation exists in literature with respect to incidence of various histological subtypes and sites involvement. This study was undertaken establish anatomic distribution, patients from Western Algeria.The case records 58 consecutive GIL diagnosed at Pathologies Departments Algerian west region (the Military Hospital Oran city Central University Sidi Bel Abbes city) January...
Context Hodgkin's lymphoma is an uncommon disorder with heterogeneous clinical, histological, and epidemiological characteristics.Aims The aim of this study was to describe the histopathological characteristics in patients Western Algeria.Materials methods Our retrospective descriptive conducted at Departments Haematology Algerian hospitals over 11 years (2001–2011).Statistical analysis used SPSS 18.0 used.Results A total 526 were identified our study. There 273 male 253 female patients, a...
Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages laboratory assessment in Algerian patients with Rheumatoid arthritis, as well their importance like a predictive factor for diagnosis arthritis (RA).
 Methods: 281 diagnosed RA according ACR 1987 criteria internal medicine Functional Rehabilitation departments (the University Hospital Sidi...
Bacteria are attracting the interest of worldwide investors; their use is interesting in several industrial fields, this organism produces a wide variety extracellular enzymes, including proteases.The objective study was to evaluate production protease by different bacterial strains isolated from local marine samples collected Cap Rousseau beach Oran city, northwestern Algeria, 44 isolates were tested for cultivating them on skim milk agar medium.The proteolytic activities all using and...
Le cancer du pancréas reste de nos jours le au pronostic plus sombre. C’est un hautement agressif avec taux mortalité égal à celui son incidence. but notre étude était déterminer les caractéristiques épidémiologiques et histo-pronostiques pancréatique niveau des trois grandes régions l’Ouest Algérien. Il s’agit d’une rétrospective descriptive portant sur 160 cas diagnostiqués entre janvier 2006 décembre 2013 services chirurgie d’anatomopathologie CHU Sidi bel Abbes Tlemcen ainsi qu’à...
Les lymphomes digestifs représentent 12,5% de ľensemble des non hodgkiniens (LNH) et sont les plus fréquentes formes extra-ganglionnaires. Le but ce travail était décrire aspects épidémiologiques histo-pronostiques gastro-intestinaux (LGI) à Oran. Il s’agit ďune étude rétrospective descriptive portant sur tous observés une période 7 ans (2006–2012) au niveau du laboratoire ďanatomopathologique CHU ďOran. Au cours notre ďétude nous avons colligé 45 cas LGI avec un âge moyen patients 52,06...
Notre étude avait pour objectif d’effectuer une épidémiologique rétrospective afin de déterminer les caractéristiques histo-cliniques, pathologiques et thérapeutiques des cancers rénaux dans l’Ouest Algérien. Etude incluant 115 cas diagnostiqués au sein services d’oncologie d’anatomopathologie du CHU Sidi Bel Abbes l’Hôpital Militaire Régional Universitaire d’Oran (HMRUO) entre Janvier 2006 Décembre 2013. Il s’agissait 65 hommes 50 femmes. L’âge moyen découverte était 58,54 ans (extrêmes: 20...
We performed a retrospective descriptive analytical study over all preterm birth babies along the period of 2011-2012 at level neonatology department Sidi Bel Abbes city (Western Algeria).Primigravida (OR=7, 95% CI: 3, 16), primiparous (OR=6.23,95% 1.5, 9.5) and mother's age < 25 years (OR=5.8,95% 8.9) were major risk factors premature delivery.Abortion also raised odds (OR=2.1,95% 1.2, 2.56).Twin delivery intra uterine growth marginally significantly associated with (OR=2.15;OR=...
Hepatocellular carcinoma is the most frequent primary liver cancer. Its prognosis very severe. The objectives of this study were to establish epidemiological profile, clinico-pathological for hepatocellular in region Sidi Bel Abbes (west Algeria). To do so, we conducted a retrospective 2005 2014 including 56 cases diagnosed and monitored gastroenterology oncology services university hospital Abdelkader Hassani Abbes. average age our patients was 62.35 years, maximum frequency represented...