Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines...

Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells...

Immunotherapies have shown high clinical success, however, the therapeutical efficacy is largely restrained by insufficient immune activation and an immunosuppressive microenvironment. Herein, we report tumor microenvironment (TME)-responsive manganese-enriched zinc peroxide nanoparticles (MONPs) for synergistic cancer immunotherapy inducing immunogenic death (ICD) of cells activating stimulator interferon gene (STING) pathway. MONPs especially disassociate upon exposure to acidic tissue in...

The highly immunosuppressive tumor microenvironment (TME) restricts the efficient activation of immune responses. To restore surveillance system for robust activation, vast efforts are devoted to normalizing TME. Here, a manganese-doped layered double hydroxide (Mn-LDH) is developed potent anti-tumor immunity by reversing Mn-LDH synthesized via one-step hydrothermal method. In addition inherent proton neutralization capacity LDH, introduction manganese oxide endows LDH with an additional...

Advanced gastric cancer (GC) has a poor prognosis and its treatment strategies are not very efficient. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) emerged as plausible GC marker, however the role molecular mechanism of hnRNPA1 in cell invasion migration remains unknown. In present study, gene expression across normal tumor tissue (GENT) database was used to evaluate mRNA various types cancer. Western blot analysis (WB) immunohistochemistry (IHC) were performed detect protein tissues...

This paper examines how AI at work impacts on-the-job learning, shedding light on workers’ reactions to the groundbreaking technology. Based theoretical analysis, six hypotheses are proposed regarding three aspects of AI’s influence learning. Empirical results demonstrate that significantly inhibits people’s learning and this conclusion holds true in a series robustness endogeneity checks. The impact mechanism is makes workers more pessimistic about future, leading burnout less motivation...

Understanding community assembly mechanisms along the geographical gradients is of great importance in ecological research. The Taihang Mountains are intersection north and south flora, with abundant species complex structures, which provide multiple services. However, phylogenetic structure composition woody plants still not very well understood. In this study, 35 forest dynamic plots were established natural distribution areas from 850 to 1850 m above sea level. We explored pattern...

Abstract Considerable evidence suggests that breast cancer therapeutic resistance and relapse can be driven by polyploid giant cells (PGCCs). The number of PGCCs increases with the stages disease stress. Given importance PGCCs, it remains challenging to eradicate them. To discover effective anti-PGCC compounds, there is an unmet need rapidly distinguish compounds kill non-PGCCs, or both. Here, we establish a single-cell morphological analysis pipeline high throughput great precision...

Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein‐coupled kinase 2) is an essential regulator for many G receptors and subsequent cell signaling cascades, but its role as a of associated cardiac hypertrophy hypertension remains be elucidated. Methods Results In this study, we found the expressions peripheral blood mononuclear cells were positively with pressure levels hypertensive patients...

As part of the central nervous system (CNS), retinal ganglion cells (RGCs) and their axons are only neurons in retina that transmit visual signals from eye to brain via optic nerve (ON). Unfortunately, they do not regenerate upon injury mammals. In ON trauma, microglia (RMG) become activated, inducing inflammatory responses resulting axon degeneration RGC loss. Since aldose reductase (AR) is an response mediator highly expressed RMG, we investigated if pharmacological inhibition AR can...

Macropanax rosthornii (Harms) C.Y.Wu ex G.Hoo 1900 is a small tree or evergreen shrub of the family Araliaceae, mainly distributed in southern China and Vietnam with distribution area. M. kind high-quality wild ornamental plant resource also known for its effective medicinal treatment fracture, rheumatoid arthritis, traumatic injury, infant malnutrition, etc. In this study, first complete chloroplast genome was reported phylogenetic analysis conducted other 10 species from Araliaceae. The...

Hippophae rhamnoides subsp. turkestanica is mainly distributed in the mountains, valleys, and desert edges of Central Asia. It plays a vital role maintaining ecological stability arid semiarid areas. In this study, MaxEnt model was used to simulate habitat suitability H. turkestanica, key environmental factors affecting its distribution were identified. Additionally, we explored sensitivity climate change, provided essential information for conservation management important subspecies...

This paper describes the synthesis of a novel chlorinated sorbent through one-step pyrolysis waste polyvinyl chloride (PVC)/coal blends and its application for elemental mercury removal. The effects temperature (600, 700, 800 °C) mixing ratio (9:1, 3:1) on Hg0 adsorption efficiency was tested in laboratory-scale fixed bed reactor. For sorbents T8C9P1 T83P1, complete removal maintained 30 min at 140 °C. Ion chromatography (IC) analysis, Brunauer–Emmett–Teller (BET) surface area, X-ray...

Abstract In this study, total flavonoids and triterpenoid acid were extracted with ethyl acetate from Hedyotis diffusa Willd, hepatoprotective activities of them five compounds against H 2 O induced hepatocyte damage on HL‐02 cells determined. particular, amentoflavone had influence the leakage ALT, AST, LDH, SOD content MDA. They effectively reduced loss MMP, release Cyt C, then inhibited activation caspase‐3/caspase‐9 cascade in hepatotoxic cells. The contents ROS significantly to inhibit...

An interspecific association represents an inter-relatedness of different species in spatial distribution and combined with the altitude factor, is key for revealing formation evolution ecological community. Therefore, we analyzed changes community stability at altitudes southern Taihang Mountains using variance ratio (VR), χ2 test, coefficient (AC), percentage co-occurrence (PC) Godron method. In total, 27 sample plots measuring 20 × m were set up divided into lower (700~1100 m), medium...

Modified water models with scaled charges are used to investigate solvent polarity effects on DNA structure. Several intensive molecular dynamics simulations of the EcoRI dodecamer d(CGCGAATTCGCG) in different model solvents performed. When molecule decreases, from overpolarized less polarized, experiences conformational transitions $\mathrm{\text{constrained}}\ensuremath{\rightarrow}B\text{ }\text{...