Deepak Kumbhare
A5037552500- Neurological disorders and treatments
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Genetic Neurodegenerative Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Advanced MRI Techniques and Applications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Functional Brain Connectivity Studies
- Conducting polymers and applications
- Neural dynamics and brain function
- Head and Neck Surgical Oncology
- Neural Networks and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Meningioma and schwannoma management
- Electrochemical Analysis and Applications
- Neurological and metabolic disorders
- Neurofibromatosis and Schwannoma Cases
Louisiana State University in Shreveport
2023-2025
The University of Texas Health Science Center at Houston
2025
Louisiana State University Health Sciences Center Shreveport
2022-2025
Louisiana State University
2025
Virginia Commonwealth University
2014-2024
University Health System
2018-2024
Orthopaedic Research of Virginia
2024
Hunter Holmes McGuire VA Medical Center
2014-2023
Harvard University
2023
University of Richmond
2019
Background Brain arteriovenous malformations (AVMs) are abnormal connections between feeding arteries and draining veins, associated with significant risks of haemorrhage, seizures other neurological deficits. Preoperative embolization is commonly used as an adjunct to microsurgical resection, the aim reducing intraoperative complications improving outcomes. However, efficacy safety this approach remain controversial. Methods This study a subanalysis Multicenter International Study for...
Background: Arteriovenous malformations (AVMs) are complex vascular anomalies with a high risk of hemorrhage and neurological deficits, especially when located in eloquent brain regions. The eloquence an AVM location is critical factor the treatment planning, influencing both complications long-term functional outcomes. This study aims to compare outcomes between non-eloquent AVMs. Methods: multicenter, retrospective utilized data from Multicenter International Study for Treatment Brain AVMs...
Introduction: The impact of multiple feeding arteries on clinical outcomes cerebral arteriovenous malformations (AVMs) is not well understood. This study aims to compare between AVMs with versus single arteries. Patients and Methods: Data from the Multicenter International Study for Treatment Brain (MISTA) consortium were analyzed. Propensity score matching (PSM) was used balance cohorts. Subgroup analysis conducted ruptured unruptured different treatment options, multivariable logistic...
Intraoperative navigation is critical during spine surgery to ensure accurate instrumentation placement. From the early era of fluoroscopy current advancement in robotics, spinal has continued evolve. By understanding variations system protocols and their respective usage operating room, surgeon can use maximize potential various image guidance options more effectively. At same time, maintaining accuracy throughout procedure utmost importance, which be confirmed intraoperatively by using an...
Abstract Cerebral arteriovenous malformations (AVMs) are congenital vascular anomalies that can lead to severe complications, including hemorrhage and neurological deficits. This study compares the outcomes of microsurgical resection stereotactic radiosurgery (SRS) for SM grade I II AVMs. Out a large multicenter registry, we identified 180 matched patients with AVMs treated either or SRS between 2010 2023. The primary were AVM obliteration rates complications; secondary included status...
Deep brain stimulation (DBS) of nucleus basalis Meynert (NBM) is currently being evaluated as a potential therapy to improve memory and overall cognitive function in dementia. Although, the animal literature has demonstrated robust improvement functions, phase 1 trial results humans have not been clear-cut. We hypothesize that this may reflect differences electrode location within NBM, type timing stimulation, lack biomarker for determining stimulation's effectiveness real time. In article,...
Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales regions. Microelectrode arrays (MEAs) are widely used record neurophysiological activity various depths regions, providing single-unit resolution for extended periods. Recent advancements in flexible MEAs, built on micrometer-thick polymer substrates, have improved integration with tissue by mimicking the brain's soft nature, reducing mechanical trauma...
INTRODUCTION: Deterioration of the basal nucleus Meynert (NBM) is a key feature associated with dementia. The cholinergic projections NBM serve as primary source Acetylcholine (ACh) for entire neocortex. Research has demonstrated that enhances cortical activity by influencing ACh release, which in turn affects neuro-excitability, spectral topography, and intra-cortical signaling Moreover, neurons have been observed to modulate their firing patterns during various cognitive processes....
Background/Objectives: Surgical site infections (SSIs) in spine surgery pose significant risks, including neurological deficits, prolonged hospital stays, and increased healthcare costs. SSIs are classified by their location include superficial, deep, organ/space (OS) infections. In surgery, OS osteomyelitis, discitis, spinal epidural abscess. These difficult to treat with conservative measures, impart morbidity, incur increasing Despite advancements surgical technique infection control, the...
Intraoperative neurophysiological monitoring (IONM) provides data on the state of neurological functionality. However, current technology impedes reliable and timely extraction communication relevant information. Advanced signal processing machine learning (ML) technologies can develop a robust surveillance system that reliably monitor patient's nervous promptly alert surgeons any imminent risk. Various ML tools be utilized to real-time, objective, multi-modal IONM based-alert for spine...
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique used to regulate the synaptic activity of neurons in brain, improving functionality connecting regions and bringing effective treatment different neurological psychiatric disorders. The TMS induced E-field needs be focal enough avoid unwanted side effects caused by adjacent target. Attempts at small animals like rodents are highly constrained, since most these studies use commercial equipment intended for...
Abstract Although manifesting contrasting phenotypes, Parkinson's disease and dystonia, the two most common movement disorders, can originate from similar pathophysiology. Previously, we demonstrated that lesioning (silencing) of a discrete dorsal region in globus pallidus (rodent equivalent to externa) rats produced parkinsonism, while nearby ventral hotspot‐induced dystonia. Presently, injected fluorescent‐tagged multi‐synaptic tracers into these pallidal hotspots ( n = 36 Long Evans rats)...