A5035404648- Evaluation and Performance Assessment
- Educational Assessment and Improvement
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Public Policy and Administration Research
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Human Resource Development and Performance Evaluation
- Neurotransmitter Receptor Influence on Behavior
- Teacher Education and Leadership Studies
- Education Systems and Policy
- Attention Deficit Hyperactivity Disorder
- Nicotinic Acetylcholine Receptors Study
- Mindfulness and Compassion Interventions
- Olfactory and Sensory Function Studies
- Diverse Educational Innovations Studies
- Memory and Neural Mechanisms
- Health Policy Implementation Science
- Community Health and Development
- Advanced Neuroimaging Techniques and Applications
- Adipose Tissue and Metabolism
- Musculoskeletal pain and rehabilitation
- Complex Systems and Decision Making
University of Massachusetts Chan Medical School
2013-2024
Worcester Polytechnic Institute
2019-2024
New York University
1985-2024
Minnesota Department of Education
1993-2023
University of Minnesota System
2009-2023
University of Minnesota
2011-2022
Cognitive Neuroimaging Lab
2003-2015
University of Massachusetts Amherst
1999-2014
Cancer Research UK
1994-2012
The Honourable Society of Lincoln's Inn
2006
Axonal degeneration is a critical, early event in many acute and chronic neurological disorders. It has been consistently observed after traumatic brain injury, but whether axon driver of injury remains unclear. Molecular pathways underlying the pathology have not defined, there no efficacious treatment for injury. Here we show that mice lacking mouse Toll receptor adaptor Sarm1 (sterile α/Armadillo/Toll-Interleukin homology domain protein) gene, key mediator Wallerian degeneration,...
Anesthetics, widely used in magnetic resonance imaging (MRI) studies to avoid movement artifacts, could have profound effects on cerebral blood flow (CBF) and cerebrovascular coupling relative the awake condition. Quantitative CBF tissue oxygenation (blood oxygen level–dependent [BOLD]) were measured, using continuous arterial-spin-labeling technique with echo-planar-imaging acquisition, anesthetized (2% isoflurane) rats under basal hypercapnic conditions. All gases within physiologic...
This paper reviews empirical research on the use of evaluation from 1986 to 2005 using Cousins and Leithwood’s framework for categorizing studies conducted since that time. The literature review located 41 between met minimum quality standards. Leithwood allowed a comparison over After initially grouping these according two categories twelve characteristics, one additional category new characteristic were added their framework. is stakeholder involvement, evaluator competence (under...
This article presents a comprehensive taxonomy of essential competencies for program evaluators. First, the authors provide rationale developing evaluator competencies, along with brief history initial development and validation in King, Stevahn, Ghere, Minnema (2001). Second, they present revised version that describe revision process. Third, crosswalk accompanying indicates which address standards, principles, skills endorsed by major evaluation associations North America. Finally,...
Intrinsic connectional architecture of the brain is a crucial element in understanding governing principle organization. To date, enormous effort has been focused on addressing this issue humans by combining resting-state functional magnetic resonance imaging (rsfMRI) with other techniques. However, research area significantly underexplored animals, perhaps because confounding effects anesthetic agents used most animal experiments connectivity. bridge gap, we have systematically investigated...
The neural mechanism of unconsciousness has been a major unsolved question in neuroscience despite its vital role brain states like coma and anesthesia. existing literature suggests that connections, information integration, conscious are closely related. Indeed, alterations several important circuitries networks during unconscious conditions have reported. However, how the whole-brain network is topologically reorganized to support different patterns transfer remains unknown. Here we...
Abstract Post‐traumatic stress disorder (PTSD) is a mental health precipitated by stressful event that produces fear or terror in the individual. studies, particularly early sexual abuse, have been associated with neuroendocrine dysfunction, most notably hypothalamic–pituitary–adrenal (HPA) axis. Since literature on PTSD and factors young subjects has sparse, present studies were designed to look at basal functioning of HPA axis response abuse girls aged 5 7 years. Morning salivary samples...
The second article in this series on the history of evaluation use has three sections. first and longest develops a functional definition term use, noting that thorough includes initial stimulus (i.e., findings or process), user, way people information, aspect program considered, purpose. It then defines use’s unethical companion, misuse, detailing distinction between two. section briefly discusses broadened concept impact expands to include influence. Finally, third summarizes factors...
The first article in this series traces the initial development of concept evaluation use. As a field, has always paid attention to potential for use, both decision-making and changing people’s thinking. broad history field as we know it today stemmed from two streams: one focused on tests measurement, primarily education, second social research methods, concerning knowledge utilization. Evaluation use had its roots streams, resulting three categories discussing findings: instrumental...
Canavan disease (CD) is a debilitating and lethal leukodystrophy caused by mutations in the aspartoacylase (
Changes in cortical activity during foot shock were assessed under conscious and propofol-anesthetized conditions using functional magnetic resonance imaging (fMRI). Increases signal intensity observed the contralateral somatosensory cortex response to electrical of hindpaw both conditions. These increases ranged from 6% 26% while awake 1% propofol anesthesia. In each six animals studied, largest increase blood oxygenation level-dependent (BOLD)-based was consciousness. three animals,...
To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels and motivation.Male lightly anesthetized, secured in a head body restrainer built-in birdcage resonator positioned 9.4-Tesla spectrometer. When conscious, presented the novel receptive female or an ovariectomized monkey. Both imaging trial was counterbalanced. Significant changes both positive negative BOLD signal mapped...