A5031102856- Chronic Disease Management Strategies
- Health disparities and outcomes
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Injury Epidemiology and Prevention
- Emergency and Acute Care Studies
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Global Health Care Issues
- Healthcare Policy and Management
- Medical Coding and Health Information
- Healthcare Systems and Reforms
- Healthcare cost, quality, practices
- Vaccine Coverage and Hesitancy
- Air Quality Monitoring and Forecasting
- Noise Effects and Management
- Primary Care and Health Outcomes
- Geriatric Care and Nursing Homes
- Healthcare Systems and Challenges
- Digital Mental Health Interventions
- Heparin-Induced Thrombocytopenia and Thrombosis
Swansea University
2015-2024
Health Data Research UK
2018-2024
Monash University
2024
University of Kentucky
2021
Center for Innovation
2021
Farr Institute
2015-2018
Northwestern University
2009
Duke University
2009
Albert Einstein College of Medicine
2009
United States Department of the Navy
2009
Introduction The emergence of the novel respiratory SARS-CoV-2 and subsequent COVID-19 pandemic have required rapid assimilation population-level data to understand control spread infection in general vulnerable populations. Rapid analyses are needed inform policy development target interventions at-risk groups prevent serious health outcomes. We aim provide an accessible research platform determine demographic, socioeconomic clinical risk factors for infection, morbidity mortality COVID-19,...
Abstract Background mortality in care homes has had a prominent focus during the COVID-19 outbreak. Care are particularly vulnerable to spread of infectious diseases, which may lead increased risk. Multiple and interconnected challenges face home sector prevention management outbreaks COVID-19, including adequate supply personal protective equipment, staff shortages insufficient or lack timely testing. Aim analyse older residents Wales lockdown compare this across population previous 4...
While population estimates suggest high vaccine effectiveness against SARS-CoV-2 infection, the protection for health care workers, who are at higher risk of exposure, is less understood.
Background Multimorbidity poses major challenges to healthcare systems worldwide. Definitions with cut-offs in excess of ≥2 long-term conditions (LTCs) might better capture populations complexity but are not standardised. Aim To examine variation prevalence using different definitions multimorbidity. Design and setting Cross-sectional study 1 168 620 people England. Method Comparison multimorbidity (MM) four definitions: MM2+ (≥2 LTCs), MM3+ (≥3 from 3+ LTCs ≥3 International Classification...
Background Multimorbidity prevalence rates vary considerably depending on the conditions considered in morbidity count, but there is no standardised approach to number or selection of include. Methods and findings We conducted a cross-sectional study using English primary care data for 1,168,260 participants who were all people alive permanently registered with 149 included general practices. Outcome measures estimates multimorbidity (defined as ≥2 conditions) when varying 80 conditions....
The CVD-COVID-UK consortium was formed to understand the relationship between COVID-19 and cardiovascular diseases through analyses of harmonised electronic health records (EHRs) across four UK nations. Beyond COVID-19, data harmonisation common approaches enable analysis within independent Trusted Research Environments. Here we describe reproducible method developed using large-scale EHRs in Wales accommodate fast efficient implementation cross-nation England as part programme. We...
Understanding and quantifying the differences in disease development different socioeconomic groups of people across lifespan is important for planning healthcare preventive services. The study aimed to measure chronic accrual, examine time individual morbidities, multimorbidity, mortality between Wales, UK.
To inform targeted public health strategies, it is crucial to understand how coexisting diseases develop over time and their associated impacts on patient outcomes health-care resources. This study aimed examine psychosis, diabetes, congestive heart failure, in a cluster of physical-mental multimorbidity, coexist time, assess the effects different temporal sequences these life expectancy Wales.
Abstract Background Measurement of multimorbidity in research is variable, including the choice data source used to ascertain conditions. We compared estimated prevalence and associations with mortality using different sources. Methods A cross-sectional study SAIL Databank 2,340,027 individuals all ages living Wales on 01 January 2019. Comparison constituent 47 conditions from primary care (PC), hospital inpatient (HI), linked PC-HI sources examination between condition count 12-month...
Objective This study aims to create a national ethnicity spine based on all available records in linkable anonymised electronic health record and administrative data sources. Design A longitudinal using individual-level population-scale from 26 sources within the Secure Anonymised Information Linkage Databank. Setting The is created for population of Wales-UK over 22 years (between 2000 2021). Procedure participants total 46 million 4 297 694 individuals have been extracted, harmonised,...
