A5051877020- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Parathyroid Disorders and Treatments
- Cardiac Structural Anomalies and Repair
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- Connective tissue disorders research
- Trauma and Emergency Care Studies
- Climate Change and Health Impacts
- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Trauma Management and Diagnosis
- Cardiovascular Effects of Exercise
- Frailty in Older Adults
- Aortic Disease and Treatment Approaches
- Healthcare Technology and Patient Monitoring
- Vitamin K Research Studies
- Cardiac electrophysiology and arrhythmias
St.-Johannes-Hospital Dortmund
2023-2025
RWTH Aachen University
2013-2024
Universitätsklinikum Aachen
2006-2024
Massachusetts General Hospital
2011-2015
Harvard University
2011-2015
Acceleron Pharma (United States)
2012
The expression of bone morphogenetic proteins (BMPs) is enhanced in human atherosclerotic and calcific vascular lesions. Although genetic gain- loss-of-function experiments mice have supported a causal role BMP signaling atherosclerosis calcification, it remains uncertain whether might be targeted pharmacologically to ameliorate both these processes.We tested the impact pharmacological inhibition on calcification LDL receptor-deficient (LDLR-/-) mice. LDLR-/- fed high-fat diet developed...
Objective Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic (BMP) signal transduction. MGP deficiency associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation vascular smooth muscle cells (VSMCs) and mesenchymal transition endothelial (EndMT). In this study, we investigated contribution BMP transduction develops MGP-deficient mice. Approach Results mice (MGP-/-) were treated one two signaling inhibitors,...
Objective: Despite the introduction of mild therapeutic hypothermia into postcardiac arrest care, cerebral and myocardial injuries represent limiting factors for survival after cardiac arrest. Administering xenon may confer an additional neuroprotective effect successful cardiopulmonary resuscitation due to its ability stabilize cellular calcium homeostasis via N-methyl-D-aspartate-receptor antagonism. Design: In a porcine model, we evaluated effects treatment in addition on neuropathologic...
Although inhalation of 80 parts per million (ppm) hydrogen sulfide (H2S) reduces metabolism in mice, doses higher than 200 ppm H2S were required to depress rats. We therefore hypothesized that concentrations are reduce larger mammals and humans. To avoid the potential pulmonary toxicity at high concentrations, we investigated whether administering via ventilation an extracorporeal membrane lung (ECML) would provide means manipulate metabolic rate sheep. A partial venoarterial cardiopulmonary...
Abstract Introduction The probability to achieve a return of spontaneous circulation (ROSC) after cardiac arrest can be improved by optimizing during cardiopulomonary resuscitation using percutaneous left ventricular assist device (iCPR). Inhaled nitric oxide may facilitate transpulmonary blood flow iCPR and therefore improve organ perfusion outcome. Methods Ventricular fibrillation was electrically induced in 20 anesthetized male pigs. Animals were untreated for 10 minutes before attempted....
Inhaled nitric oxide (iNO) improves outcomes when given post systemic ischemia/reperfusion injury. iNO during cardiopulmonary resuscitation (CPR) may therefore improve return of spontaneous circulation (ROSC) rates and functional outcome after cardiac arrest (CA).Thirty male Sprague-Dawley rats were subjected to 10 minutes CA at least 3 CPR. Animals randomized receive either 0 (n = 10, Control), 20 ppm), or 40 ppm) ppm CPR until 30 ROSC. A neurological deficit score was assessed daily for...
Knowledge about the influence of current neuroprotective interventions on prognostic markers after survival from cardiac arrest is lacking. This study aimed to investigate effects mild therapeutic hypothermia release astroglial protein S-100 cardiopulmonary resuscitation (CPR) in survivors out-of-hospital arrest. was a prospective, observational performed during two-year period, involving medical emergency services and five collaborating hospitals at city Aachen, Germany. Sixty-eight...
Treatment options to improve resuscitability and neurological prognosis after cardiac arrest (CA) are limited. Hydrogen sulfide has demonstrated remarkable improvements in outcomes small animal models of severe hypoxia or hemorrhage. We investigated the influence sodium (Na2S), a liquid hydrogen donor, on resuscitability, postresuscitation hemodynamics, performance porcine model prolonged CA cardiopulmonary resuscitation. Twenty-four male pigs were instrumented with arterial pulmonary artery...
BACKGROUND During the surge in coronavirus disease 2019 (COVID-19) infections early 2020, many medical organisations began developing strategies for implementing teleconsultation to maintain services during lockdown and limit physical contact. Therefore, we developed a preoperative evaluation platform replace on-site meetings. OBJECTIVE This study assessed feasibility of procedure-associated adverse events. DESIGN Implementation study. SETTING A tertiary care university hospital Germany from...
Introduction:Teleconsultations for preoperative evaluation in anesthesiology proved to be feasible during the COVID-19 pandemic. However, widespread implementation of teleconsultations has not yet occurred. Besides time savings and economic benefits, anesthesia may have potential reduce CO2 emissions.Methods:We conducted a life cycle assessment based on prospective surveys assess environmental benefits comparison status-quo in-person consultations. Within 1 month, all patients presenting at...
Abstract Introduction There is evidence that use of automated external defibrillators (AEDs) by laypersons improves rates survival from cardiac arrest, but there no consensus on the optimal content and duration training for this purpose. In study we examined semiautomatic or automatic AEDs who had received (intuitive use) effects minimal general theoretical instructions their performance. Methods a mock arrest scenario, 236 first year medical students not previously attended any preclinical...
Abstract Introduction Despite improvements in pre-hospital and post-arrest critical care, sudden cardiac arrest (CA) remains one of the leading causes death. Improving circulation during cardiopulmonary resuscitation (CPR) may improve survival rates long-term clinical outcomes after CA. Methods In a porcine model, we compared standard CPR (sCPR; n =10) with using an intravascular assist device without additional chest compressions (iCPR; following 10 minutes electrically induced ventricular...
Cardiovascular disease is the leading cause of morbidity and mortality in world. Atherosclerotic plaques, consisting lipid-laden macrophages calcification, develop coronary arteries, aortic valve, aorta, peripheral conduit arteries are hallmark cardiovascular disease. In humans, imaging with computed tomography allows for quantification vascular calcification; presence calcification a strong predictor future events. Development novel therapies relies critically on improving our understanding...
This study aimed to determine standard left (LV) and right ventricular (RV) transesophageal echocardiographic (TEE) measurements in swine. Additionally, global myocardial work index (GWI) was estimated using pressure-strain loops (PSL). A comprehensive TEE examination conducted ten anesthetized, intubated mechanically ventilated healthy female German landrace swine, weighing 44 57 kg. For GWI calculation, we performed LV RV segmental strain analysis used invasively measured pressure obtain...