A5102906666- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Peripheral Artery Disease Management
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Nerve Injury and Rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Nerve Disorders
- Moyamoya disease diagnosis and treatment
- Neurofibromatosis and Schwannoma Cases
- Cardiac, Anesthesia and Surgical Outcomes
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Brain Metastases and Treatment
- Artificial Intelligence in Healthcare and Education
Thomas Jefferson University Hospital
2024-2025
Neurological Surgery
2016-2025
Thomas Jefferson University
2016-2025
University of Michigan
2019-2024
A. Alfred Taubman Health Care Center
2021
Oxford University Press (United Kingdom)
2020
Drexel University
2012-2017
Jefferson Hospital for Neuroscience
2016-2017
Allegheny General Hospital
2016-2017
Allegheny Health Network
2017
Introduction: The impact of multiple feeding arteries on clinical outcomes cerebral arteriovenous malformations (AVMs) is not well understood. This study aims to compare between AVMs with versus single arteries. Patients and Methods: Data from the Multicenter International Study for Treatment Brain (MISTA) consortium were analyzed. Propensity score matching (PSM) was used balance cohorts. Subgroup analysis conducted ruptured unruptured different treatment options, multivariable logistic...
Histone acetylation of chromatin promotes dynamic transcriptional responses in neurons that influence neuroplasticity critical for cognitive ability. It has been demonstrated Tip60 histone acetyltransferase (HAT) activity is involved the regulation genes enriched neuronal function as well control synaptic plasticity. Accordingly, implicated neurodegenerative disorder Alzheimer's disease (AD) via regulatory complex formation with AD linked amyloid precursor protein (APP) intracellular domain...
Abstract BACKGROUND: Dissection of the carotid and vertebral arteries is an important cause stroke in young patients. OBJECTIVE: The objective this study to compare antithrombotic treatments patients with dissections. METHODS: Three hundred seventy artery dissections were included. Univariate multivariate analyses conducted analyze association between treatment new or recurrent events clinical outcome. RESULTS: Mean follow-up was 24.3 months. In spontaneous dissection, 55% received...
Sp1 is a ubiquitously expressed transcription factor that phosphorylated by ataxia telangiectasia mutated kinase (ATM) in response to ionizing radiation and H(2)O(2). Here, we show indirect immunofluorescence on serine 101 (pSp1) localizes radiation-induced foci with histone variant γH2Ax members of the MRN (Mre11, Rad50, Nbs1) complex. More precise analysis occupancy DNA double-strand breaks (DSBs) chromatin immunoprecipitation (ChIP) shows Sp1, like Nbs1, resides within 200 bp DSBs. Using...
Both monocyte-derived macrophages (MDMs) and brain resident microglia participate in hematoma resolution after intracerebral hemorrhage (ICH). Here, we utilized a transgenic mouse line with enhanced green fluorescent protein (EGFP) labeled (Tmem119-EGFP mice) combined F4/80 immunohistochemistry (a pan-macrophage marker) to visualize changes MDMs ICH. A murine model of ICH was used which autologous blood stereotactically injected into the right basal ganglia. The co-injected CD47 blocking...
Importance Stroke-to-recanalization time is a strong predictor of outcomes in anterior circulation large-vessel occlusion (LVO). The authors aimed to evaluate functional early (<6 h) vs. late (6–24 windows for thrombectomy-treated basilar artery occlusions. Methods Patients were derived from the Posterior Circulation Ischemic Stroke Evaluation: Analyzing Radiographic and Intra-procedural Predictors Mechanical Thrombectomy (PC-SEARCH) Registry retrospectively analyzed thrombectomy...
Recent randomized controlled trials demonstrated superiority of mechanical thrombectomy compared to medical therapy in acute basilar artery occlusions, however, little data is available guide clinicians functional prognosis and risk stratification.
Background: Stroke remains a leading cause of mortality and morbidity, with treatment outcomes differing across ethnic groups. Tele-stroke networks have expanded access to stroke care, particularly in underserved areas, but the impact ethnicity on these is still being explored. This study aims compare among White/Caucasian, African-American, Other groups within tele-stroke network. Methods: We conducted retrospective analysis 4,256 patients treated network spanning 38 hospitals. Patients...
Introduction: Mechanical thrombectomy (MT) is the standard of care in patients presenting with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Early recanalization critical restoring blood flow brain tissue. Previous literature has reported disparities access MT capable centers AIS. identification eligibility could help stratify centers. Our study created an artificial intelligence (AI)-driven chatbot determine for MT. Methods: Guidelines established by American Heart...
Background: Stroke is a leading cause of death and disability globally, with timely intervention being critical to improving patient outcomes. Tele-stroke networks have been developed bridge the gap in stroke expertise, particularly rural areas where multidisciplinary care scarce. This study aims compare outcomes between male female patients within large tele-stroke network. Methods: We conducted retrospective analysis 7,947 who were evaluated for acute ischemic symptoms via network...
Introduction: Patients undergoing carotid artery stenting (CAS) are placed on dual antiplatelet therapy (DAPT) to minimize the risk of thromboembolic complications. DAPT carries a events in hypo-responders or hemorrhagic hyper-responders clopidogrel. Despite platelet function testing (PFT) being routinely performed, recent literature has reported varying efficacy its utility preventing complications after neurointerventional procedures. Our study evaluates PFT extracranial CAS. Methods: This...
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy is used to minimize thromboembolic complications after flow diversion (FD). Oral anticoagulation (AC) has been associated with increased risk of hemorrhagic complications. Our multicenter study and systematic review literature describes the safety efficacy FD in patients on concurrent AC. METHODS: This was a retrospective AC before for an intracranial aneurysm at 3 participating institutions between January 2018 2024. Outcomes interest...
The aim of this study was to examine the role intraoperative neuromonitoring (IONM) during resection benign peripheral nerve sheath tumors in achieving gross-total (GTR) and reducing postoperative neurological complications.
Abstract Background Thrombin has been implicated in playing a role hydrocephalus development following intraventricular hemorrhage (IVH). However, the mechanisms underlying sex differences to detrimental effects of thrombin post-IVH remain elusive. Method Three-month old male and female Sprague-Dawley rats underwent unilateral intracerebroventricular (ICV) injections 3U or 5U thrombin, saline, examine thrombin-induced white matter injury. Mortality, lateral ventricle volume injury were...
Abstract Aims White matter (WM) injury is a critical factor associated with worse outcomes following subarachnoid hemorrhage (SAH). However, the detailed pathological changes are not completely understood. This study investigates temporal in corpus callosum (CC), including WM edema and oligodendrocyte death after SAH, role of lipocalin‐2 (LCN2) those changes. Methods Subarachnoid was induced adult wild‐type or LCN2 knockout mice via endovascular perforation. Magnetic resonance imaging...