Introduction Multimorbidity is widely recognised as the presence of two or more concurrent long-term conditions, yet remains a poorly understood global issue despite increasing in prevalence. We have created Wales e-Cohort (WMC) to provide an accessible research ready data asset further understanding multimorbidity. Our objectives are create platform support which would help understand prevalence, trajectories and determinants multimorbidity, characterise clusters that lead highest burden on...
IntroductionCOVID-19 risk prediction algorithms can be used to identify at-risk individuals from short-term serious adverse COVID-19 outcomes such as hospitalisation and death. It is important validate these in different diverse populations help guide management decisions target vaccination treatment programs the most vulnerable society. ObjectivesTo externally QCOVID algorithm that predicts mortality adult population of Wales, UK. MethodsWe conducted a retrospective cohort study using...
Abstract There is a need for better understanding of the risk thrombocytopenic, haemorrhagic, thromboembolic disorders following first, second and booster vaccination doses testing positive SARS-CoV-2. Self-controlled cases series analysis 2.1 million linked patient records in Wales between 7th December 2020 31st 2021. Outcomes were first diagnosis haemorrhagic events primary or secondary care datasets, exposure was defined as 0–28 days post-vaccination reverse transcription polymerase chain...
The novel coronavirus SARS-CoV-2, which emerged in December 2019, has caused millions of deaths and severe illness worldwide. Numerous vaccines are currently under development a few have now been authorised for population-level administration by several countries. As 20 September 2021, over 48 million people received their first vaccine dose 44 second across the UK. We aim to assess uptake rates, effectiveness, safety all approved COVID-19 UK.We will use prospective cohort study designs...
From September 2021, Health Care Workers (HCWs) in Wales began receiving a COVID-19 booster vaccination. This is the first dose beyond primary vaccination schedule. Given emergence of new variants, vaccine waning vaccine, and increasing hesitancy, there need to understand uptake subsequent breakthrough this high-risk population.
Injury surveillance has been established since the 1990s, but is still largely based upon single-source data from sentinel sites. The growth of electronic health records and developments in privacy protecting linkage technologies provide an opportunity for more sophisticated systems.
Nationally, opioid overdose remains strikingly persistent among people experiencing homelessness and housing instability. Limited information is available about the characteristics of this phenomenon in economically disadvantaged communities color. This study sought to evaluate association between key contextual factors a non-fatal who use heroin Washington Heights, New York City. We conducted cross-sectional survey (N = 101) participants seeking harm reduction services reported last three...
Vaccination programs against COVID-19 vary globally with estimates of vaccine effectiveness (VE) affected by type, schedule, strain, outcome, and recipient characteristics. This study assessed VE BNT162b2 ChAdOx1 vaccines PCR positive SARS-CoV-2 infection, hospital admission, death among adults aged 50 years older in Wales, UK during the period 7 December 2020 to 18 July 2021, when Alpha, followed Delta, were predominant variants. We used individual-level linked routinely collected data...
There is some evidence that exam results are worse when students acutely exposed to air pollution. Studies investigating the association between pollution and academic attainment have been constrained by small sample sizes.Cross sectional educational data (2009-2015) from aged 15-16 years in Cardiff, Wales were linked primary health care data, modelled measured pollen analysed using multilevel linear regression models. Annual cohort, school individual level confounders adjusted for single...
Summary The Emergency Medical Retrieval and Transfer Service for Wales launched in 2015. This service delivers senior pre‐hospital doctors advanced critical care practitioners to the scene of time‐critical life‐ limb‐threatening incidents provide decision‐making clinical care. impact on 30‐day mortality was evaluated retrospectively using a data linkage system. study included patients who sustained moderate‐to‐severe blunt traumatic injuries (injury severity score ≥ 9) between 27 April 2015...
While injuries can impact on children's educational achievements (with threats to their development and employment prospects), these risks are poorly quantified. This population-based longitudinal study investigated the of an injury-related hospital admission Welsh academic performance.
Injury is a leading contributor to the global disease burden in children and places at risk for adverse lasting impacts on their health-related quality of life (HRQoL) development. This study aimed identify key predictors HRQoL following injury childhood adolescence.Data from 2259 survivors (<18 years when injured) were pooled four longitudinal cohort studies (Australia, Canada, UK, USA) paediatric Validating Burden Estimates Study (VIBES-Junior). Outcomes Paediatric Quality Life Inventory...