A5029680202- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Machine Learning in Healthcare
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- COVID-19 diagnosis using AI
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Artificial Intelligence in Healthcare and Education
- Biomedical and Chemical Research
- Family and Patient Care in Intensive Care Units
- Simulation-Based Education in Healthcare
- Reconstructive Surgery and Microvascular Techniques
- Trauma Management and Diagnosis
- COVID-19 and healthcare impacts
- Trauma and Emergency Care Studies
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nosocomial Infections in ICU
- Mobile Health and mHealth Applications
- Radiomics and Machine Learning in Medical Imaging
RWTH Aachen University
2014-2025
Universitätsklinikum Aachen
2012-2024
German Medical Association
2024
Inform (Germany)
2024
Witten/Herdecke University
2024
Jena University Hospital
2024
RELX Group (United States)
2022
Westfälische Hochschule
2021
Ziekenhuis Oost-Limburg
2021
Intensive Care Society
2020
n December 2019, an acute lung disease of unknown origin broke out in the Chinese province Hubei.On 7 January 2020, scientists succeeded isolating a new coronavirus (severe respiratory syndrome corona virus 2, SARS-CoV-2) and identifying it as cause virus-induced pneumonia (1, 2).In line with WHO's definition disease, is now referred to 2019 (COVID-19) and, person-to-person droplet infection, rapidly spreading worldwide (3).The clinical manifestation infection highly variable, ranging from...
Objective The attitudes about the usage of artificial intelligence in healthcare are controversial. Unlike perception professionals, patients and their companions have been less interest so far. In this study, we aimed to investigate among highly relevant group along with influence digital affinity sociodemographic factors. Methods We conducted a cross-sectional study using paper-based questionnaire at German tertiary referral hospital from December 2019 February 2020. consisted three...
Die nicht-invasive Beatmung (NIV) ist in der klinischen Medizin weit verbreitet und hat mittlerweile einen hohen Stellenwert im Alltag erlangt. Der Einsatz NIV reduziert die Intensiv- Krankenhausaufenthaltsdauer sowie Mortalität von Patienten mit akutem hyperkapnischen Atemversagen. akuter respiratorischer Insuffizienz Rahmen eines Lungenödems sollten neben den notwendigen kardiologischen Interventionen CPAP oder behandelt werden. Bei anderen Formen des akuten hypoxämischen Atemversagens...
Abstract The aim of this work was to develop and evaluate the reinforcement learning algorithm VentAI, which is able suggest a dynamically optimized mechanical ventilation regime for critically-ill patients. We built, validated tested its performance on 11,943 events volume-controlled derived from 61,532 distinct ICU admissions it an independent, secondary dataset (200,859 stays; 25,086 events). A patient “data fingerprint” 44 features extracted as multidimensional time series in 4-hour...
Background The increasing development of artificial intelligence (AI) systems in medicine driven by researchers and entrepreneurs goes along with enormous expectations for medical care advancement. AI might change the clinical practice physicians from almost all disciplines most areas health care. While are high, practical implementations still scarce Germany. Moreover, physicians’ requirements their opinion on usage anonymized patient data biomedical research have not been investigated...
Mobile health plays an important role in providing individualized information about the status of patients. Limited exists on intensive care unit (ICU) patients with risk suffering from post-intensive syndrome (PICS), summarizing long-term physical, mental and cognitive impairment. This web-based survey study aims to identify specific needs former ICU for utilizing a newly developed, so called Post-Intensive Care Outcome Surveillance (PICOS) app collect relevant PICS-related parameters. A...
Spontaneous breathing trials (SBTs) on a T-piece can be difficult in patients with prolonged weaning because of remaining de-recruitment phenomena and/or insufficient ventilation. There is no clinically established method existent other than experience for estimating whether an SBT most probably beneficial. Electrical impedance tomography (EIT) clinical useful online monitoring technique during mechanical ventilation, particularly it enables analysis effects regional ventilation...
