A5070100628- Childhood Cancer Survivors' Quality of Life
- Optimal Experimental Design Methods
- Statistical Methods in Clinical Trials
- Epigenetics and DNA Methylation
- Obstructive Sleep Apnea Research
- Stroke Rehabilitation and Recovery
- Protein purification and stability
- Neuroscience of respiration and sleep
- Advanced Drug Delivery Systems
- Cardiovascular Health and Risk Factors
- Family Support in Illness
- Advanced Causal Inference Techniques
- Palliative Care and End-of-Life Issues
- Glioma Diagnosis and Treatment
- Image Processing Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Fluorescence Microscopy Techniques
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Acute Lymphoblastic Leukemia research
- Regional Development and Environment
- Glycosylation and Glycoproteins Research
- Advanced Multi-Objective Optimization Algorithms
- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
St. Jude Children's Research Hospital
2020-2024
University of Utah
2021
University of Michigan
2020-2021
Taipei Municipal Jen-Ai Hospital
2020
Michigan United
2020
Genentech
2001
Sunesis (United States)
1996-1997
Duquesne University
1996
We evaluated whether combining a humanized antidisialoganglioside monoclonal antibody (hu14.18K322A) throughout therapy improves early response and outcomes in children with newly diagnosed high-risk neuroblastoma.
<h3>Objective</h3> To examine associations between neighborhood socioeconomic status (nSES) and 90-day poststroke outcomes. <h3>Methods</h3> The Brain Attack Surveillance in Corpus Christi Project is a population-based surveillance study Nueces County, Texas. Patients with strokes were identified 2010 2016 via active passive enrolled the study. nSES index standardized composite of Census tract–level income, wealth, education, employment (median −4.56, interquartile range −7.48 to −0.46)....
AbstractIncorporation of a protein drug in microspheres made hydrophobic polymer is commonly achieved via double liquid-liquid emulsification (w/o/w) or by dispersing powdered solution followed (s/o/w). This study focused on the effect first operating step both processes size and protein-loading microspheres. Bovine serum albumin (BSA) was used as model poly(methyl methacrylate) (PMMA) polymer. The w/o emulsion characterized based degree fineness which controlled using rotor/stator...
It is well-established that cancer treatment substantially increases the risk of long-term adverse health outcomes among childhood survivors. However, there limited research on underlying mechanisms. To elucidate pathophysiology and a possible causal pathway from exposures to cardiometabolic conditions, we conducted epigenome-wide association studies (EWAS) identify DNA methylation (DNAm) sites associated with examined whether treatment-associated DNAm mediate associations between specific...
Social epigenomics is an emerging field in which social scientist collaborate with computational biologists, especially epigeneticists, to address the underlying pathway for biological embedding of life experiences. This study included long-term childhood cancer survivors enrolled St. Jude Lifetime Cohort. DNA methylation (DNAm) data were generated using Illumina EPIC BeadChip, and three determinants health (SDOH) factors assessed: self-reported educational attainment, personal income, area...
A microencapsulation process for preparing protein-loaded microspheres based on a solvent-extraction method was scaled up using continuously stirred tank reactors (CSTR) from 1 L to 100 in batch size. This study concerned with developing quantitative correlation between the size of and parameters. The parameters considered include operational variables physical properties associated both dispersion dispersed phases. Dimensional analysis used establish such protein-free poly(lactic...
Temporal focusing multiphoton excitation microscopy (TFMPEM) enables fast widefield biotissue imaging with optical sectioning. However, under illumination, the performance is severely degraded by scattering effects, which induce signal crosstalk and a low signal-to-noise ratio in detection process, particularly when deep layers. Accordingly, present study proposes cross-modality learning-based neural network method for performing image registration restoration. In proposed method,...
Abstract While a number of phase I dose‐finding designs in oncology exist, the commonly used ones are either algorithmic or empirical model‐based. We propose new framework for modeling dose–response relationship, by systematically incorporating pharmacokinetic (PK) data collected trial and hypothesized mechanisms drug effects, via dynamic PK/PD modeling, as well relationship between latent cumulative pharmacologic effect binary toxicity outcome. This naturally incorporates information on...
