A5064040831- Corneal surgery and disorders
- Glaucoma and retinal disorders
- RNA modifications and cancer
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ocular Oncology and Treatments
- Ophthalmology and Visual Impairment Studies
- RNA Interference and Gene Delivery
- COVID-19 diagnosis using AI
- Venomous Animal Envenomation and Studies
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Traumatic Ocular and Foreign Body Injuries
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Ocular Disorders and Treatments
- Cholesterol and Lipid Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Intraocular Surgery and Lenses
The University of Texas Southwestern Medical Center
2025
Southwestern Medical Center
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Hebei Medical University
2021-2024
Second Hospital of Hebei Medical University
2021-2024
Academy of Medical Sciences
2022
Tianjin Medical University
2022
Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines...
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells...
Understanding how subcellular structures and events shape tissue-wide phenomena remains a central challenge in biology. We present Multiscale Cleared Tissue Axially Swept Light-Sheet Microscopy (MCT-ASLM), platform combining cm-scale imaging with targeted high-resolution interrogation of intact tissues human-guided or autonomous modes. Capable capturing fields view up to 21 mm at micron-scale resolution, MCT-ASLM can seamlessly transition submicron (~300 nm) isotropic resolution for imaging....
Correspondence freeReply: Vector Planning and Ocular Residual Astigmatism (ORA) Source Reference Other KLEx Studiesis a reply to letterVector Studies Qing Su, MD, , MD Shuang Liang, Huazheng Cao, Mengyuan Shan, Yan Wang, PhD, PhD Journal of Refractive Surgery, 2025;41(3):e288–e289Cite this articlePublished Online:March 01, 2025https://doi.org/10.3928/1081597X-20250224-01 PDF ToolsAdd favoritesDownload CitationsTrack Citations ShareShare onFacebookxLinkedInRedditEmailBluesky...
To evaluate the effects of ocular residual astigmatism (ORA) on refractive outcomes for patients with after keratorefractive lenticule extraction (KLEx) and to identify ratio ORA/manifest cylinder at corneal plane (MRC) resulting in a greater index success (IOS).
While some lung adenocarcinoma (LUAD) patients benefit long-term from treatment with immune checkpoint inhibitors, the sad reality is that a considerable proportion of do not. The classification LUAD tumor microenvironment (TME) can be used to conceptually comprehend primary resistance mechanisms. In addition, most recent research demonstrates release damage-associated molecular pattern (DAMP) in TME by immunogenic cell death (ICD) may contribute adaptive response. Currently, however, there...
The efficient cytosolic delivery of the CRISPR-Cas9 machinery remains a challenge for genome editing. Herein, we performed ligand screening and identified guanidinobenzol-rich polymer to overcome cascade barriers ribonucleoproteins (RNPs) RNPs were stably loaded into polymeric nanoparticles (PGBA NPs) by their inherent affinity. facilitated rapid endosomal escape via dynamic multiple-step process. Importantly, incorporation fluorescence in helps identify correlation between cellular uptake...
This study aimed to develop effective artificial intelligence (AI) diagnostic models based on CT images of pulmonary nodules only, descriptional and quantitative clinical or image features, a combination both differentiate benign malignant ground-glass (GGNs) assist in the determination surgical intervention.Our included total 867 (benign nodules: 112; 755) with postoperative pathological diagnoses from two centers. For discriminate between GGNs, we adopted three different approaches: a) an...
To investigate the clinical characteristics and factors affecting visual outcome in patients with intraocular foreign bodies (IOFBs) determine risk for development of endophthalmitis. Study Design. A retrospective case-series study design was adopted. In total, 242 (242 eyes) who were hospitalized underwent surgical treatment IOFB at Second Hospital Hebei Medical University between January 1, 2008, December 31, 2019, included. The demographic data, cause injury, IOFBs, postinjury ocular...
MicroRNA-92a (miR-92a) may serve as a novel promising biomarker in multiple cancers, including colorectal cancer (CRC); however, the diagnostic accuracy and underlying molecular mechanism of miR-92a CRC is poorly understood. We first carried out meta-analysis found that serum/plasma yield better efficacy when compared to stool samples tissues, this finding was validated by our independent study through sample. Multiple bioinformatics assay indicated expression positively correlated with...
To investigate macular microperimetry in patients with early primary open angle glaucoma (POAG) using a new custom-made pattern, and analyze the characteristics of sensitivity.
This retrospective study aimed to identify the key factors influencing postoperative refraction after small-incision lenticule extraction (SMILE) using information gain. comprised 2,350 eyes of 1,200 patients who underwent SMILE a Visumax 500-kHz femtosecond laser (Carl Zeiss Meditec AG) in three ophthalmic centers: Tianjin Eye Hospital (center A), Jinan Mingshui B), and Qingdao C). Anterior segment features, including corneal curvature central thickness (CCT), were obtained from Pentacam HR...
Abstract Background MicroRNA-92a (miR-92a) may serve as a novel promising biomarker in multiple cancers including colorectal cancer (CRC). However, the diagnostic accuracy and underlying molecular mechanism of miR-92a CRC is poorly understood. Method Diagnostic studies were retrieved from PubMed, Embase, Cochrane Library, Web Science, up until May 2022. Besides, an independent validation participants group (n = 144) was recruited for stool test to prove diagnosis efficiency CRC. Then,...