A5065093490- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Venous Sinus Thrombosis
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Clinical Reasoning and Diagnostic Skills
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Neurological Disorders and Treatments
- Healthcare cost, quality, practices
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Emergency and Acute Care Studies
- Blood Coagulation and Thrombosis Mechanisms
- Healthcare Systems and Practices
- Blood Pressure and Hypertension Studies
- Long-Term Effects of COVID-19
- Radiology practices and education
- Herpesvirus Infections and Treatments
Cornell University
2017-2025
MIND Research Institute
2017-2025
Weill Cornell Medicine
2017-2025
Presbyterian Hospital
2024-2025
Arcadia
2024
Albert Einstein College of Medicine
2017-2022
Montefiore Medical Center
2017-2022
University of Chicago
2022
Brown University
2022
University of Alabama at Birmingham
2022
A small randomized controlled trial suggested that dabigatran may be as effective warfarin in the treatment of cerebral venous thrombosis (CVT). We aimed to compare direct oral anticoagulants (DOACs) a real-world CVT cohort. This multicenter international retrospective study (United States, Europe, New Zealand) included consecutive patients with treated anticoagulation from January 2015 December 2020. abstracted demographics and risk factors, hypercoagulable labs, baseline imaging data,...
Background The public health burden associated with diagnostic errors is likely enormous, some estimates suggesting millions of individuals are harmed each year in the USA, and presumably many more worldwide. According to US National Academy Medicine, improving diagnosis healthcare now considered ‘a moral, professional, imperative.’ Unfortunately, well-established, valid readily available operational measures performance misdiagnosis-related harms lacking, hampering progress. Existing...
Background and purpose A subset of ischaemic stroke patients with atrial fibrillation (AF) have despite anticoagulation. We sought to determine the association between prestroke anticoagulant therapy recurrent events symptomatic intracranial haemorrhage (sICH). Methods included consecutive acute AF from Initiation Anticoagulation after Cardioembolic (IAC) study eight comprehensive centres in USA. compared delayed sICH risk using adjusted Cox regression analyses who were prescribed...
Prior research suggests that women with endometriosis are at greater risk of coronary heart disease. Therefore, our objective was to prospectively investigate the association between laparoscopically confirmed and incident stroke during 28 years follow-up. Participants in NHSII cohort study (Nurses' Health Study II) were followed from 1989 when they ages 25 42 until 2017 for development (ischemic hemorrhagic). Cox proportional hazard models used calculate ratios 95% CI, adjustment potential...
An unintended consequence of rapid thrombolysis may be more frequent treatment stroke mimics, nonvascular conditions that simulate stroke. We explored the relationship between door-to-needle (DTN) times and mimics at a single academic center by analyzing consecutive quartiles patients who were treated with IV tissue plasminogen activator for suspected from January 1, 2010 to February 28, 2014. increase in proportion mimic (6.7% each 1st 2nd, 12.9% 3rd, 30% last case quartile; p = 0.03)...
Background and Purpose— The first of the 2 NINDS (National Institute Neurological Disorders Stroke) Study trials did not show a significant increase in early neurological improvement, defined as National Institutes Health Stroke Scale (NIHSS) improvement by ≥4, with alteplase treatment. We hypothesized that percentage change NIHSS (percent NIHSS) at 24 hours is superior to other definitions predicting 3-month functional outcomes using this definition there would be treatment benefit over...
Rates of cerebral venous thrombosis (CVT) misdiagnosis in the emergency department and outcomes associated with have been underexplored.Using administrative data, we identified adults CVT at New York, California, Florida hospitals from 2005 to 2013. Our primary outcome was probable CVT, defined as a treat-and-release visit for headache or seizure within 14 days before CVT. In addition, logistic regression used compare rates clinical patients without misdiagnosis. We performed confirmatory...
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Background: Administrative data can be useful for stroke research but have historically lacked on severity. Hospitals increasingly report the National Institutes of Health Stroke Scale (NIHSS) score using an International Classification Diseases , Tenth Revision ( ICD-10 ) diagnosis code, this code’s validity remains unclear. Methods: We examined concordance NIHSS scores versus recorded in CAESAR (Cornell Acute Academic Registry). included all patients with acute ischemic from October 1,...
Introduction: Facilitating evidence-based uptake of new medication regimens for disease prevention is a well-recognized public health challenge. Using data from GWTG-Stroke, researchers previously reported that, after minor ischemic stroke (NIHSS 0-3), the use aspirin-clopidogrel highly variable despite guideline recommendations. We sought to explore potential changes in dual antiplatelet therapy (DAPT) patients with moderate 4-5) publication THALES (The Acute Stroke or Transient Ischemic...
