Abstract The synthesis of dynamic chiral lanthanide complex emitters has always been difficult. Herein, we report three pairs Eu III ( R/S -Eu-R-1 , R = Et/Me; -Eu-Et-2 ) with aggregation-induced emission. In the molecular state, these complexes have almost no obvious emission, while in aggregate they greatly enhance emission through restriction intramolecular rotation and vibration. asymmetry factor circularly polarized luminescence brightness are as high 0.64 5 D 0 → 7 F 1 2429 M −1 cm...

Enhancing the "antenna effect" of ligands and promoting energy transfer to a lanthanide metal center is one most effective ways construct complex-based emitters with bright emissions. Herein, highly stable nanoclusters (Ln9Zn8; Ln = Dy, Tb, Eu, or Gd) were constructed using Zn(II) metalloligand protection strategy, "dual antenna was selectively turned on enhance luminescence Eu9Zn8. The enabled dual effect for Eu9Zn8, resulting in its solid state being significantly stronger than that...

The immediate control of a hemorrhage is crucial for reducing fatalities in critical situations such as battlefields, traffic accidents, natural disasters, etc. Most existing commercial hemostatic powders have weak adhesion capability and poor biodegradability, restricting their clinical use. In this paper, new poly(ethylene glycol)-di(cyanoacrylate) (CA-PEG-CA)-based powder with tissue-contact-triggered strong controlled fast degradation proposed. monomers quickly underwent crosslinking...

The development of novel photocatalytic systems for energy-saving and efficient water purification sterilization is extremely challenging but crucial the prevention chronic diseases caused by pollution bacteria. self-aggregation photosensitizers (PSs) driven tight π–π stacking leads to a sharp decline in ability generate reactive oxygen species (ROS) has become main bottleneck application PSs sterilization. Herein, series porous anthracene-based metal–organic frameworks (MOFs)...

Abstract Spatiotemporally increasing intracellular reactive oxygen species (ROS) level represents a promising and effective antitumor approach, but is significantly hindered by insufficient ROS sources within the tumor. Herein, Cu‐porphyrin based nanoscale metal‐organic framework (nMOF) Cu II MOF reported, which inherently integrates chemodynamic therapy (CDT), photodynamic (PDT), photocatalytic capabilities to generate storm for cancer immunotherapy. Unlike conventional porphyrin‐based...

Usually, complexes with different connections and shapes are constructed by regulating the substituents. However, it is extremely challenging to construct two lanthanide dimensions only fine-tuning substituents of ligands, especially (−CH3 −CH2CH3) almost similar physical chemical properties. Herein, multidentate chelating connection modes were successfully using a multicomponent "one-pot method" under guidance coordination method (MCC). They 11-nuclear molecular cluster (Dy11) metal–organic...

Abstract In this study, a simple and rapid strategy is developed for the gram‐scale synthesis of zinc(II) halide complexes with ultralong afterglow under mild conditions. Crystalline, high‐purity are synthesized using N ‐methylbenzimidazole ( Bz ) common zinc salts (ZnX 2 , X = Cl, Br, I) as cheap industrial raw materials by stirring at room temperature atmospheric pressure. By exploiting steric effect terminal‐coordinated halogen ions to regulate arrangements ligands in structure complexes,...

Abstract In this study, total flavonoids and triterpenoid acid were extracted with ethyl acetate from Hedyotis diffusa Willd, hepatoprotective activities of them five compounds against H 2 O induced hepatocyte damage on HL‐02 cells determined. particular, amentoflavone had influence the leakage ALT, AST, LDH, SOD content MDA. They effectively reduced loss MMP, release Cyt C, then inhibited activation caspase‐3/caspase‐9 cascade in hepatotoxic cells. The contents ROS significantly to inhibit...

Hedyotis Diffusa Willd, used in Traditional Chinese Medicine, is a treatment for various diseases including cancer, owing to its mild effectiveness and low toxicity. The aim of this study was identify the main anticancer components explore mechanisms underlying their activity. Willd extracted fractionated using ethyl acetate obtain H-Ethyl fraction, which showed higher activity than other fractions obtained against HepG2 cells with sulforhodamine B assays. active component fraction...

We are the first to achieve directional construction of chiral lanthanide clusters by regulating hydroxyl coordination sites at different positions on ligands manipulating annular growth mechanism.

Lanthanoid metal ions have large ionic radii, complex coordination modes, and easy distortion of spheres, but the design synthesis high-nucleation lanthanoid clusters with high stability in solution (especially aqueous solution) are challenging. Herein, a diacylhydrazone ligand (H2L1) multidentate chelating sites was used to react Dy(OAc)3·4H2O under solvothermal conditions obtain an example 34-nucleus crown-shaped dysprosium cluster...

We have synthesized a drone-shaped lanthanide cluster 1, and its possible self-assembly mechanism was speculated. observed the transition from crystalline to amorphous high-nuclear clusters for first time.

The complex hydrolysis process and strong uncertainty of self-assembly rules have led to the precise synthesis lanthanide clusters still being in "blind-box" stage simplifying developing reliable regulation strategies attracted widespread attention. Herein, different anions are used induce construction a series dysprosium with shapes connections. When selected anion is NO

The serialized expansion of high-nuclear clusters usually includes the controlled variable method and changes only a single variable. However, changing both variables will greatly increase complexity reaction simultaneously. Therefore, use two-component regulation is rare. Herein, we used diacylhydrazone ligand (H4L1) with multidentate chelating coordination sites for Gd(NO3)3·6H2O under solvothermal conditions to obtain an example 16-nucleus disc-shaped cluster 1 brucite structure. overall...

Abstract The mechanisms by which the strong antitumor diorganotin(IV) compound di‐ n ‐butyl‐di‐(4‐chlorobenzohydroxamato)tin(IV) (DBDCT) induces apoptosis of SGC‐7901 cells were first investigated. Inhibition proliferation four cancer cell lines compared with normal human hepatic L‐O2 cells, apoptosis, and expression related mRNA protein detected using methyl thiazolyl tetrazolium (MTT), flow cytometry, reverse transcription polymerase chain reaction (RT‐PCR), Western blot, DNA ladder...

Di-n-butyl-(2,6-difluorobenzohydroxamato)Tin(IV) (DBDFT), a potential antitumor agent against malignancies, exhibited high activities both in vitro and vivo. Flow cytometric analysis showed that treatment with DBDFT Human Gastric Carcinoma (SGC-7901) cells induced concentration time-dependent cell accumulation the G2/M phase of cycle parallel depletion percentage G0/G1, apoptosis was observed by characteristic morphological changes AnnexinV/PI dual-immunofluorescence staining. Fluorescence...

Carvacrol, as the major components of aromatic plants used for treating human skin diseases including origanum, Satureja, thymus, and coridothymus species, presented a kind antiviral activity. To explore mechanisms carvacrol against herpes simplex virus (HSV) in vitro.The BSC-1 cells model HSV infection was established, from two aspects viral replication level cell death pathway, effects on infected were also evaluated by plaque assay under three modes prevention, treatment, direct...