Intensive Care Resources are heavily utilized during the COVID-19 pandemic. However, risk stratification and prediction of SARS-CoV-2 patient clinical outcomes upon ICU admission remain inadequate. This study aimed to develop a machine learning model, based on retrospective & prospective data, stratify predict survival outcomes.A Germany-wide electronic registry was established pseudonymously collect admission, therapeutic discharge information patients retrospectively prospectively. Machine...
Treatment of patients undergoing prolonged weaning from mechanical ventilation includes repeated spontaneous breathing trials (SBTs) without respiratory support, whose duration must be balanced critically to prevent over- and underload musculature. This study aimed develop a machine learning model predict the unassisted breathing. Structured clinical data specialized unit were used (1) classifier qualitatively an increase duration, (2) regressor quantitatively precise SBTs on next day, (3)...
Aim: To compare a new method of non‐invasive determination cardiac output based on electrical velocimetry (EV‐CO) with invasive thermodilution methods. Methods: Fifty critically ill patients were enrolled into the study. EV‐CO was compared measured by pulmonary artery catheter (PA‐CO) in one group ( n = 25) and femoral (PiCCO‐CO) second 25), simultaneous measurements. Standard electrocardiography electrodes used for measurements, calculated using Bernstein–Osypka equation. The measurements...
Although male Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients have higher Intensive Care Unit (ICU) admission rates and a worse disease course, comprehensive analysis of female ICU survival underlying factors such as comorbidities, risk factors, and/or anti-infection/inflammatory therapy administration is currently lacking. Therefore, we investigated the association between sex survival, adjusting for these other variables. In this multicenter observational cohort...
Survivors of acute respiratory distress syndrome exhibit neuropsychological sequelae that might be attributable to hippocampal damage. The authors sought determine the effects hypoxemia in a pig model lung injury on region and release S-100 protein comparison control group which was induced by reducing inspired oxygen fraction.Hypoxemia 14 female pigs repeated lavages (lung group; n = 7) or fraction (hypoxia-only 7). Hemodynamic variables, gas exchange, serum concentrations were measured at...
To determine the effects of norepinephrine and levosimendan on microvascular perfusion oxygenation in a rat model septic shock.Controlled laboratory animal study.Research university hospital.Forty Sprague-Dawley rats.Sepsis was induced 32 animals by cecal ligation puncture. Eight served as sham controls. Animals were randomly assigned to five groups: 1) fluid resuscitation (25 ml x kg(-1) h(-1)), 2) plus (0.5 microg min(-1)), 3) (0.3 4) no treatment 5) control.Microvascular quantitated using...
In study, we investigated the effects of different tidal volumes on cerebral tissue oxygenation and metabolism in a porcine model acute lung injury (ALI). We hypothesized that mechanical ventilation with low (LT) improves after experimentally induced ALI.After inducing experimental ALI by surfactant depletion, studied two conditions 10 female pigs: 1) LT volume 6 mL/kg body weight, 2) high (HT) 12 weight. Variables gas exchange, hemodynamic, continuous oxygen tension (p(ti)O2),...
The use of mobile devices in hospital care constantly increases. However, smartphones and tablets have not yet widely become official working equipment medical care. Meanwhile, the parallel private hospitals is common. Medical staff a growing number ways. This mixture how they can be used challenge to persons charge defining strategies rules for usage care.Therefore, we aimed examine status quo physicians' device concrete requirements their future expectations used.We performed web-based...
20% of patients with mechanical ventilation (MV) have a prolonged, complex weaning process, often experiencing condition ICU-acquired weakness (ICUAW), severe decrease in muscle function and restricted long-term prognosis. We aimed to analyze protocolized, systematic approach physiotherapy prolonged hypothesized that the duration from MV would be shortened. ICU were included before (group 1) after 2) introduction quality control measure structured protocolized program. Primary endpoint was...
Abstract Introduction There is evidence that use of automated external defibrillators (AEDs) by laypersons improves rates survival from cardiac arrest, but there no consensus on the optimal content and duration training for this purpose. In study we examined semiautomatic or automatic AEDs who had received (intuitive use) effects minimal general theoretical instructions their performance. Methods a mock arrest scenario, 236 first year medical students not previously attended any preclinical...