A5000113361- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Tracheal and airway disorders
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Cancer survivorship and care
- Dysphagia Assessment and Management
- Oral Health Pathology and Treatment
- Oral health in cancer treatment
- PI3K/AKT/mTOR signaling in cancer
- Oral and Maxillofacial Pathology
- Tumors and Oncological Cases
- Cleft Lip and Palate Research
- Reconstructive Facial Surgery Techniques
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Voice and Speech Disorders
- Lung Cancer Research Studies
- Patient-Provider Communication in Healthcare
- Sphingolipid Metabolism and Signaling
St. Louis Children's Hospital
2025
Sarah Cannon
2022-2024
Medical University of South Carolina
2014-2023
MUSC Hollings Cancer Center
2011-2022
Avenue Day Hospital
2015
Charleston Hematology Oncology Associates
2010
Ralph H. Johnson VA Medical Center
2007
College of Charleston
2004-2005
University of Tennessee Medical Center
2005
University of Tennessee at Knoxville
2005
To determine the role of treatment modality in swallowing outcome after head and neck cancer to identify potential risk factors for posttreatment dysphagia.Cross-sectional survey patients with no evidence disease 12 months or more a stage III IV squamous cell carcinoma oropharynx, larynx, hypopharynx.Potential subjects were stratified by tumor site T-stage achieve balanced comparison between chemoradiation (n = 18) surgery/radiation 22) groups. Outcome measures included dysphagia factor...
In this study, endogenous long chain ceramides were measured in 32 human head and neck squamous cell carcinoma (HNSCC) 10 nonsquamous tumor tissues, as compared with adjacent noncancerous by liquid chromatography/mass spectroscopy. Interestingly, only one specific ceramide, C18:0-ceramide, was selectively down-regulated the majority of HNSCC tissues. On other hand, selectivity for C18-ceramide not detected. These data suggested hypotheses that decreased levels C -ceramide might impart a...
Current prognostic criteria are insufficient in predicting outcomes head and neck cancer, necessitating new, readily available biomarkers.Pretreatment neutrophil lymphocyte counts their ratio (NLR) were retrospectively investigated for correlation with overall survival while controlling demographic clinical confounders.Patients the highest tertile of those lowest lymphocytes experienced shorter than rest population. Patients NLR at a higher risk compared after multivariate analysis (hazard...
The objective of this study was to determine the effects National Comprehensive Cancer Network (NCCN) guideline-adherent initiation postoperative radiation therapy (PORT) and different time-to-PORT intervals on overall survival (OS) patients with head neck squamous cell carcinoma (HNSCC).The Data Base reviewed for period 2006-2014, HNSCC undergoing surgery PORT were identified. Kaplan-Meier estimates, Cox regression analysis, propensity score matching used initiating within 6 weeks...
IMPORTANCE This study addresses the most common initial symptoms of oropharyngeal squamous cell carcinoma (OPSCC) and investigates differences between human papillomavirus (HPV)–positive vs HPV-negative tumors. OBJECTIVES To analyze in patients with OPSCC to determine if any occur HPV-positive DESIGN, SETTING, AND PATIENTS Retrospective single-institution review medical records previously untreated diagnosed from January 1, 2008, toMay 20, 2013, who were evaluated by 1 physician (the senior...
BACKGROUND Adherence to evidence‐based treatment guidelines has been proposed as a measure of cancer care quality. The objective this study was determine the rate and predictors that does not adhere National Comprehensive Cancer Network regarding commencing postoperative radiation therapy (PORT) within 6 weeks surgery for patients with head neck squamous cell carcinoma (HNSCC). METHODS Data Base reviewed from 2006 2014, HNSCC who underwent curative‐intent followed by PORT were identified....
(1) To identify predictors of nodal disease in parotid malignancies using various clinical and pathologic variables. (2) examine the effect on overall survival (OS) cancersRetrospective database review.National Cancer Data Base (1998-2012).We identified all cases primary United States between 1998 2012 National Base. Eight histopathologies, constituting >80% cases, were examined for metastasis survival.We 22,653 cancer. major histologies studied, with mucoepidermoid carcinoma (31%), acinic...
The COVID-19 pandemic has resulted in the implementation of rapidly changing protocols and guidelines related to indications perioperative precautions for tracheostomy. purpose this study was evaluate current tracheostomy during provide a framework health systems prepare as science evolves over upcoming months years.
Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic cancer. However, whether antitumor responses could be fostered by neoadjuvant presurgical immunotherapy remains unclear. Using Simon's two-stage design, we present results single-arm phase-II trial where 12 patients stage II-IVA OCSCC received 3 to 4 biweekly doses mg/kg nivolumab...
Abstract Purpose: We studied the impact of mTOR signaling inhibition with rapamycin in head and neck squamous cell carcinoma (HNSCC) neoadjuvant setting. The goals were to evaluate pathway as a therapeutic target for patients advanced HNSCC, clinical safety, antitumor, molecular activity administration on HNSCC. Patients Methods: untreated stage II–IVA HNSCC received 21 days (day 1, 15 mg; 2–12, 5 mg) prior definitive treatment surgery or chemoradiation. Treatment responses assessed...
Head and neck cancer (HNC) is responsible for substantial morbidity, mortality, cost in the United States. Early detection lifestyle risk factors associated with HNC, both determinants of disease burden outcomes, are interrelated public knowledge this disease. Understanding current HNC lacking.To assess awareness among US adults.Online survey 2126 randomly selected adults States conducted 2013.Online administration.Subjective objective assessment including symptoms, factors, association...
Approximately 50% of head and neck cancer survivors experience dysphagia related morbidity. Intensity-modulated radiation therapy (IMRT) is increasingly used to treat oropharyngeal cancers with excellent oncologic outcomes, but few studies have compared it conventional 3-dimensional conformal (3D-CRT) determine whether can decrease treatment-related toxic adverse effects.To IMRT improves percutaneous endoscopic gastrostomy (PEG) tube toxicity outcomes 3D-CRT in patients squamous cell...
Head and neck squamous cell carcinoma (HNSCC) mortality rates have not shown significant reduction in decades. Platelets are being implicated having cancer-promoting roles, an observation supported by the adverse outcomes associated with thrombocytosis many malignancies thrombocytosis. However, prognostic significance of platelet counts HNSCC is unknown. Here, we comprehensively investigate predictive value at diagnosis post-diagnosis antiplatelet treatment overall survival patients.The...