A5022715596- Voice and Speech Disorders
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Speech Recognition and Synthesis
- Dysphagia Assessment and Management
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Phonetics and Phonology Research
- Vascular Anomalies and Treatments
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Noise Effects and Management
- Obstructive Sleep Apnea Research
- Hearing Loss and Rehabilitation
- COVID-19 and healthcare impacts
- Speech and Audio Processing
- Infection Control and Ventilation
- Vascular Malformations and Hemangiomas
- Soft Robotics and Applications
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Facial Nerve Paralysis Treatment and Research
University Hospital Regensburg
2017-2025
Loma Linda University Medical Center
2025
Loma Linda University
2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2020-2024
University of Regensburg
2018-2023
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2021-2023
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2019-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2005-2020
Universitätsklinikum Erlangen
2010-2018
Abstract Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer the oral epithelium. Despite their high impact on mortality, sufficient screening methods for early diagnosis OSCC often lack accuracy and thus OSCCs are mostly diagnosed at late stage. Early detection accurate outline estimation would lead to better curative outcome reduction in recurrence rates after surgical treatment. Confocal Laser Endomicroscopy (CLE) records sub-surface micro-anatomical images vivo cell structure...
SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk nosocomial infections SARS-CoV-2. In this context, preprocedural mouthrinses hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim study was to investigate effects a 1% mouthrinse on reducing load.Twelve out 98 initially screened hospitalized SARS-CoV-2-positive patients were included...
Purpose High-speed videoendoscopy (HSV) is an emerging, but barely used, endoscopy technique in the clinic to assess and diagnose voice disorders because of lack dedicated software analyze data. HSV allows quantify vocal fold oscillations by segmenting glottal area. This challenging task has been tackled various studies; however, proposed approaches are mostly limited not suitable for daily clinical routine. Method We developed a user-friendly C# that editing, motion correction,...
Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function antitumor immunity. Interestingly, expression of the transporter monocarboxylate (MCT) 4, but not MCT1, turned out to be prognostic for survival patients with rectal cancer, indicating that single MCT4 blockade might a promising strategy overcome glycolysis-related therapy resistance. Methods To determine whether alone is sufficient improve efficacy immune checkpoint (ICB) therapy, we examined effects...
Background Current standard treatment concepts in head and neck squamous cell carcinoma (HNSCC) are based on former studies using 2D 3D plans. However, modern radiation techniques allow for a more precise individual dose application. Therefore, clearly defined patient population, de-intensified risk-adapted is investigated. Methods Patients with newly diagnosed HNSCC after surgery (with resection margins ≥1 mm cM0) the following tumor stages (TNM 7th Edition) were eligible study: oral...
Abstract Background With the development of imaging techniques in diagnostics head and neck carcinomas, especially computed tomography ultrasonogaphy, one might expect that incidence occult metastases would be reduced. The aim this study was to determine rate a large population cohort explore its changes with improvement over last 30 years. Methods All patients between 1980 2010 carcinoma cN0 status were retrospectively evaluated. Six hundred thirty‐six who received an elective dissection as...
The lung constantly interacts with numerous pathogens. Thus, complex local immune defence mechanisms are essential to recognise and dispose of these intruders. This work describes the detection, characterisation three-dimensional structure a novel protein (surfactant-associated 3 (SFTA3/SP-H)) putative immunological features. Bioinformatics, biochemical methods were combined elucidate function SFTA3. tissue-specific detection was performed by using electron microscopy as well fluorescence...
Ex vivo larynx experiments are limited in time due to degeneration of the laryngeal tissues. In order acquire a significant and comparable amount data, automatization current manual experimental procedures is desirable. A computer controlled, electro-mechanical setup was developed for time-dependent variation specific physiological parameters, including adduction elongation level vocal folds glottal flow. The offers standardized method induce defined forces on cartilages. Furthermore,...
