A5078278852- Peripheral Neuropathies and Disorders
- Head and Neck Cancer Studies
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Head and Neck Surgical Oncology
- Stroke Rehabilitation and Recovery
- Vasculitis and related conditions
- Acute Ischemic Stroke Management
- Prion Diseases and Protein Misfolding
- Nasal Surgery and Airway Studies
- Venous Thromboembolism Diagnosis and Management
- Autoimmune Neurological Disorders and Treatments
- Facial Rejuvenation and Surgery Techniques
- Herpesvirus Infections and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- RNA regulation and disease
- Myasthenia Gravis and Thymoma
- Sinusitis and nasal conditions
- Viral Infections and Vectors
- Cerebral Venous Sinus Thrombosis
- Cancer Cells and Metastasis
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Sarcoidosis and Beryllium Toxicity Research
- Alcoholism and Thiamine Deficiency
Klinikum rechts der Isar
2018-2024
Technical University of Munich
2018-2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2024
Krankenhaus Nordwest
2013-2023
Asklepios
2023
Katharinenhospital
2022
Ludwig-Maximilians-Universität München
2016-2018
Universiti Brunei Darussalam
2016
Heidelberg University
2004-2015
University Hospital Magdeburg
2014
Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) recurrent optic neuritis (rON). However, AQP4-Ab found also co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) Sjögren’s syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation. Objectives: In this study, we aimed at evaluating...
Chemo-radiation currently serves as first-line therapy of advanced and recurrent head neck cancer, while new chemotherapy regimens are emerging. However, response rates to any treatment difficult predict underlie broad variation. This study shows the development a standardized, high-throughput in vitro assay assess patients' individual future tool for personalized tumor therapy.Viability proliferation analyses after chemo +/- radiation single spheroids (low adhesion plates/Hanging Drop (HD))...
Takayasu arteritis is well known as a cause of stroke in Asia but has rarely been described the Western world. Here we report clinical and neuroimaging follow-up series patients with from Europe.Seventeen consecutive who fulfilled diagnostic criteria for American College Rheumatology were evaluated on by standardized neurological examination, sonography MRI.At almost 20 yr after onset symptoms, subclavian artery common carotid often affected. In addition, evidence intracranial pathology was...
Objective Cerebral venous thrombosis (CVT) caused by vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus‐based severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccines. In March 2021, after autoimmune pathogenesis VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non‐heparin anticoagulants, and avoidance platelet transfusion. The aim this study to evaluate adherence these its association...
Epstein-Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Recent reports proposed an increased EBV-targeted humoral immune response MS, which appears to be more pronounced pediatric patients. However, little is known about CNS-derived antibody production against EBV patients with MS. The objective this study was assess frequency and intensity intrathecal as compared other neurotropic viruses adult onset In cohorts 43 childhood, 50 MS patients, 20 children...
Abstract Introduction Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, drug that inhibits viral replication. Despite antiviral treatment, mortality around 20% and majority survivors suffer from severe disability. Experimental research recent retrospective observations suggest favourable response to adjuvant dexamethasone. Currently there no randomized trial evidence, however, support the...
Neurologic symptoms rarely occur as presenting feature of systemic lupus erythematosus (SLE). We describe a 37-year old woman who presented with several episodes transverse myelitis and optic neuritis. Clinical, radiologic laboratory findings were compatible neuromyelitis optica (NMO). Seven years after disease onset clinical diagnostic for SLE. This case illustrates that NMO may represent first manifestation SLE many years.
Endoscopic resection of sinonasal cancer has become an alternative to open craniofacial surgery and leads safe satisfying results in emerging numbers. Randomized study data comparing outcomes between approaches are missing. Hence, it remains unclear which subgroups patients might profit most from each technique. We aimed identify such patient tumor characteristics gather information for future prospective design.Case series with chart review.Tertiary academic center.This is based on a...
The purpose of this study was to describe the visual prognosis as well frequency and clinical severity central nervous system involvement in all acute posterior multifocal placoid pigment epitheliopathy (APMPPE) patients one centre.A retrospective database review a prospective clinical, ophthalmological neurological follow-up, if possible, were conducted.Eighteen with APMPPE included mean follow-up 17.1 months. Thirteen participated exam. Visual acuity improved 9 18 0.17 log minimum angle...
Patients with myasthenia gravis (MG) are potentially prone for a severe COVID-19 course, but there limited real-world data available on the risk associated patients MG. Here, we investigate whether current immunosuppressive therapy (IST) influences of SARS-CoV-2 infection and severity.Data from German registry were analyzed May 2020 until June 2021 included patient demographics, MG disease duration, comorbidities, IST use, characteristics, outcomes. Propensity score matching was employed to...
Plasma fibronectin is a circulating protein that facilitates phagocytosis by connecting bacteria to immune cells. A isoform, which includes sequence of 90 AA called extra-domain B (EDB), synthesized de novo at the messenger RNA (mRNA) level in cells, but reason for its expression remains elusive. We detected an 80-fold increase EDB-containing cerebrospinal fluid patients with bacterial meningitis was most pronounced staphylococcal infections. role this isoform further suggested enhanced EDB...
Comorbidity and anemia strongly influence treatment outcome of oropharyngeal squamous cell carcinomas (SCCs), but respective data are frequently lacking in clinical studies. We evaluated 149 cases SCC primarily treated with surgery regarding the impact these factors on disease-free survival (DFS) overall (OS).Data were recorded during follow-up visits. Human papillomavirus (HPV) association was detected by p16 immunohistochemistry.Patients p16-positive disease significantly less comorbid...
Cerebrospinal fluid (CSF) pattern in patients with neuropathologically diagnosed Creutzfeldt-Jakob disease was analyzed.Routine tests included white blood cells count, protein, albumin, immunoglobulins and the presence of oligoclonal immunoglobulin G (IgG) CSF as well calculation intrathecal synthesis by standard methods. In addition, antibodies against neurotropic viruses such measles, rubella, varicella zoster herpes simplex were measured specific antibody index calculated.A blood-CSF...
Basaloid-squamous-carcinomas (BSCC) have been considered as aggressive variants of common squamous-cell-carcinomas (HNSCC). Recent studies demonstrated a different clinical course depending on the tumour site. The aim study is to analyze histopathologic/clinical features BSCC/HNSCC resolved by HPV-status.We analysed BSCC (n=59) and HNSCC (n=981), subdivided due HPV status. Differences were using Chi square, Fisher exact, student's t-test. Survival rates calculated Kaplan-Meier log-rank test....