Background: Cervical artery dissection (CeAD) accounts for a quarter of strokes in young adults. Clinical presentation is often non-specific, leading to significant proportion cases being misdiagnosed. This study aims identify factors contributing potential misdiagnosis and assess the impact on patient outcomes. Methods: secondary analysis Antithrombotics Stroke Prevention Artery Dissection (STOP-CAD), multicenter cross-sectional international retrospective adult patients presenting an acute...
Introduction: Stroke is a leading cause of maternal morbidity and mortality, the incidence stroke triple that age-matched, non-pregnant counterparts. Mechanisms pregnancy-related differ compared to those population, but few data exist regarding presenting signs symptoms stroke, which often missed at initial presentation. We characterized by subtype in large retrospective multicenter case series. Methods: reviewed cases pregnant postpartum patients 5 centers. Eligible were between ages 18-50...
Background: Small studies have found that patients presenting with posterior circulation ischemic strokes are more likely than anterior to suffer a missed or delayed diagnosis in the ED. We evaluated whether probable ED stroke misdiagnosis was common among subsequently hospitalized versus acute using large, multistate cohort. Methods: conducted retrospective cohort study administrative claims data from Healthcare Cost and Utilization Project on all hospital admissions visits across 11 states...
Background: A recent prospective study reported that myocardial infarction (MI) was present in nearly half of ischemic stroke patients with substantially elevated troponin, 1 5 having a type MI. The proportion whom cardiac key component diagnosing MI, is checked at Emergency Department (ED) presentation unknown. We therefore used population-level data to report the frequency troponin assessments among U.S. presenting emergently symptoms and identify factors associated testing. Methods: Using...
Introduction: Cerebral amyloid angiopathy (CAA) can present with transient focal neurological episodes and is itself associated a heightened risk of intracerebral hemorrhage (ICH). Therefore, in patients suspected ischemic attack (TIA), CAA impact diagnostic evaluation antithrombotic management. However, among presenting possible TIA, there are few data on the prevalence its future cerebrovascular events mortality. Methods: We retrospectively analyzed consecutive to Bern University Hospital,...
Introduction: Cerebral amyloid angiopathy (CAA) is a significant cause of cerebrovascular disease and cognitive decline in elderly patients. There are limited population-based data regarding the prevalence CAA associated risks mortality incident events. Methods: We performed retrospective cohort study using inpatient outpatient claims from 2008 to 2018 nationally representative 5% sample Medicare beneficiaries. ischemic hemorrhagic stroke were identified previously validated ICD-10 codes....
Background: To study the risk of incident dementia after a non-traumatic intracranial hemorrhage in diverse US population, and evaluate if this is different for subtypes hemorrhage. Methods: We performed retrospective cohort using both inpatient outpatient claims data on Medicare beneficiaries between January 1, 2008 December 31, 2018. The exposure was new diagnosis hemorrhage, defined as composite intracerebral (ICH), subarachnoid (SAH), subdural (SDH). outcome first-ever dementia. outcomes...
Background: Cancer is associated with an increased risk for atrial fibrillation. However, there are no existing data supporting independent relationship between cancer and cardiopathy, another pathology acute ischemic stroke (AIS) risk. We investigated the cardiopathy among patients AIS. Methods: conducted a retrospective cross-sectional study consecutive hospitalized AIS at quaternary care center in New York City from 2011 through 2016. The exposure was active cancer. outcome defined as...
Introduction: Stroke is a leading cause of maternal morbidity and mortality, hemorrhagic strokes account for up to half these cases. Prior studies in non-maternal populations demonstrated that 9% are missed at initial ED presentation. We hypothesized pregnant or postpartum patients with acute stroke would have higher odds delayed diagnosis the time their presentation, compared those thrombotic (arterial ischemic [AIS] cerebral venous thrombosis [CVT]). Methods: retrospectively identified...
There are limited population-based data regarding the prevalence of cerebral amyloid angiopathy (CAA) and associated risks mortality incident cerebrovascular events. We performed a retrospective cohort study using inpatient outpatient claims from 2008 to 2022 5% national sample Medicare beneficiaries. CAA ischemic hemorrhagic stroke were identified validated International Classification Diseases 10th Revision (ICD-10) codes. ascertained October 1, 2015 through 2022, used September 30,...
Background and Purpose— Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity pelvic veins might be an embolic source cryptogenic (CS) Methods— Consecutive adult or transient attack ovale who underwent magnetic resonance venography part inpatient diagnostic evaluation were included this single-center retrospective observational study to determine (LE) venous...