Informal (unpaid) caregiving usually provided by family is important poststroke. We studied whether the prevalence of informal after stroke differs between Mexican Americans (MAs) and non-Hispanic Whites (NHWs).Between October 2014 December 2018, participants in BASIC (Brain Attack Surveillance Corpus Christi) project Nueces County, Texas, were interviewed 90 days to determine which activities daily living they required help with caregiving. Ethnic differences MAs NHWs determined logistic...
A dual-resonant scanning multiphoton (DRSM) microscope incorporating a tunable acoustic gradient index of refraction lens and resonant mirror is developed for rapid volumetric bioimaging. It shown that the achieves imaging rate up to 31.25 volumes per second (vps) volume 200 × 100 µm 3 with 256 128 voxels. However, images have severe negative signal-to-noise ratio (SNR) as result large number missing voxels presence Lissajous patterning residuals. Thus, modified three-dimensional...
PURPOSE To describe the trajectory of cognitive and adaptive functioning in pediatric patients with retinoblastoma from diagnosis through age 10. This is an extension a previous report that discussed findings 5. PATIENTS AND METHODS Ninety-eight participants completed psychological assessments as part their enrollment on institutional treatment protocol, 73 completing additional assessment at Trajectories were determined, data analyzed by strata, 13q- separately. RESULTS Longitudinal...
Abstract BACKGROUND Childhood brain tumor survivors treated with cranial irradiation are at significant risk for cognitive late effects that negatively impact quality of life. Memantine (an NMDA receptor antagonist), taken during radiotherapy metastases in adults, resulted reduced declines. This is the first investigation feasibility, acceptability, and preliminary efficacy memantine reducing children undergoing radiation therapy. METHODS In a randomized, double-blind, controlled trial...
Abstract For the cancer clinical trials with immunotherapy and molecularly targeted therapy, time‐to‐event endpoint is often a desired endpoint. In this paper, we present an event‐driven approach for Bayesian one‐stage two‐stage single‐arm phase II trial designs. Two versions of designs were proposed executable algorithms meanwhile, also develop theoretical relationships between frequentist These findings help investigators who want to design using have explicit understanding how properties...
Abstract Phase II exploratory multiarm studies that randomize among new treatments are found to be broadly useful and appear of value both scientifically logistically, especially in the areas unmet needs, for example, pediatric cancer. This design also has a faster recruitment rate because it provides patients with more treatment choices than traditional two‐arm randomized controlled trials do. In contrast direct formal comparisons multistage designs, umbrella or platform screened selection...
Abstract Background It is well-established that cancer treatment substantially increases risk of long-term adverse health outcomes among childhood survivors. However, there limited research on the underlying mechanisms. To elucidate pathophysiology and a possible causal pathway from exposures to cardiometabolic conditions, we conducted epigenome-wide association studies (EWAS) identify DNA methylation (DNAm) sites associated with examined whether treatment-associated DNAm mediate...
Introduction: While telestroke use is increasing, little known about its effect on the patient and family perceptions of quality stroke care. We hypothesized that may negatively impact communication with local physicians. Methods: Stroke patients aged 45 years older their surrogate medical decision makers were identified (April 2016-August 2018). Surrogates asked to rate main physician in charge patient’s care using a validated scale for (QOC, range 0-10). Using Tobit regression models, we...
Introduction: Sleep apnea (SA) is highly prevalent after stroke and associated with poor outcomes. Currently, stroke, a physiological test must be used to differentiate patients without SA. Within large, population-based study, we tested the usefulness of statistical models based on baseline characteristics predict Methods: Brain Attack Surveillance in Corpus Christi (BASIC) project, participants ischemic (2010-2018) underwent SA screening, shortly ApneaLink Plus portable sleep testing...
Introduction: Surrogate decision makers are commonly asked to make critical decisions after stroke, though there has been little formal study of stroke surrogates. We report initial results on surrogate in a community that does not have an academic medical center from the Outcomes Among In Stroke (OASIS) project. Methods: Patients with ischemic or intracerebral hemorrhage (ICH) Brain Attack Surveillance Corpus Christi (BASIC) project, Texas, USA, were screened for presence maker. Surrogates...