A5002298461- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Orthopedic Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Cell Adhesion Molecules Research
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Peptides and Activities
- Oral microbiology and periodontitis research
- Latin American and Latino Studies
- Biochemical and Structural Characterization
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Radio, Podcasts, and Digital Media
- Bacillus and Francisella bacterial research
University of California, Irvine
2022
Jena University Hospital
2014-2019
University of Münster
2013
Staphylococcus aureus is a major human pathogen that causes range of infections from acute invasive to chronic and difficult-to-treat. Infection strategies associated with persisting S. are bacterial host cell invasion the ability dynamically change phenotypes aggressive wild-type small colony variants (SCVs), which adapted for intracellular long-term persistence. The underlying mechanisms switching adaptation appear be very dynamic, but largely unknown. Here, we analyzed role crosstalk...
Staphylococcus aureus osteomyelitis often develops to chronicity despite antimicrobial treatments that have been found be susceptible in vitro tests. The complex infection strategies of S. aureus, including host cell invasion and intracellular persistence via the formation dynamic small colony variant (SCV) phenotypes, could responsible for therapy-refractory courses. To analyse efficacy antibiotics acute chronic stage bone infections, we established long-term vivo models. Antibiotics were...
Staphylococcus aureus is a major pathogen causing bone infections that can become chronic and difficult to treat. Recently, we described the mechanism employed by S. switch small colony variants (SCVs) trigger intracellular bacterial persistence through global stress regulator SigB. Here, studied role of SigB in formation osteomyelitis. We used murine hematogenous osteomyelitis model, where mice were infected via tail vein subsequently developed Mice with LS1, LS1ΔsigB complemented kidney...
The extracellular matrix protein Emp of Staphylococcus aureus is a secreted adhesin that mediates interactions between the bacterial surface and host structures. However, its structure role in staphylococcal pathogenesis remain unknown. Using multidisciplinary approaches, including circular dichroism (CD) Fourier transform infrared (FTIR) spectroscopy, transmission electron (TEM) immunogold microscopy, functional ELISA assays silico techniques, we characterized protein. We demonstrated...
Staphylococcus aureus is a facultative pathogenic bacterium that colonizes the nasopharyngeal area of healthy individuals, but can also induce severe infection, such as pneumonia. Pneumonia caused by mono- or superinfected S.aureus leads to high mortality rates. To establish an S. disposes wide variety virulence factors, which vary between clinical isolates. Our study aimed characterize pneumonia isolates for their virulent capacity. For this, we analyzed from colonization, due aureus, and...
Binding to fibronectin (FN) is a crucial pathogenic factor of Staphylococcus aureus mediated by fibronectin-binding protein A (FnBP-A) and extracellular adherence (Eap). Recently, we have shown that binding soluble CD163 (sCD163) FN linked these molecules exhibits anti-microbial effects enhancing phagocytosis killing activity S. aureus-infected monocytes. However, it remained unclear whether sCD163 also influences the monocytic activation status. Using genetically modified staphylococcal...
Accurate and fast pathogen identification consecutive antimicrobial susceptibility testing (AST) is of vital importance for patient outcome in patients suffering from sepsis. The Accelerate Pheno™ system a new, fully automated, culture-independent diagnostic method both (ID) (AST). We analyzed positive blood cultures critically ill with new onset sepsis according to the guidelines, using conventional standard methods (VITEK, MALDI-TOF) system. ID/AST results were not reported treating...