Metabolic pathways regulate immune responses and disrupted metabolism leads to dysfunction disease. Coronavirus disease 2019 (COVID-19) is driven by imbalanced responses, yet the role of immunometabolism in COVID-19 pathogenesis remains unclear. By investigating 87 patients with confirmed SARS-CoV-2 infection, 6 critically ill non–COVID-19 patients, 47 uninfected controls, we found an immunometabolic dysregulation progressed COVID-19. Specifically, T cells, monocytes, granulocytes exhibited...
Olfactory and gustatory disorders are prominent symptoms of acute COVID-19. Although both senses recover in many patients within weeks to months, persistency has been described up 60%. However now most reports on the course chemosensitive after COVID-19 not based psychophysical testing but only subjective patients’ ratings. In this study we assessed olfaction gustation using tests eight months Validated revealed hyposmia 18% hypogeusia even 32% 303 included patients. This shows that...
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and prone to complications such pain, bleeding, relentless growth, high volume of shunted blood. Due the vascular pressure endothelial cells AVMs exposed mechanical stress. To control symptoms lesion growth pharmacological treatment strategies urgently needed in addition surgery interventional radiology. AVM were isolated from three patients cyclic stretching for 24 h. Thalidomide bevacizumab, both VEGF inhibitors,...
The inferior colliculus is a key nucleus in the central auditory pathway, integrating acoustic stimuli from both cochleae and playing crucial role sound localization. It undergoes functional structural development childhood experiences age-related degeneration later life, contributing to progression of hearing loss. This study aims at finding out, whether volume human can be determined by analysis routinely performed MRIs there any variation. A further goal detect correlations between...
Background: In very advanced tongue cancer, definite radiochemotherapy (RCHT) is often preferred over total or near glossectomy due to organ preservation and functionality, particularly swallowing. Methods: This retrospective study compares the functionality survival of 10 patients with cancer who received (sub)total prior adjuvant RCHT reconstruction by a musculocutaneous anterolateral thigh flap. All had comparable carcinomas treated RCHT. Airway protection swallow efficiency were...
The sentinel lymph node (SLN) is the first (LN) in lymphatic drainage area of a tumor and therefore potentially metastatically altered LN. Various methods are currently used to determine SLN. standard usually lymphoscintigraphy, based on application technetium-99m-labelled [99mTc] radiotracers (Mahieu R. et al. Cancers. 2020; 12(10): 3055). CEUS lymphography (CEUS-SLN) offers an innovative approach sonographically assisted identification This technique peritumoral ultrasound contrast agent...
Background/Objectives: Bleomycin electrosclerotherapy (BEST), which combines intralesional bleomycin administration with electroporation, enhances drug uptake and has shown efficacy in treating vascular malformations resistant to conventional therapies. While BEST is increasingly used various anatomical sites, its application the upper aerodigestive tract remains underexplored. This study evaluates safety effectiveness of managing slow-flow oral cavity, tongue, larynx, hypopharynx. Methods:...
Bell´s palsy is the most common cause of facial paralysis worldwide and disorder cranial nerves. It a diagnosis exclusion, accounting for 60-75% all acquired peripheral nerve palsies. Our case shows first microcystic adnexal carcinoma-like squamous cell carcinoma as palsy.The patient, 70-year-old Caucasian male, experienced subsequent functional impairment trigeminal glossopharyngeal about 1½ years after refractory palsy. An extensive clinical work-up tissue biopsy surrounding parotid gland...
The aim of this study was to identify parameters that would differentiate healthy from pathological organic-based vocal fold vibrations emphasize clinical usefulness high-speed imaging.Fifty-five men (M age = 36 years, SD 20 years) were examined and separated into 4 groups: 1 (26 individuals) 3 (10 individuals with contact granuloma, 12 polyps, 7 cysts). Vocal recorded using a camera during sustained phonation. Twenty objective glottal area waveform 24 phonovibrogram representing...